Navigation Links
HIV protein unveils vaccine target
Date:3/31/2011

An international study headed by a UC Davis scientist describes how a component of a potential HIV vaccine opens like a flower, undergoing one of the most dramatic protein rearrangements yet observed in nature. The finding could reveal new targets for vaccines to prevent HIV infection and AIDS. A paper describing the work was published online this week in the journal Proceedings of the National Academy of Sciences.

In the new study, researchers from the U.S., Sweden and France explored the structure and behavior of the HIV envelope protein complex, which could potentially serve as a component of a vaccine aimed at eliciting the human immune system to generate antibodies against HIV.

"By opening up these less exposed regions, we might be able to raise more broadly cross-reactive antibodies to HIV," said R. Holland Cheng, professor of molecular and cellular biology at UC Davis and senior author of the study.

HIV infects a type of white blood cell called the CD4 T cell, weakening the immune system and leading to AIDS. HIV attaches to these cells through the envelope protein complex, which is made up of three gp120 proteins and three gp41 proteins, Cheng said.

First, the gp120 protein attaches to a CD4 protein on the victim cell's membrane. Then it uses gp41 to punch a hole through the membrane.

UC Davis graduate student Carlos Moscoso and project scientist Li Xing, working in Cheng's laboratory, used a cryoelectron microscope to study the structure of the complex and how it changes when it is exposed to a piece of the CD4 protein. A cryoelectron microscope derives three-dimensional images of complex protein structures from samples frozen in liquid nitrogen.

They found that when the HIV protein complex attaches to a CD4 protein, it rotates and flattens, exposing more of the gp41 proteins in the middle probably allowing the gp41 protein to get closer to the cell membrane so it can lock on.

It a
'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
HIV protein unveils vaccine target
(Date:5/7/2015)... 2015 Fingerprint Cards (FPC) ... FPC1035, FPC,s smallest touch fingerprint sensors to date.  ... for integration on the backside of the phone, ... possibilities to integrate touch fingerprint sensors in the ... possibilities for module manufacturers to customize the look ...
(Date:4/27/2015)... 2015  For more than four decades, AUVSI,s ... the premier worldwide event for the unmanned land, sea, ... event for any local, national, or trade news organization ... markets and current applications of unmanned technologies. The conference ... $48 billion industry, and how it will soon impact ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... Dr. Ron Koder, assistant professor of physics at The City ... devised a novel method for producing an artificial protein capable ... recently awarded a three-year $1.3 million grant from the U.S. ... be administered to injured troops on the battlefield. "Engineered ...
... & Biotechnology News (GEN) recently co-sponsored a roundtable discussion ... in environment clean-up after manmade or natural disasters. "Gulf ... Impact and to Help in Remediation" was also sponsored ... of Massachusetts Boston, where the discussions took place. Part ...
... on hold until after 40, or even 45, will be ... there are associated risks for babies when postponing child-bearing, the ... Aviv University,s Sackler School of Medicine and the Hospital for ... in Israel, a country that supports in vitro fertilization (IVF) ...
Cached Biology News:CCNY professor gets grant to develop 'artificial blood' 2Rocking the cradle after 45 2
(Date:5/28/2015)...  Quest Diagnostics Incorporated (NYSE: DGX ), the ... it is scheduled to speak at the Jefferies 2015 ... , the company,s President and CEO, will discuss the ... is scheduled for Tuesday, June 2, 2015 at 8:00 ... webcast live during the conference and will be available ...
(Date:5/28/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/3nl6s2/neuroprotection ) has announced ... "Neuroprotection - Drugs, Markets and Companies" to ... role of neuroprotection in acute disorders such as ... well as in chronic diseases such as neurodegenerative ... damage to neural tissues are similar in all ...
(Date:5/28/2015)... 2015 BioNorth Texas (BioNorthTX), an ... the life sciences industry in northern region of ... at The Foundry in Dallas on April 27, ... together a broad spectrum of biotech professionals from ... early successes in partnering with key life sciences ...
(Date:5/28/2015)... and London (PRWEB) May 28, 2015 ... of Computer Aided Engineering software, announced today it ... Inc. (PSRI). CD-adapco will provide state-of-the-art engineering simulation ... will share their expertise and experiences in analyzing ... refining industry members and advance the understanding of ...
Breaking Biology Technology:Quest Diagnostics to Speak at the Jefferies 2015 Global Healthcare Conference 2Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 2Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 3BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2
... Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 -- AMSTERDAM, The Netherlands, August 31, 2010 ... ... --> ... function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
... 21st Century Biochemicals, Inc . of Marlborough, ... ranking of the 5,000 fastest-growing private companies in the country ... Century Biochemicals was ranked #2626 after being ranked #575 in ... comprehensive look at the most important segment of the economy ...
... NEW YORK, Aug. 30 Rx Communications Group, LLC today ... will preside over the Closing Bell ceremony on Wednesday, September ... to commemorate the firm,s tenth year anniversary of providing award-winning ... A live webcast of the Closing Bell ceremony will ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 2Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 3Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 4Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 5Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 6Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 7Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 8Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 9Amsterdam Molecular Therapeutics Reports Half-Year Results 2010 1021st Century Biochemicals Marks Its Third Consecutive Year on the Inc. 5000 2Rx Communications Group to Ring NASDAQ Closing Bell 2
Vented Caps for 75 cm2 Flasks...
BD BioCoat Poly-D-Lysine 60 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of poly-D-lysine....
BD BioCoat Laminin 60 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
... Series 4000 incorporates the critical design features ... in biomarker research. The Series 4000 delivers ... converting biomarker discoveries to biomarker assays all ... is designed to fit into the research ...
Biology Products: