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HIV study leads to insights into deadly infection
Date:7/8/2014

Research led by the University of Adelaide has provided new insights into how the HIV virus greatly boosts its chances of spreading infection, and why HIV is so hard to combat.

HIV infects human immune cells by turning the infection-fighting proteins of these cells into a "backdoor key" that lets the virus in. Recent research has found that another protein is involved as well. A peptide in semen that sticks together and forms structures known as "amyloid fibrils" enhances the virus's infection rate by up to an astonishing 10,000 times.

How and why these fibrils enhance infection and cause toxicity in the body's cells remains unknown.

The HIV fibrils known as "semen-derived enhancers of viral infection" (SEVI) have been studied by chemistry and pharmacology researchers at the University of Adelaide. The results of this work have now been published online in the journal Biochimica et Biophysica Acta.

"Amyloid fibrils play an important role in a number of prominent diseases, such as Parkinson's, Alzheimer's and others, and it's absolutely essential that we understand how they work if we have any hope of developing new drugs to stop them," says lead author Dr Ian Musgrave, from the University's School of Medical Sciences.

In laboratory studies, the team found that the HIV fibrils are toxic towards cells from the nervous system. They also found that even when the fibril is broken apart, its constituent elements continue to be toxi
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Contact: Dr. Ian Musgrave
ian.musgrave@adelaide.edu.au
61-883-133-905
University of Adelaide
Source:Eurekalert

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