Navigation Links
HIV dearms protective protein in cells
Date:4/15/2009

The AIDS-causing HIV specifically counteracts the mechanisms of human cells that protect these against viral infections a special viral protein marks protective cellular proteins for their rapid destruction and thus diminishes the cell's supply. A team of researchers in Heidelberg under supervision of virologist Dr. Oliver Keppler demonstrated this mechanism for the first time in cell cultures, thus discovering a target for a novel treatment strategy.

Another important discovery of the Heidelberg virologists this strategy of the human HIV is not effective in a rat model for AIDS. The protective protein in rats is immune to HIV counteraction. Consequently, HIV cannot propagate itself as easily in the animal model as in humans one limitation of the current rat model. However, this new knowledge may enable an improvement of the small animal model developed by the Heidelberg researchers. The study was published in the journal Cell Host & Microbe in March 2009.

Newly formed viruses are retained at the cell surface

In addition to the immune system, the body can activate other protective mechanisms to fight or stop virus infections the infected cells themselves dispose of several proteins that inhibit various steps of virus reproduction. In the presence of the protective protein CD317, newly formed viruses are tethered to the cell surface when they are in the process of leaving the cell and this prevents them from infecting other cells of the body. HIV overcomes this restriction by its protein Vpu by specifically counteracting this protective mechanism, which, interestingly, is effective against many types of viruses.

Dr. Keppler's team of virologists from the Department of Virology at the Hygiene Institute of Heidelberg University Hospital (Medical Director: Professor Dr. Hans-Georg Krusslich) studied how Vpu disrupts protection by CD317. They determined that in human cells in which Vpu was formed after infe
'/>"/>

Contact: PD Dr. med. Oliver T. Keppler
Oliver.Keppler@med.uni-heidelberg.de
062-215-65007
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists unlock the secrets of C. difficiles protective shell
2. Infection blocks lungs protective response against tobacco smoke
3. When our protective armor shows weakness
4. UC Riverside biochemist to study how crops can increase protein production
5. Cloud computing brings cost of protein research down to Earth
6. Penn biologists discover how silent mutations influence protein production
7. New method for detection of phosphoproteins reveals regulator of melanoma invasion
8. New therapeutic strategy could target toxic protein in most patients with Huntingtons disease
9. ISU researcher identifies protein that concentrates carbon dioxide in algae
10. Orientation of antenna protein in photosynthetic bacteria described
11. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... , June 1, 2015 According ... Touchless Sensing Market by Technology (Touch-based & Touchless), Application ... Equipment), & by Geography - Global Forecast to 2020", ... Market is expected to reach $23.55 Billion by 2020, ... Browse 83 market data T ...
(Date:6/1/2015)... , June 1, 2015 ... "Next Generation Biometrics Market by Application (Government, Military ... Travel & Immigration, and Security), Technology (Face Recognition, ... Signature Recognition, Vein Recognition, and Others), Function (Contact ... , Europe , APAC, ...
(Date:5/29/2015)... DUBLIN , May 28, 2015 ... the addition of the "Facial Recognition Market ... User - Global Forecast to 2020" report ... years, have seen facial recognition technology become more ... technology to gain traction and investment from the ...
Breaking Biology News(10 mins):Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 2Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 3Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 4Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4Global advanced Facial Recognition Market Expected to Grow From $2.77 Billion in 2015 to $6.19 Billion in 2020, at an Estimated CAGR of 17.4% 2
... the concentration of carbon dioxide in the atmosphere has been ... of this carbon by the oceans is lowering the seawater ... substance is) and aragonite saturation state in a process known ... carbonate that is laid down by corals to build their ...
... virus outbreaks can be unpredictable and devastating. But now ... developed in a Tel Aviv University lab, is poised to ... populations. Dr. Gal Almogy and Prof. Nir Ben-Tal ... George S. Wise Faculty of Life Sciences have developed a ...
... CHICAGO In the evolutionary blink of an ... into a deadly assassin responsible for the most devastating ... Yersinia pseudotuberculosis become Yersinia pestis , more ... Northwestern University Feinberg School of Medicine, with the use ...
Cached Biology News:Scientist creates new hypothesis on ocean acidification 2Watching viruses 'friend' a network 2Watching viruses 'friend' a network 3From mild-mannered to killer plague 2From mild-mannered to killer plague 3
(Date:6/2/2015)... 2, 2015  RXi Pharmaceuticals Corporation (NASDAQ: ... on discovering and developing innovative therapies primarily ... today announced that Dr. Pamela Pavco , ... the 23 rd World Congress of ... include in-depth presentations by world-class clinicians and/or ...
(Date:6/2/2015)... , June 2, 2015 GOJO, inventors of ... commitment to antibiotic stewardship at the White House Forum.  ... animal health organizations and stakeholders at the White House ... to slow the emergence of antibiotic-resistant bacteria, detect resistant ... prevent the spread of resistant infections. "A ...
(Date:6/2/2015)... June 02, 2015 German-based Moenninghoff has ... States distributor for the Moenninghoff product line . ... am pleased to announce that the R.M. Hoffman Company ... our firm, founded in 1916, this is a strategically ... is the kind of professional distributor we need to ...
(Date:6/1/2015)... , June 1, 2015  Turing Pharmaceuticals AG announced ... Oreste Salinas , MD, MSc,  has joined the ... Dr. Salinas, who holds a medical degree ... a record of significant accomplishments in the pharmaceutical ... Dr. Salinas has played a leadership role ...
Breaking Biology Technology:RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 2GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 4R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 2R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 3Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 2Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 3
... PharmaVentures announced today that it was delighted ... deal which won Scrip,s ,Outsourcing Deal of the Year 2011,. ... it was "one the largest and most comprehensive R&D alliances ... terms of the agreement, Sanofi retains access to some of ...
... BETHESDA, Md., Jan. 11, 2012   Spherix Incorporated (NASDAQ: ... therapy in diabetes, metabolic syndrome and atherosclerosis, and ... food, supplement, biotechnology and pharmaceutical companies, today reported ... study of its drug candidate, SPX-106.  Results demonstrated ...
... Calif., Jan. 11, 2012 IndustryWeek magazine today ... LIFE ) plant in Austin, Texas, one of its Top ... first biotechnology facility to win the prestigious award.  IndustryWeek ... improvement in gross margins since 2007; 94% error reduction in ...
Cached Biology Technology:PharmaVentures' Client Sanofi Wins Scrip 'Outsourcing Deal of the Year Award' 2Spherix Announces Successful Completion of Important Toxicology Study of SPX-106 2Spherix Announces Successful Completion of Important Toxicology Study of SPX-106 3Life Technologies Plant in Austin, Texas Named One of IndustryWeek's Top Ten Best Plants for 2011 2Life Technologies Plant in Austin, Texas Named One of IndustryWeek's Top Ten Best Plants for 2011 3Life Technologies Plant in Austin, Texas Named One of IndustryWeek's Top Ten Best Plants for 2011 4
... PrecisION Ion Channel Cell Lines ,High ... ,Ion channels are well known for having ... function and consequently have a key function ... that modulate ion channels have been investigated ...
Mouse monoclonal antibody raised against a partial recombinant ENTPD5. NCBI Entrez Gene ID = ENTPD5...
Mouse monoclonal antibody raised against a partial recombinant CHD8. NCBI Entrez Gene ID = CHD8...
Mouse polyclonal antibody raised against a partial recombinant SYT4. NCBI Entrez Gene ID = 6860...
Biology Products: