Navigation Links
HGS announces positive Phase 2 LymphoStat-B at ACR meeting
Date:11/9/2007

ROCKVILLE, Maryland November 9, 2007 Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the presentation of Phase 2 clinical results demonstrating that LymphoStat-B (belimumab) achieved a sustained improvement in disease activity across multiple clinical measures, decreased the frequency of disease flares over time, and was well tolerated through 2.5 years on treatment in combination with standard of care in patients with active systemic lupus erythematosus (SLE). The results will be the subject of an oral presentation today in Boston at the Annual Scientific Meeting of the American College of Rheumatology (ACR).

SLE is a chronic disease, and patients need new therapies that provide durable efficacy with a favorable safety profile, said Michelle A. Petri, M.D., M.P.H., Professor, Division of Rheumatology, Department of Medicine, Johns Hopkins University. The Phase 2 results presented at ACR showed that the significant clinical benefit observed for LymphoStat-B in serologically active SLE patients at 52 weeks appears to be sustained through 2.5 years. We look forward to further evaluation of LymphoStat-B in larger Phase 3 studies, which are ongoing.

A separate poster presentation of the safety profile of LymphoStat-B showed that LymphoStat-B was well tolerated in combination with SLE standard-of-care therapy during long-term exposure, with incidence rates of adverse events, serious adverse events, malignancies, infections and laboratory abnormalities remaining comparable to placebo or decreasing through 2.5 years of treatment (Merrill et al).

The results through 2.5 years confirm and extend the results reported at Weeks 52 and 76, said David C. Stump, M.D., Executive Vice President, Research and Development, HGS. At Week 52 in LymphoStat-B patients with active SLE, we saw significant reductions in SLE disease activity versus placebo as measured by the SELENA SLEDAI and BILAG indices, the Physicians Global Assessment,
'/>"/>

Contact: Jerry Parrot
Jerry_Parrott@hgsi.com
301-315-2777
Edelman Public Relations
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
2. LaserCard Corporation Announces Expansion of Middle East Project
3. BIO-key(R) Announces Contracts for New Criminal Justice Data Sharing Solution
4. Balzan Foundation announces 2007 winners
5. The American Society of Plant Biologists announces 2007 awards
6. ASPB announces Summer Undergraduate Research Fellowship 2007 recipients
7. NIST announces 56 new awards for innovative technology research and development
8. Titanium Group Announces Contract With Haitong Securities
9. Measurement Specialties, Inc. Announces Impact of German Business Tax Reform 2008 Resulting in Lower Combined German Tax Rate - Impacts 2Q08 Reported Financial Results
10. FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change
11. Positive results for airway bypass
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... A probiotic that prevents obesity could be on ... in the gut inhibit weight gain, insulin resistance ... in mice, Vanderbilt University investigators have discovered., "Of ... human," said senior investigator Sean Davies, Ph.D., assistant ... of the negative consequences of obesity in mice, ...
(Date:7/22/2014)... as disease causing agents, some viruses can perform ... shape the world we live in today, according ... of Microbiology. , "Viruses participate in essential Earth ... planet, from contributing to biogeochemical cycles, shaping the ... Marilyn Roossinck of Pennsylvania State University, a member ...
(Date:7/22/2014)... N.C. In a cost-effectiveness analysis of commercial diet ... drug Qsymia showed the best value for the money. ... but was also the most expensive option tested, according ... Medical School. , The findings, published in the June ... information on the health and weight-loss benefits per dollar ...
Breaking Biology News(10 mins):Vanderbilt study shows therapeutic bacteria prevent obesity in mice 2Report on viruses looks beyond disease 2Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3
... lives and livelihoods of some of the poorest people on ... the Times Higher Education awards ceremony in London, Dr Bhaskar ... and Civil Engineering received the Outstanding Engineering Research Team of ... in tackling the world,s worst case of ongoing mass poisoning ...
... mystery of how an abundance of fossils have been marvellously ... region of Africa has been solved by a team of ... They have established that an ancient wind brought life to ... of the dead. Sarah Gabbott, Jan Zalasiewicz and colleagues ...
... garden bird of many countries in Europe and Asia. ... it has long been known individuals vary considerably in their ... as "fast" or "proactive" are quick explorers and are ... The differences are at least in part genetically determined ...
Cached Biology News:Queen's life-saving research wins education 'Oscar' 2Bird-brained? Birds' personalities are correlated with their hormone levels 2
(Date:7/22/2014)... July 22, 2014 Dr. Williams says, ... who have recognized that the greatest health care system ... too often needlessly deadly while trying to serve the ... quasi-experts seeking to transform an enormous system that none ... Williams, in his continuing series of Open Letters ( ...
(Date:7/21/2014)... right amount of tension to a chain of carbon ... an insulator, according to Rice University scientists. , Stretching ... chain of carbon atoms -- by just 3 percent ... engineers might find useful for mechanically activated nanoscale electronics ... Boris Yakobson and his colleagues appears in the American ...
(Date:7/21/2014)... PHILADELPHIA , July 21, 2014  Mike ... closing of $1.6 million in Series Seed B ... and chemical sensors for the life science, defense, ... Trimaran Capital Partners led the round and was ... 36 Angels.  Said Patterson , "This round ...
(Date:7/20/2014)... fuel gets recycled, the process releases radioactive krypton and ... with the related gas radon. A new porous material ... July 20 in Nature Materials shows how: ... not out. , The CC3 material could be ... nuclear fuel or air in buildings and also in ...
Breaking Biology Technology:Dr. Ira Williams Asks What’s Wrong With Jonathan Bush’s Book, Where Does It Hurt? 2Carbyne morphs when stretched 2Carbyne morphs when stretched 3Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2A noble gas cage 2A noble gas cage 3
... Feb. 1, 2011 Reportlinker.com announces that a ... catalogue: Cell Therapy - Technologies, ... SummaryThis report describes and ... already started to play an important role in ...
... Feb. 1, 2011 MediVet-America today announced the ... to provide technical support for in-clinic animal stem ... Processing, Cryogenic Banking Services, Autologous Conditional Serum Processing, ... treatments. MediVet-America, the leading developer of ...
... Inspired by the popular confidence trick known as "shell ... ability to hide and shuffle "quantum-mechanical peas" microwave ... or "quantized shells." In a paper published in ... UCSB researchers show the first demonstration of the coherent ...
Cached Biology Technology:Reportlinker Adds Cell Therapy - Technologies, Markets and Companies 2Reportlinker Adds Cell Therapy - Technologies, Markets and Companies 3MediVet-America, Leading Animal Stem Cell Developer, Launches MediVet Lab Services 2UCSB physicists challenge classical world with quantum-mechanical implementation of 'shell game' 2
Request Info...
Purified Mouse anti-Hu LAT (pY226) Storage Temperature: Refrigerate(2 to 8C)...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
...
Biology Products: