Navigation Links
HIV is a 'double hit' to the brain
Date:8/15/2007

New evidence reported in the August issue of Cell Stem Cell, a publication of Cell Press, offers a novel perspective on how the HIV/AIDS virus leads to learning and memory deficits, a condition known as HIV-associated dementia. A protein found on the surface of the virus not only kills some mature brain cells, as earlier studies had shown, but it also prevents the birth of new brain cells by crippling adult neural progenitors, the new study finds. Those progenitor cells are the closest thing to stem cells that have been found in the adult brain.

By elucidating the mechanism responsible for the neurodegeneration and dementia seen in people infected with HIV, the findings made in mice that produce the damaging HIV protein may open the door to new therapies, according to the researchers.

The breakthrough here is that the AIDS virus prevents stem cells in the brain from dividing; it hangs them up, said Stuart Lipton of the Burnham Institute for Medical Research and the University of California at San Diego. Its the first time that the virus has ever been shown to affect stem cells.

Its a double hit to the brain, added collaborator Marcus Kaul, who is also of the Burnham Institute and UCSD. The HIV protein both causes brain injury and prevents its repair.

Physicians first recognized that HIV infection could lead to a profound form of dementiamost commonly in those with an advanced stage of the diseaseearly on. The success of antiretroviral therapies in keeping the viral load down has helped to reduce the severity of the dementia in recent years. Nonetheless, the prevalence is rising as HIV-infected people are living longer. The anti-HIV drugs dont infiltrate the brain well, allowing for a secret reservoir of virus, Lipton explained. Such persistent exposure of the central nervous system to HIV is a major risk factor for the development of HIV-associated dementia.

Liptons team previously discovered that the brain deficits
'/>"/>

Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
3. Double triumph in stem cell quest
4. Specialized immune-system B cells play double-barreled role
5. Double trouble: Cells with duplicate genomes can trigger tumors
6. Plants have a double line of defence
7. Environmental lessons from tsunami as worlds coastal population doubles
8. California computer scientists double volume of data in NIH biotech repository
9. Logging doubles threat to the Amazon, rivaling clear-cutting, study suggests
10. Oil spills and climate change double the mortality rate of British seabirds
11. Sleep deprivation doubles risks of obesity in both children and adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal ... that pinpoints fine-scale differences in genetic ancestry of individuals ... Since immigrants first arrived more than four ... has served as a meeting place for peoples ... and the ongoing mixing of peoples with African, European, ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and ... the addition of the "Samsung Galaxy S5 ... report to their offering. ... a totally different sensing technology than the iPhone ... fingerprint sensor in its product. The ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014 /PRNewswire-USNewswire/ ... a Good Clinical Practices (GCP) audit to confirm ... Administration (FDA) regulations. This accomplishment enables HITLAB to ... trials utilizing the highest principles for patient safety ... to improve global healthcare access, quality, and delivery ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... Five years ago, Professor Mirko Gojic, a researcher at the ... of researchers could do to lower the price of ,smart ... original cold-forged shape, returning the pre-deformed shape by heating ... industries. The idea was there, but problems quickly aroused from ...
... design of vaccines is rapidly expanding their use, safety, and ... of OMICS sciences for global health and vaccine design is ... special issue of OMICS: A Journal of Integrative Biology ... Inc . The issue is available free online . ...
... Sept. 23, 2011 Two Arizona university graduate students ... each received $50,000 grants from the Salt River Project ... TGen,s Pathogen Genomics Division in Flagstaff, and Brooke Hjelm, ... are each the recipients of $50,000 awards from SRP,s ...
Cached Biology News:Shape memory materials ready for mass production 2Shape memory materials ready for mass production 321st century vaccines -- innovation in design and rational use 221st century vaccines -- innovation in design and rational use 3TGen graduate students receive $50,000 each from Salt River Project's support program 2
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
(Date:12/17/2014)... 16, 2014 “Never say, ‘I ... Universität Marburg’s Department of Physics, advises young women ... newly released SPIE Women in Optics 18-month ... shy to ask questions.” , In the annual ... mathematics) occupations ranging from university professor and laboratory ...
(Date:12/17/2014)... December 17, 2014 This report ... Quartz Tubing industry. For an overview analysis, the ... application, industry chain structure, industry overview, policy analysis, ... tubing industry has witnessed rapid development with ... of acquisitions. This report mentions quartz tubing upstream ...
(Date:12/17/2014)... , Dec. 16, 2014  Vermillion, Inc. (NASDAQ: ... on gynecologic disease, today announced the next step in ... premier bio-analytics solutions provider with the naming of current ... and Chief Executive Officer, while current Chairman of the ... to serve as Chairman. These changes are effective January ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... in ... 2008 -, ... the year ended December,31, 2007, and highlighted the corporate milestones achieved during ... the Company achieved the following corporate milestones:, Progress on Lead Candidate ...
... SAN DIEGO, March 13 Arena Pharmaceuticals,Inc. (Nasdaq: ARNA ... overview of the company, including its clinical development and,discovery programs, ... Annual Health Care Conference Presentation: Wednesday, ... a.m. Pacific Time) at the Boston Marriott ...
... Surgical Recoveries, FREDERICK, Md., March 13 ... Breast Recovery Kit,for the relief of edema and ... Eppley, MD, DMD, the 1 Day Breast Recovery ... active lives the day,after surgery. Using the patented ...
Cached Biology Technology:Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 2Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 3Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 4Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 5Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 6Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 7Arena Pharmaceuticals to Present at Two Upcoming Investor Conferences 2Arena Pharmaceuticals to Present at Two Upcoming Investor Conferences 3BioElectronics Launches '1 Day Breast Augmentation Recovery Kit' 2
Certified U.S. origin. Bovine Serum:, *Certified U.S. origin. Available raw, nonsterile filtered, or sterile filtered. , , *Sterility tested , , *Low Hemoglobin levels , , *Mycoplasma testing upon...
...
Full-length cDNA 5-PRIME end of clone CS0DE013YM09 of Placenta of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86TS7] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
Biology Products: