Navigation Links
HIV isolate from Kenya provides clues for vaccine design
Date:1/2/2008

Two simple changes in its outer envelope protein could render the AIDS virus vulnerable to attack by the immune system, according to research from Kenya and the Fred Hutchinson Cancer Research Center published in PLoS Medicine.

The results could provide important clues for designing an effective AIDS vaccine, which is badly needed to decrease the number of new HIV infections, now estimated at about 2.5 million per year worldwide.

Although most people infected with HIV produce antibodies against the virus within several weeks following infection, these antibodies rarely prevent the infection from progressing to symptomatic AIDS.

While studying a group of women at risk of HIV in Mombasa, Julie Overbaugh and colleagues noticed that one woman carried an AIDS virus that was easily inactivated by antibodies. They initially described this case in 2007 in the Journal AIDS.

Analyzing this womans virus, they found that it contains mutations in four amino acids in the envelope protein, two of which, when introduced into unrelated strains of HIV in the laboratory, conferred sensitivity to inactivation by a number of antibodies produced in people infected with HIV.

The researchers propose that these mutations cause a change in the overall structure of the envelope protein that results in exposure to the immune system of regions that are normally hidden. If further research confirms this idea, vaccines containing envelope proteins that include these mutations might be able to stimulate an antibody response that would protect against infection with HIV.


'/>"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists decode genomes of diverse TB isolates
2. Improved e-jet printing provides higher resolution and more versatility
3. Canada provides $1.4M for removal of hazardous trees from provincial recreation sites
4. Study involving more than 100 scientists provides new insights on green algae
5. Shell Provides Consumers Gasoline Industrys First Pay By Touch Technology at the Pump
6. Book on little-known species and conservation provides guidance to managers and others
7. Study begins to reveal clues to the cause and progression of sepsis
8. Chlamy genome holds clues for renewable energy, the environment and human health
9. How schizophrenia develops: Major clues discovered
10. Tiny fish can yield big clues to Delaware River health
11. Fossils excavated from Bahamian blue hole may give clues of early life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... 2016 http://www.apimages.com ) - --> ... available at AP Images ( http://www.apimages.com ) - ... to produce the new refugee identity cards. DERMALOG will be unveiling ... in Hanover next week.   --> ... used to produce the new refugee identity cards. DERMALOG will be ...
(Date:3/9/2016)... -- This BCC Research report provides an overview of ... (RNA Seq) market for the years 2015, 2016 and ... data analysis, and services. Use this report ... such as RNA-Sequencing tools and reagents, RNA-Sequencing data analysis, ... segment and forecast their market growth, future trends and ...
(Date:3/3/2016)... -- FlexTech, a SEMI Strategic Association Partner, awarded five FLEXI ... Leadership in Education, and, in a category new this ... year of the FLEXI Awards and the winners join ... past years . Judging was done on a set ... by a panel of non-affiliated, independent, industry experts. ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... 2016 The report "Biochips ... Gene Expression) Lab-on-a-chip (IVD & POC, Proteomics), ... Centers), Fabrication Technology (Microarrays, Microfluidics) - Forecast ... is expected to reach USD 17.75 Billion ... 2015, growing at a CAGR of 18.4% ...
(Date:5/3/2016)... ... May 03, 2016 , ... Flagship Biosciences, the ... Gillett to its Board of Directors. Dr. Gillett recently retired from Charles River ... President and Chief Scientific Officer. A board-certified veterinary pathologist, Dr. Gillett joined Charles ...
(Date:5/3/2016)... Texas , May 3, 2016  Dr. ... plastic surgeon in The Woodlands, Texas ... destroys 24 percent of treated fat cells in just ... woman. Close to 90 percent of Americans report feeling ... options. Nonsurgical fat reduction procedures are a growing industry. ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... its clients in mind, the fresh look and added functionality give the agricultural ... years have seen a dynamic shift in agriculture – from precision farming via ...
Breaking Biology Technology: