Navigation Links
HIV-derived antibacterial shows promise against drug-resistant bacteria
Date:6/19/2013

A team of researchers at the University of Pittsburgh has developed antibacterial compounds, derived from the outer coating of HIV, that could be potential treatments for drug-resistant bacterial infections and appear to avoid generating resistance. These new agents are quite small, making them inexpensive and easy to manufacture. The research was published in the June 2013 issue of the journal Antimicrobial Agents and Chemotherapy.

The first of many probable applications will likely be the chronic bacterial infections in the lungs of cystic fibrosis patients "that frequently develop resistance to all standard antibiotics, and are the leading cause of death in these patients," says senior author Ronald Montelaro.

The lead compound shows powerful antibacterial activity against clinical isolates of diverse pathogenic bacteria that are resistant to most antibiotics. These agents, called engineered cationic antimicrobial peptides (eCAPs) "may be applicable to treatment of other respiratory infections, topical infections, and systemic infections," says Montelaro.

The genesis of the new agent was basic research on HIV envelope protein structure and function, says Montelaro. As part of this research, "we identified highly conserved unique protein sequences that were predicted by computer modeling to assume structures characteristic of natural antibacterial peptides. Since antibacterial peptides specifically target and disrupt the integrity and function of bacterial membranes, we thought that these similar peptide sequences in the HIV envelope protein might contribute to toxicity and death in infected cells by altering cell membranes."

The team engineered the original HIV peptides for greater effectiveness and smaller size, the latter to reduce manufacturing expenses. The engineering involved modifying amino acid content (they contain just two different amino acids), peptide length, charge, and hydrophobicity. The current paper describes the third generation peptides. The lead agent contains just 12 amino acid residues.

"Another potential application is biodefense, where eCAPs may be used as a rapid postexposure aerosol treatment in individuals after exposure to aerosolized pathogens, where the goal of immediate treatment would be to rapidly reduce bacterial dose from a lethal to a nonlethal or subclinical level," says Montelaro.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
2. Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes
3. Antibacterial proteins molecular workings revealed
4. Genetic survey of endangered Antarctic blue whales shows surprising diversity
5. University of Houston study shows BP oil spill hurt marshes, but recovery possible
6. Weakness can be an advantage in surviving deadly parasites, a new study shows
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Sexual reproduction brings long-term benefits, study shows
9. UCSB study shows forest insects and diseases arrive in US via imported plants
10. Study shows botanical formula fights prostate cancer
11. Transcatheter aortic valve implantation shows promise in patients with severe aortic stenosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)...  The American College of Medical Genetics and Genomics was ... as one of the fastest-growing trade shows during the Fastest ... in Las Vegas . ... in each of the following categories: net square feet of ... attendees. The 2015 ACMG Annual Meeting was ranked 23 out ...
(Date:6/22/2016)... 22, 2016 On Monday, the Department of ... to share solutions for the Biometric Exit Program. The ... Border Protection (CBP), explains that CBP intends to add ... the United States , in order to ... imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)... 23, 2016 Andrew ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
Breaking Biology Technology: