The finding will help researchers better understand the role of glucose transporters in health and disease, including the epidemic of type 2 diabetes in HIV negative patients, says Hruz. He expects the results will help scientists better understand how to develop new diabetes drugs and the role of glucose transport in diseases such as heart failure.
Hruz and his team are now studying at the molecular level how the HIV drugs inhibit GLUT4.
"We'd like to figure out exactly how these drugs interact with the transporter to aid the development of better HIV drugs," he says. "We want to find problems in glucose transport that lead to diabetes in the preclinical stage of drug development."
The team already is working with a drug developer to create a new HIV drug that the virus does not develop resistance to and does not block GLUT4.
|Contact: Beth Miller|
Washington University School of Medicine