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HGS announces positive Phase 2 LymphoStat-B at ACR meeting
Date:11/9/2007

measured by the SELENA SLEDAI SLE Flare Index.

  • Sustained response to LymphoStat-B therapy was independent of the type of autoantibody at baseline.

A separate poster presentation reported that LymphoStat-B also promoted progressive normalization of autoantibody, immunoglobulin and complement levels over 2.5 years of therapy in SLE patients (Stohl et al), including:

  • Stable reductions in immunoglobulins, with no increase in infections or infectious events over time.

  • Normalization of IgG in patients with elevated IgG at baseline; from 45% to 57% of patients with hypergammaglobulinemia at baseline normalized at Weeks 52-128.

  • An increase in C3 and C4 complement among patients with low complement at baseline.

  • Reversion of autoantibody levels from positive to negative (anti-dsDNA, anti-RNP, anti-Smith).


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Contact: Jerry Parrot
Jerry_Parrott@hgsi.com
301-315-2777
Edelman Public Relations
Source:Eurekalert

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