Navigation Links
HIV is a 'double hit' to the brain
Date:8/15/2007

could be triggered by gp120the viral coat protein that latches onto human cellseven in the absence of any viral infection. They also showed that the protein disrupts a key cell-cycle pathway (including p38 mitogen-activated protein kinase or MAPK), leading to the death of certain mature neurons.

The researchers now find that gp120 in mice also slows the production of new neurons in the hippocampus, a brain region central to learning and memory. Newborn neurons become integrated into existing brain circuits and are thought to contribute to certain forms of learning and memory, they said.

Moreover, they found that it is the same MAPK pathway earlier linked to the death of mature neurons that lies at the root of the progenitor cells dysfunction. That a similar enzyme is involved in both brain-damaging effects is simply serendipitous, according to the researchers.

Knowing the mechanism, we can start to approach this therapeutically, Lipton said. This indicates that we might eventually treat this form of dementia by either ramping up brain repair or protecting the repair mechanism, Kaul added.


'/>"/>
Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
3. Double triumph in stem cell quest
4. Specialized immune-system B cells play double-barreled role
5. Double trouble: Cells with duplicate genomes can trigger tumors
6. Plants have a double line of defence
7. Environmental lessons from tsunami as worlds coastal population doubles
8. California computer scientists double volume of data in NIH biotech repository
9. Logging doubles threat to the Amazon, rivaling clear-cutting, study suggests
10. Oil spills and climate change double the mortality rate of British seabirds
11. Sleep deprivation doubles risks of obesity in both children and adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... landmark study aimed at improving the food intake, health ... care homes is among three projects at the University ... from the Canadian Institutes of Health Research (CIHR). ... Health Sciences at Waterloo, and a Schlegel research chair ... years to investigate why many Canadians living in long-term ...
(Date:8/21/2014)... WHEN: , Saturday to Wednesday, Oct. 18-22, 2014 ... 111 W. Harbor Drive, San Diego, CA 92101 ... sessions and other presentations of the latest research ... Opening plenary session featuring high-scoring abstracts on rare ... of various cancers, and treatment for sun sensitivity ...
(Date:8/21/2014)... developed a novel and versatile modeling strategy to simulate ... materials as well as for studying polyelectrolytes, including DNA ... model much larger and more complex polyelectrolyte systems, and ... lead author of a paper on the work and ... Science and Engineering. "This is a big step forward ...
Breaking Biology News(10 mins):Grants will fund landmark aging research at Waterloo 2American Society of Human Genetics 2014 Annual Meeting 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... announced today its plans to launch a new cancer ... women with advanced stage ovarian cancer. This innovative treatment ... and developed by AVAX Technologies, Inc. (OTCMarket: AVXT.OB). ... is to help our patients win the battle against ...
... The new in-vitro technique pioneered by Dr Amanda Hayes ... directly exposes human cells to airborne toxicants and measures ... polyester membrane inside a small diffusion chamber and then ... as one hour's exposure, they can study cell growth ...
... some women seem to be more ill-tempered than others? ... as anger, hostility and aggression may be genetic, rooted ... Ph.D., of the Cardiovascular Behavioral Medicine Program at the ... the American Psychosomatic Society's Annual Meeting, held in Budapest, ...
Cached Biology News:Soft-cell approach cuts animal tests 2Soft-cell approach cuts animal tests 3
(Date:8/21/2014)... 21, 2014  Decision Resources Group finds that ... and Mexico currently ... newly approved agents, the anticipated label extension of ... launch of emerging biologics will substantially increase the ... emerging IL-5 inhibitors will introduce a new dynamic to ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Pursuit ... selling optimization technology and services for Life Sciences ... “Grading Pharma’s Use of New Commercial Sales Models” ... & Analytics. , The article examines some innovative ... that are being tested in the pharmaceutical market. ...
(Date:8/20/2014)... Aug. 20, 2014 Clintrax Global, Inc., ... in Raleigh, NC , recently ... as Vice President of Administration. ... all corporate processes, including their alignment with company ... Brad worked as an HR executive, specializing in ...
(Date:8/20/2014)... High performance computing (HPC) will be ... climate and Earth system model to address the ... Eight national laboratories, including Lawrence Livermore , ... Atmospheric Research, four academic institutions and one private-sector ... laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los Alamos, ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2Clintrax Global, Inc. Announces Addition to Executive Team 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... No Child Should Die of Diabetes, BRUSSELS, October ... it is bringing together key opinion,leaders to push for ... diabetes in developing countries without access to care., ... in the,Developing World, will be held on Saturday, October ...
... Therapeutics is,presenting new data today representing an ... to enhance outcomes in patients,suffering from lower ... "Local Catheter-Directed Elastase Therapy: A Novel,Approach to ... at the 20th,annual Transcatheter Cardiovascular Therapeutics (TCT) ...
... risk of basal,cell carcinoma, and are integrated into ... Oct. 13 Scientists at,deCODE genetics (Nasdaq: ... of two single-letter variations in the human genome ... the most common cancer among,people of European ancestry. ...
Cached Biology Technology:International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 2International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 3Proteon Therapeutics to Present New Data on PRT-201 at Transcatheter Cardiovascular Therapeutics (TCT) Annual Symposium in Washington, D.C., October 13, 2008 2deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 2deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 3deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 4
... Detection System combines the indirect labeling ... and Signets unique formulation of ultra ... reliablility. Signet reagents will achieve excellent ... automated protocols. ,Signets USA Detection reagents ...
... Each Signet Level 2 Detection System ... avidin-biotin chemical bonding principle and Signets ... provide sensitivity, specificity and reliablility. Signet ... in both manual and automated protocols. ...
XPMC2H Immunogen: XPMC2H (NP_065118, 323 a.a. ~ 423 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
6X DNA Gel Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Biology Products: