Navigation Links
HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
Date:3/25/2009

inone. Furthermore, it was envisioned that since thymoquinone shares a structural homology with ubiquinone (mitochondrial component) it is likely that it may act as a mitochondrial antioxidant. Indeed pretreatment of pancreatic beta-cells with thymoquinone caused a reversal of nelfinavir induced deleterious effects. Thymoquinone decreased the production of reactive oxygen species, increased the Cu/Zn SOD and glutathione levels, suppressed the UCP-2 protein levels and restored nelfinavir induced decrease in insulin secretion to normal levels in these cells. Dr. Agrawal commented, "An important finding of this study is that the dysregulation of insulin production in pancreatic beta-cells is due to generation of reactive oxygen species induced by nelfinavir, an HIV-1 protease inhibitor". Furthermore, Dr. Agrawal said, "thymoquinone, an antioxidant provided a significant protection to pancreatic beta-cells from the toxic effects of nelfinavir and therefore these findings clearly suggest a potential role for the use of black seed oil or thymoquione as a protective agent against HIV-1 protease inhibitor induced deleterious effects on pancreatic beta-cells".


'/>"/>

Contact: Dr. Krishna C. Agrawal
agrawal@tulane.edu
504-988-5444
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
2. Mutant host cell protein sequesters critical HIV-1 element
3. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
4. New inhibitor has potential as cancer drug
5. New research shows no link between aromatase inhibitors and cardiovascular problems
6. New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers
7. Scientists identify novel inhibitor of human microRNA
8. Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes
9. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
10. SinuNase Phase 3 show almost 100 percent of chronic sinusitis cases are from fungal-induced inflamma
11. New technique reveals subtle force-induced changes in biomolecules conformation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... microcontroller (MCU) and touch technology solutions, today launched the ... with the widest V cc range from ... accuracy and faster I 2 C bus communication speeds, ... EEPROM memory making them ideal for consumer, industrial, computer, ...
(Date:11/18/2014)... 18, 2014   EyeLock Inc. , a ... MorphoTrust USA (Safran), a leading U.S. ... a strategic partnership to offer comprehensive biometric identity ... (MVA), airport screening and financial services markets. ... serves consumers through a nationwide network of 1,100 ...
(Date:11/10/2014)... began appearing on U.S. store shelves in early 2010, ... since. The small packets can be tossed into a ... liquid or powder. The convenience, though, has come with ... researchers at Nationwide Children,s Hospital found that from 2012 ... 17,230 children younger than 6 years of age swallowing, ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2
... suggests that a blood clot-dissolving medication that is administered ... may help to reduce the risk of amputation following ... issue of Archives of Surgery, one of the JAMA/Archives ... for the past 25 years, according to background information ...
... nanoparticle made in a laboratory at the University of ... device for treating glaucoma, an eye disease that can ... “The nanoparticle can safely get past the blood-brain barrier ... said Sudipta Seal, an engineering professor with appointments in ...
... of infections and other diseases of the brain is ... from reaching the brain. Grantees of the National Institute ... Institutes of Health, have now shown that a short ... strip of therapeutic material into the brain via intravenous ...
Cached Biology News:Clot-dissolving agent may be beneficial in treatment of severe frostbite 2UCF nanoparticle offers promise for treating glaucoma 2Blood-brain barrier breached by new therapeutic strategy 2
(Date:11/24/2014)... One of the most extensive, widely cited digital ... now available to high school and junior college students and ... international society for optics and photonics , announced today that ... Library available to high schools for free and two-year ... to all areas of life in today’s world,” said SPIE ...
(Date:11/24/2014)... The new video, “ Save Time ... how to reduce the number of instruments on ... design can be complicated, requiring multiple chemical measurements ... and deposition. Dedicated single and dual channel transmitters ... space. Additionally, installing and maintaining each transmitter, its ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Apiscent ... supplier of fine chemical ingredients to the global ... launch of its new website, Apiscent.com. , The ... Apiscent Labs, clean design, easy navigation, rotating images ... Apiscent Labs stand out. , The ...
(Date:11/22/2014)... 21, 2014 Prominent academics, leaders ... gather on December 3rd at Genetic Rx, a ... GeneticRx will take place at the Joseph B. ... will discuss the present and future of genetic ... and gene editing—as well as the treatment of ...
Breaking Biology Technology:SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2
... introduced the world to tiny robots demonstrating soccer ... competition designed to advance microroboticsthe field devoted to ... dimensions are measured in micrometers (millionths of a ... Technology (NIST), in collaboration with IEEE, is inviting ...
... While other states jockeyed for position on Business ... its ranking as best in the Midwest and No. ... bioscience industry . , (Logo: ... bioscience ranking is in part due to updated estimates ...
... A faster tool for cell programming and a new way ... prizes of the 2009 Collegiate Inventors Competition, a program of ... Fund, the non-profit foundation of the global health care company ... Harris Wang, who invented a new way of cell ...
Cached Biology Technology:Is your microrobot up for the (NIST) challenge? 2Ohio Bioscience Industry Leads Midwest, Among Best in Nation as Investment Destination 2Winners Announced in 2009 Collegiate Inventors Competition(R) 2Winners Announced in 2009 Collegiate Inventors Competition(R) 3Winners Announced in 2009 Collegiate Inventors Competition(R) 4Winners Announced in 2009 Collegiate Inventors Competition(R) 5Winners Announced in 2009 Collegiate Inventors Competition(R) 6Winners Announced in 2009 Collegiate Inventors Competition(R) 7
Request Info...
Recombinant Mouse Serpin A1/alpha-1-Antitrypsin, CF Protein Family: Coagulation, Serine Protease Regulators...
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble...
... Since the Flp-In System creates ... produce equivalent levels of the protein ... demonstrated in Figure 3. In this ... transferase (CAT) was subcloned into pcDNA5/FRT ...
Biology Products: