Navigation Links
HIV makes protein that may help virus's resurgence
Date:2/25/2011

New research enhances the current knowledge of how human immunodeficiency virus type-1 (HIV-1), which causes AIDS, controls the cell cycle of cells that it infects. The new findings may shed light on how the virus reactivates after entering a dormant state, called latency.

"As we better understand the biological events that revive HIV from latency, we hope to devise ways to eventually intervene in this process with better treatments for people with HIV infection," said study leader Terri H. Finkel, M.D., Ph.D., chief of Rheumatology at The Children's Hospital of Philadelphia.

Finkel is the senior author of a study published in the Jan. 27 issue of the journal Blood. The first author, also from Children's Hospital, is Jiangfang Wang, M.D., Ph.D.

Viral latency is one of the persistent problems in treating HIV infection. Current combinations of anti-HIV drugs can reduce HIV to undetectable levels, but the virus hides in latently infected cells in a sort of hibernation. If a patient stops taking medication, or is weakened by a different infection, HIV can make a resurgence out of its viral reservoirs, often becoming resistant to previously effective drugs.

The current study focused on a protein, Vif (for viral infectivity factor), that HIV-1 produces. Finkel and colleagues previously discovered that Vif causes HIV-infected cells to stop growing at one phase of the cell cycle, the G2 phase. The study team has now found that Vif also acts at an earlier stage in the cell cycle, driving cells out of the G1 phase and into the more active S phase.

This activity may be important, said Finkel, because G1 is a resting phase, and a biological interaction that "wakes up" a latent infected cell may reactivate the infection. Other viruses that have a latent infectious state, such as the herpes virus and the Epstein-Barr virus, also express proteins that drive a transition from G1 to S phase. "By regulating the cell cycle, vir
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Trustee makes donation to start new solar energy research center at Rensselaer
2. What makes an axon an axon?
3. Feed a cold, feed a fever: Research shows calorie cut makes it harder to fight flu
4. Fly guy makes memory breakthrough
5. Our unconscious brain makes the best decisions possible
6. Biophysical Reviews makes debut in 2009
7. Tree lizard’s quick release escape system makes jumpers turn somersaults
8. Rett Syndrome Research Trust advisor makes significant discovery
9. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
10. Mount Sinai Hospital researcher makes stem cell breakthrough
11. Red wine vs. white? It makes no difference when it comes to breast-cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... invisible is probably the ultimate form of camouflage: you ... And this strategy is not as uncommon as you ... Baltimore County, USA, explains that the larval life stages ... one part of the anatomy that most creatures cannot ... eyes have to shield each individual eye unit with ...
(Date:9/18/2014)... the protective tentacles of host anemones, but new research ... kilometres across the open ocean. Although the process of ... is the first time that the high level exchange ... Dr Steve Simpson, Senior Lecturer in Marine Biology and ... from the Australian Research Council Centre of Excellence for ...
(Date:9/17/2014)... UCLA atmospheric scientists were instrumental in the creation of ... tool to classify the fire threat potential of the ... a spark into an inferno. The index was introduced ... with UCLA and San Diego Gas and Electric. , ... to "extreme" that will be used to help fire ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... suggest that patients with aggressive non-Hodgkin,s lymphoma in the ... researchers say. At the ESMO Conference Lugano (ECLU) ... group headed by Prof. Hamdy Azim from Cairo University ... rather than every 3 weeks as usual, improved treatment ...
... Since earliest recorded history, and presumably beyond, humans have ... of winged creatures around them, and unfailingly ended in ... particularly similar to nature,s fliers, and today there is ... chopper and the humble bumblebee, despite similar flight patterns. ...
... your imagination run away with you may actually influence ... University has found that mental imagery--what we see with ... The research was published online June 26 by the ... imagery leads to a short-term memory trace that can ...
Cached Biology News:New treatment approach promising for lymphoma patients in the developing world 2Want to fly? Don't copy the birds and the bees 2'Mind's eye' influences visual perception 2'Mind's eye' influences visual perception 3
(Date:9/19/2014)... NYU Langone Medical Center have found a way to ... turning adult cells into so-called pluripotent stem cells by ... new technique in mice, the researchers increased the number ... more than 20-fold compared with the standard method. They ... should generally accelerate research aimed at using stem cells ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
(Date:9/19/2014)... , September 19, 2014 ... and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition ... Chromatography Columns"  report to their offering.  ... market is one of the fastest-growing segments in ... $1.2 billion in 2013, and expected to reach ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Micro Market Monitor : Global Pre-packed Chromatography Columns 2POCT Market in China 2014-2018 2
... EUGENE, Ore. -- A collaborative Oregon State University-University of ... National Science Foundation grant in 2008, is moving into ... grant. The new NSF funding, awarded through its ... for Sustainable Materials Chemistry to expand research and development ...
... Medical Center in Tucson (UMC) is validating the VENTANA INFORM ... on the BenchMark XT automated slide staining instrument to help ... effort to change the paradigm for targeted treatment therapies. The ... of the Roche group, is the first fully automated assay ...
... For years, dieters and researchers around the world have ... (human Chorionic Gonadotropin) supplements can have on the battle against ... by Creative Bioscience, a leader in diet support products ... take advantage of the powerful metabolic boost of hCG without ...
Cached Biology Technology:Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 2Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 3Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 4Early Adopter of INFORM HER2 Dual ISH Assay Optimistic About Impact on Patient Care, Hospital Bottom Line 2Early Adopter of INFORM HER2 Dual ISH Assay Optimistic About Impact on Patient Care, Hospital Bottom Line 3Early Adopter of INFORM HER2 Dual ISH Assay Optimistic About Impact on Patient Care, Hospital Bottom Line 4Hormone-free hCG Zero Capsules™ Boost Metabolism to Enhance Weight Loss Without Starvation 2Hormone-free hCG Zero Capsules™ Boost Metabolism to Enhance Weight Loss Without Starvation 3Hormone-free hCG Zero Capsules™ Boost Metabolism to Enhance Weight Loss Without Starvation 4
... Analyzer for General Chemistries, Specialty Chemistries, QC, Reagent Development, Pharmaceutical Development, Physician Owned Labs, Drugs ... user-selectable wavelengths. ... ... ...
Recorder REC-111 single-channel, 1. Category: Chromatography Systems & Accessories, Systems....
2,4,6, Trinitrophenyl hapten is conjugated to lipopolysaccharide (LPS)....
For the quantitative determination of cyclic AMP (cAMP) concentrations in cell culture supernates, serum, plasma, saliva, urine and cell lysates....
Biology Products: