Navigation Links
HIV drugs interfere with blood sugar, lead to insulin resistance
Date:11/22/2010

The finding will help researchers better understand the role of glucose transporters in health and disease, including the epidemic of type 2 diabetes in HIV negative patients, says Hruz. He expects the results will help scientists better understand how to develop new diabetes drugs and the role of glucose transport in diseases such as heart failure.

Hruz and his team are now studying at the molecular level how the HIV drugs inhibit GLUT4.

"We'd like to figure out exactly how these drugs interact with the transporter to aid the development of better HIV drugs," he says. "We want to find problems in glucose transport that lead to diabetes in the preclinical stage of drug development."

The team already is working with a drug developer to create a new HIV drug that the virus does not develop resistance to and does not block GLUT4.


'/>"/>

Contact: Beth Miller
millerbe@wustl.edu
314-286-0119
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
2. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
3. Discovering drugs, biofuels in tropical seas
4. Academy participates in project to discover drugs, biofuels in tropical seas
5. European researchers harness unique properties of boron to develop new drugs and diagnostics
6. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
7. Moderate use averts failure of type 2 diabetes drugs in animal model
8. Montana State University researchers find gene that regulates molds resistance to drugs
9. MSU researcher studies ties between cholesterol drugs, muscle problems
10. New technique eliminates toxic drugs in islet transplant in diabetic mice
11. REGiMMUNE receives $12 million in grants to develop transplant and allergy drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... doctors have long known that people with Down syndrome ... (ALL) during childhood, they haven,t been able to explain ... investigators has uncovered a connection between the two conditions. ... journal Nature Genetics , the researchers track the ... in Down syndrome to the cellular havoc that occurs ...
(Date:4/18/2014)... world population predicted to reach 9 billion by ... that considers human-altered landscapes such as farmland, according ... habitat that supports it might be an increasingly ... three-quarters of the land surface is directly affected ... human-caused impacts such as climate change. But what ...
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological ... even global scales. But new research from Brown University ... ancient life at the time of an impact. , ... has found fragments of leaves and preserved organic compounds ... in Argentina. The material could provide a snapshot of ...
Breaking Biology News(10 mins):Dana-Farber researchers uncover link between Down syndrome and leukemia 2Dana-Farber researchers uncover link between Down syndrome and leukemia 3Stanford researchers rethink 'natural' habitat for wildlife 2Stanford researchers rethink 'natural' habitat for wildlife 3Stanford researchers rethink 'natural' habitat for wildlife 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
... Love," conducted by Syracuse University Professor Stephanie Ortigue, reveals ... same euphoric feeling as using cocaine, but also affects ... in love only takes about a fifth of a ... and an adjunct assistant professor of neurology, both in ...
... at LSU Health Sciences Center New Orleans has found that ... the hormone that regulates water retention in the body on ... for diseases like high blood pressure, congestive heart failure, and ... November 1, 2010 issue of Endocrinology . Daniel Kapusta, ...
... has created a Green Carbon Center to bring the benefits ... other energy sources together in a way that will not ... a means to recycle carbon dioxide into useful products. ... fact is humans are throwing away a potentially valuable resource ...
Cached Biology News:Falling in love 'more scientific than you think,' according to Syracuse University professor 2LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension 2Green Carbon Center takes all-inclusive view of energy 2Green Carbon Center takes all-inclusive view of energy 3
(Date:1/15/2014)... 2014 This webinar will focus on ... safety assessment in biosimilars. , Regulatory frameworks are evolving ... development, however the complex nature of biopharmaceuticals makes the ... efficacy extremely challenging. Based on the specific aspects of ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company ... under simulated embryonic conditions, today announced that they have ... Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent ... is an amendment to the existing license between Histogen ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... Corporation announced today the,release of two major upgrades ... a multilaser capability and the Beta release of ... field well beyond,conventional optical limitations. The Multilaser ... two additional lasers including a 405nm (violet) laser ...
... Nektar,Therapeutics (Nasdaq: NKTR ) today announced the appointment ... reports to Nektar President and,CEO Howard W. Robin, and ... management team. "With his strong understanding of healthcare ... team at Nektar," Robin said. "He brings,significant experience in ...
... 28% over the prior comparable period to A$44.4 ... comparable period to A$4.6 million -- Excluding ... period to A$2.5 million from A$2.0 million -- Reported NPAT ... comparable period including one-off items -- Ellex brand product ...
Cached Biology Technology:Amnis Announces the Release of Multiple Upgrades to the ImageStream(R) System 2Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer 2Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer 3Ellex FY2007 Year End Results 2Ellex FY2007 Year End Results 3
... allows the Thermo-Fast® 96 ... PCR plates to be ... PRISM® 3700 capillary sequencer. ... information on the software ...
... • Heat activated ,• ... room temperature ,• Excellent specificity allows ... and secondary structures ,• Leaves an ... chemically modified form of GeneChoice DNA Polymerase ...
... aqueous solution. Cleaves a-(1-3)- ... carbohydrates and glycoproteins. It is particularly efficient ... the pH must be neutral or above, ... Unit Definition: One unit will ...
This adapter allows the Thermo-Fast® 96 Semi-Skirted (AB-0900 and AB-0990) PCR plates to be used directly in the ABI PRISM® 3100 sequencer without the need for software changes....
Biology Products: