Navigation Links
HIV study identifies key cellular defence mechanism
Date:11/7/2011

Scientists have moved a step closer to understanding how one of our body's own proteins helps stop the human immunodeficiency virus (HIV-1) in its tracks.

The study, carried out by researchers at the University of Manchester and the Medical Research Council's National Institute for Medical Research and published in Nature, provides a blueprint for the design of new drugs to treat HIV infection, say the researchers.

Scientists in the United States and France recently discovered that a protein named SAMHD1 was able to prevent HIV replicating in a group of white blood cells called myeloid cells.

Now, crucially, the teams from Manchester and the MRC have shown how SAMHD1 prevents the virus from replicating itself within these cells, opening up the possibility of creating drugs that imitate this biological process to prevent HIV replicating in the sentinel cells of the immune system.

"HIV is one of the most common chronic infectious diseases on the planet, so understanding its biology is critical to the development of novel antiviral compounds," said Dr Michelle Webb, who led the study in Manchester's School of Biomedicine.

"SAMHD1 has been shown to prevent the HIV virus replicating in certain cells but precisely how it does this wasn't known. Our research has found that SAMHD1 is able to degrade deoxynucleotides, which are the building blocks required for replication of the virus.

"If we can stop the virus from replicating within these cells we can prevent it from spreading to other cells and halt the progress of the infection."

Co-author Dr Ian Taylor, from the MRC's National Institute for Medical Research, added: "We now wish to define more precisely, at a molecular level, how SAMHD1 functions. This will pave the way for new therapeutic approaches to HIV-1 and even vaccine development."


'/>"/>
Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-077-178-81563
University of Manchester
Source:Eurekalert

Page: 1

Related biology news :

1. UI researcher to study glaucoma in dogs
2. New study suggests EU biofuels are as carbon intensive as petrol
3. BGSU researchers harness power of genome institute for Great Lakes study
4. Albert Einstein College of Medicine receives $8 million from NIH to study how cancer spreads
5. Vegetarian diet, physical activity protect against diabetes in black population, study shows
6. Reprogramming stem cells to a more basic form results in more effective transplant, study shows
7. Study shows new medication effectively treats underlying cause of cystic fibrosis
8. Study: Crop diversity myths persist in media
9. New study reveals coral reefs may support much more biodiversity than previously thought
10. Animal study suggests that newborn period may be crucial time to prevent later diabetes
11. Drying intensifying wildfires, carbon release ninefold, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... a newly discovered hadrosaur with a truly ... Rhinorex condrupus by paleontologists from North Carolina ... what is now Utah approximately 75 million years ... which translates roughly into "King Nose," was a ... hadrosaurs like Parasaurolophus and Edmontosaurus. Hadrosaurs are usually ...
(Date:9/19/2014)... A new resource unveiled today by researchers from ... College Dublin provides both experienced and aspiring researchers ... build, and operate robots made from soft, flexible ... printing, laser cutters, and other advances in manufacturing ... important field. Using principles drawn from conventional rigid ...
(Date:9/19/2014)... of Oklahoma biology professor will study the unique bioelectric ... could eventually benefit people,s health. The OU researcher ... energy required to produce the signals used to map ... signals at a rate of 500-600 discharges a second ... the electric fish are extreme, but necessary for survival. ...
Breaking Biology News(10 mins):New hadrosaur noses into spotlight 2Soft robotics 'toolkit' features everything a robot-maker needs 2
... Microbial fuel cells, chemical sensors for your iPhone, and ... batteries, safer nuclear power, and new crime scene investigation ... the science of materials, interfaces, and processing. Detailed press ... 60th International Symposium & Exhibition will take place Oct. ...
... The harmful effects of increasingly popular designer cannabis products ... but now a group of researchers is reporting progress ... published in the ACS journal Analytical Chemistry , ... physicians diagnose and treat the thousands of young adults ...
... This news release is available in French . ... Montreal and the Institut universitaire de gratrie de Montral examined ... without mild cognitive impairment (MCI) at the early stages of ... more cortical thinning and subcortical atrophy over time compared with ...
Cached Biology News:AVS science symposium in Long Beach Oct. 27 -- Nov. 2 2
(Date:9/18/2014)... Lewisville, TX (PRWEB) September 18, 2014 ... PVC-C, a FM-4910 listed material, to stay competitive ... industries. These high-performance materials ultimately impact product ... company’s President and owner. , Established in 1980 ... held strong as many fabricators have left the ...
(Date:9/18/2014)... DIEGO , Sept. 18, 2014  MEI Pharma, Inc. ... the clinical development of novel therapies for cancer, announced today ... Executive Officer, will present at BioCentury,s NewsMakers in the ... 8:30 a.m. Eastern time from the Millennium Broadway Hotel & ... live webcast of the presentation can be accessed at ...
(Date:9/18/2014)... SEATTLE , Sept. 18, 2014 /PRNewswire/ - Oncothyreon ... pricing of previously announced concurrent but separate underwritten offerings ... price to the public of $2.00 per share, for ... of its Series A Convertible Preferred Stock at a ... expected gross proceeds of $20 million. Each share of ...
(Date:9/18/2014)... Sept. 18, 2014   Sigma-Aldrich Corporation ... has entered into a new gene editing partnership ... Vector Core. Under the partnership, Sigma-Aldrich will provide ... design consultation, and dedicated gene editing bioinformaticians. ... editing-based research at the U-M Medical School. One ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4
... Fla. -- Engineers at Florida State Universitys National High Magnetic ... that could literally shed new light on nanoscience and semiconductor ... Helix -- is operational in 2010, researchers will have the ... not only down the bore, or center, of the magnet, ...
... N.J., Oct. 31 Amicus Therapeutics,(Nasdaq: ... molecule,orally-active pharmacological chaperones for the treatment of ... the third quarter of 2007.,On a reported ... Accepted,Accounting Principles (GAAP), Amicus announced a net ...
... Calif., Oct. 31 Align,Technology, Inc. (Nasdaq: ... of straightening teeth without wires or brackets, has ... for Silicon Valley, a,ranking of the fastest growing ... region by Deloitte & Touche USA LLP, one ...
Cached Biology Technology:Let there be light: new magnet design continues magnet lab's tradition of innovation 2Amicus Therapeutics Announces Third Quarter 2007 Financial Results 2Amicus Therapeutics Announces Third Quarter 2007 Financial Results 3Amicus Therapeutics Announces Third Quarter 2007 Financial Results 4Amicus Therapeutics Announces Third Quarter 2007 Financial Results 5Amicus Therapeutics Announces Third Quarter 2007 Financial Results 6Amicus Therapeutics Announces Third Quarter 2007 Financial Results 7Amicus Therapeutics Announces Third Quarter 2007 Financial Results 8Align Technology, Inc. Ranked 23rd in Deloitte's Technology Fast 50 Program for Silicon Valley Scientific & Medical Equipment, and Bio-Technology Companies 2Align Technology, Inc. Ranked 23rd in Deloitte's Technology Fast 50 Program for Silicon Valley Scientific & Medical Equipment, and Bio-Technology Companies 3
... 8-iso PGE2 is one of several isoprostanes ... is a potent renal vasoconstrictor in the rat. ... with IC50 values of 0.5 and 5 µM, ... the rat at a concentration of 4 mg/kg/min, ...
... The Centra-CL5R multi-purpose centrifuge offers ... a large assortment of rotor options, ... of laboratory applications., Maximum Versatility , ... 21,000 xg) angle rotors or high-volume (4 ...
...
... The Turn & Cast submarine gel systems used gasketed ... the gel in the tank. Turn it back and ... For added convenience, each Turn & Cast tray is ... near the edge of the tray and one in ...
Biology Products: