Navigation Links
HIV is a 'double hit' to the brain
Date:8/15/2007

could be triggered by gp120the viral coat protein that latches onto human cellseven in the absence of any viral infection. They also showed that the protein disrupts a key cell-cycle pathway (including p38 mitogen-activated protein kinase or MAPK), leading to the death of certain mature neurons.

The researchers now find that gp120 in mice also slows the production of new neurons in the hippocampus, a brain region central to learning and memory. Newborn neurons become integrated into existing brain circuits and are thought to contribute to certain forms of learning and memory, they said.

Moreover, they found that it is the same MAPK pathway earlier linked to the death of mature neurons that lies at the root of the progenitor cells dysfunction. That a similar enzyme is involved in both brain-damaging effects is simply serendipitous, according to the researchers.

Knowing the mechanism, we can start to approach this therapeutically, Lipton said. This indicates that we might eventually treat this form of dementia by either ramping up brain repair or protecting the repair mechanism, Kaul added.


'/>"/>
Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
3. Double triumph in stem cell quest
4. Specialized immune-system B cells play double-barreled role
5. Double trouble: Cells with duplicate genomes can trigger tumors
6. Plants have a double line of defence
7. Environmental lessons from tsunami as worlds coastal population doubles
8. California computer scientists double volume of data in NIH biotech repository
9. Logging doubles threat to the Amazon, rivaling clear-cutting, study suggests
10. Oil spills and climate change double the mortality rate of British seabirds
11. Sleep deprivation doubles risks of obesity in both children and adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... conclusive evidence that the source of a unique rhythmic ... called the "bio-duck," is the Antarctic minke whale ( ... personnel in the 1960s who thought it sounded like ... various locations in the Southern Ocean, but its source ... 2013, an international team of researchers deployed acoustic tags ...
(Date:4/23/2014)... The shale gas boom has transformed the energy ... locations, it could cause conflict among the energy ... resources, say researchers. They add that degraded water ... adequate safeguards. The feature article appears in the ... , Meagan S. Mauter and colleagues point out ...
(Date:4/23/2014)... 23 April 2013 EMBO today announced Sophie Martin ... of the 2014 EMBO Gold Medal. The award acknowledges ... the organization and development of the cell. , Martin ... understand cellular polarity, in particular the way in which ... and cell division. In the last 11 years, she ...
Breaking Biology News(10 mins):Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3How to avoid water wars between 'fracking' industry and residents 2EMBO Gold Medal 2014 awarded to Sophie Martin 2
... of Leicester in collaboration with Northamptonshire Police is ... John Bond, from Northamptonshire Police Scientific Support Unit ... of Leicester,s Forensic Research Centre developed- in collaboration ... fingerprints, even after the print itself has been ...
... June 22 The Federal Bureau of Investigation (FBI) ... a five-year, $47 million contract to continue managing the ... Service (CSS) program. The contract covers the conversion of ... electronic records for the FBI. , , ...
... Delays in cargo screening significantly extend the time of ... foolproof and rapid screening and detection systems. At the ... need for efficient access control systems in ports and ... , , New analysis from Frost & Sullivan ...
Cached Biology News:New advance in revolutionary 'bullet fingerprinting' technique 2Federal Bureau of Investigation Awards Lockheed Martin Biometric Card Scanning Service Contract 2Growing Demand for Rapid Screening and Detection Systems Pushes the European Maritime Security Market, Finds Frost & Sullivan 2Growing Demand for Rapid Screening and Detection Systems Pushes the European Maritime Security Market, Finds Frost & Sullivan 3
(Date:1/15/2014)... is the device," Nobel laureate Herbert Kroemer famously ... found at the junctures where layers of different ... the interfaces between layers of metal oxides are ... favorites as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal Products ... by Buffalo BioBlower Technologies LLC ("B3") as the critical ... 2 award from the Army Corps of Engineers.  B3 ... kills all biological contaminants and destroys VOCs and other ...
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... IPSWICH, England , January 15, 2014 ... to win races on the Formula 1 track could help ... between McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based ... funded by healthcare provider Simplyhealth. Telemetry technology, which ...
Breaking Biology Technology:A deeper look at interfaces 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... subsidiary of Milwaukee-based Merge Healthcare, said it will ... surgeons . , ,The company's OrthoWorks product will ... communications system (PACS), helping support joint arthroplasty, spine, ... the firm said. , ,Mayo Clinic has 70 ...
... Installation work on Milwaukee's Wi-Fi network could begin in ... and Midwest Fiber Networks said Thursday. , ,The ... which last month selected Midwest Fiber to build and maintain ... is dry on the agreements, "equipment will be mounted on ...
... Europe, I can't help making the obvious comparisons between ... countries. , ,I've written before about Wi-Fi. In the ... about anywhere, and there is relative good will about ... Wi-Fi is not public and not inexpensive. I'm sending ...
Cached Biology Technology:U.S. risks third-world status in key technology 2U.S. risks third-world status in key technology 3
... overlays are commonly used in ... "DNA grade" agaroses either contain ... insect cells or lack the ... good overlays. Novagen's BacPlaque Agarose ...
AgarPlaque Plus Agarose 50 grams...
...
...
Biology Products: