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HIV makes protein that may help virus's resurgence
Date:2/25/2011

uses control their infectivity," said Finkel.

The researchers carried out their work in HeLa cells, a human cell line long used in cell studies, as well as in human T cells, immune cells found in the blood. They identified two proteins, Brd4 and Cdk9, which interact with Vif. This interaction was a new discovery, although the proteins were already known to regulate the progression of the cell cycle.

Identifying Vif's cellular partners may also implicate them as potential targets for therapy. "If we can interrupt the activity of Brd4 or Cdk9, we may be able to prevent latent infection from becoming active," said Finkel. "Alternatively, by harnessing Brd4 or Cdk9, we may be able to drive cells out of latency and make the virus susceptible to anti-HIV drugs." She added that early preclinical testing of inhibitors is getting under way for other conditions, but cautioned that it is too early to foresee whether, or how soon, her research findings will lead to clinical treatments for HIV.


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Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

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