Navigation Links
HGS announces positive Phase 2 LymphoStat-B at ACR meeting
Date:11/9/2007

ROCKVILLE, Maryland November 9, 2007 Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the presentation of Phase 2 clinical results demonstrating that LymphoStat-B (belimumab) achieved a sustained improvement in disease activity across multiple clinical measures, decreased the frequency of disease flares over time, and was well tolerated through 2.5 years on treatment in combination with standard of care in patients with active systemic lupus erythematosus (SLE). The results will be the subject of an oral presentation today in Boston at the Annual Scientific Meeting of the American College of Rheumatology (ACR).

SLE is a chronic disease, and patients need new therapies that provide durable efficacy with a favorable safety profile, said Michelle A. Petri, M.D., M.P.H., Professor, Division of Rheumatology, Department of Medicine, Johns Hopkins University. The Phase 2 results presented at ACR showed that the significant clinical benefit observed for LymphoStat-B in serologically active SLE patients at 52 weeks appears to be sustained through 2.5 years. We look forward to further evaluation of LymphoStat-B in larger Phase 3 studies, which are ongoing.

A separate poster presentation of the safety profile of LymphoStat-B showed that LymphoStat-B was well tolerated in combination with SLE standard-of-care therapy during long-term exposure, with incidence rates of adverse events, serious adverse events, malignancies, infections and laboratory abnormalities remaining comparable to placebo or decreasing through 2.5 years of treatment (Merrill et al).

The results through 2.5 years confirm and extend the results reported at Weeks 52 and 76, said David C. Stump, M.D., Executive Vice President, Research and Development, HGS. At Week 52 in LymphoStat-B patients with active SLE, we saw significant reductions in SLE disease activity versus placebo as measured by the SELENA SLEDAI and BILAG indices, the Physicians Global Assessment,
'/>"/>

Contact: Jerry Parrot
Jerry_Parrott@hgsi.com
301-315-2777
Edelman Public Relations
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
2. LaserCard Corporation Announces Expansion of Middle East Project
3. BIO-key(R) Announces Contracts for New Criminal Justice Data Sharing Solution
4. Balzan Foundation announces 2007 winners
5. The American Society of Plant Biologists announces 2007 awards
6. ASPB announces Summer Undergraduate Research Fellowship 2007 recipients
7. NIST announces 56 new awards for innovative technology research and development
8. Titanium Group Announces Contract With Haitong Securities
9. Measurement Specialties, Inc. Announces Impact of German Business Tax Reform 2008 Resulting in Lower Combined German Tax Rate - Impacts 2Q08 Reported Financial Results
10. FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change
11. Positive results for airway bypass
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014) Women who are poor experience higher cortisol ... elevated levels of the stress hormone, putting them ... according to a new research from the University of ... the American Journal of Human Biology , is ... it directly to the socioeconomic status of their mothers ...
(Date:8/20/2014)... to about 4,000 members, it triggers an important first ... special type of comb used for rearing male reproductive, ... of Neurobiology and Behaviour at Cornell University, led by ... honeybee colonies. The results are published in Springer,s journal ... , Reproduction isn,t always a honeybee colony,s top priority. ...
(Date:8/20/2014)... and its energy is finally utilized for the ... mostly build from silicon based semiconductors, also harness ... the development of cheaper and renewable photovoltaics consists ... protein complexes of photosynthesis. Prof. Dr. Matthias Rgner,s ... cyanobacteria that live in a hot spring in ...
Breaking Biology News(10 mins):CU Denver researcher shows economic disparities impact infant health 2Worker bees 'know' when to invest in their reproductive future 2A semi-artificial leaf faster than 'natural' photosynthesis 2
... helping scientists better understand the threatened loggerhead turtle, which is ... published today in the journal PLOS ONE describes ... technique that links chemical signatures of the turtles, diets and ... technique just as effective as expensive satellite tracking. Little ...
... (Sept. 20, 2012) The latest conference to ... focuses on the molecular mechanisms involved in exercise-mediated ... neurological, and dynamic molecular and cellular pathways. Entitled ... be held October 10-13, 2012 in Westminster, Colorado. ...
... the same DNA, but each cell,s identity is defined by ... any given moment in time. In animals, this cellular memory ... no memory and, as such, has the potential to become ... cellular memory passes from generation to generation, with potentially harmful ...
Cached Biology News:New turtle tracking technique may aid efforts to save loggerhead 2American Physiological Society's latest conference focuses on integrative biology of exercise 2American Physiological Society's latest conference focuses on integrative biology of exercise 3Pollen cells keep memory to control jumping genes 2Pollen cells keep memory to control jumping genes 3
(Date:8/20/2014)... Livermore, California (PRWEB) August 20, 2014 ... to develop and apply the most complete climate ... challenging and demanding climate change issues. , Eight ... combining forces with the National Center for Atmospheric ... in the new effort. Other participating national laboratories ...
(Date:8/20/2014)... Not long ago, it was more or ... late in the development cycle – even after the ... suggest that, like many things GxP, expectations for early ... multiple drug sponsors have been required by authorities to ... phase I/II. It’s not only clinical trial material containers ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 ... released today including improvements to the enterprise replication ... connectors for Lucene, SOLR and Elasticsearch. This release ... this high performance triplestore – GraphDB™ was formerly ... in deploying the only mature enterprise resilient RDF ...
(Date:8/19/2014)... , Aug. 19, 2014 A Geisinger researcher ... nominated for a Centers for Disease Control and Prevention ... major public health concern. Joseph Boscarino ... one of a team of researchers nominated for the ... Shepard Science Award for Data Methods and Study Design. ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... in Training and Preparing for the NFL, Combine Use SURGEX(TM) ... ... Clubs(TM), BASKING RIDGE, N.J., ... (OTC Bulletin Board: MBTG), announced today that SURGEX(TM) is,currently being administered ...
... ... * Clears Process For Phase I Clinical Later In Year ... Influenza Antigen Used Was Non-Egg-Based ... 15 Carrington,Laboratories, Inc. (OTC Bulletin Board: CARN) today announced that its,wholly owned ...
... 07/06 ... % ... 27.97 74.7 14 Other EU Countries (2) 9.66 22.4 8.22 22.0 ... 3.3 10, SLIT 34.55 ...
Cached Biology Technology:Pro Football Prospects Training at TEST Sports Clubs(TM) Use SURGEX(TM) as Part of Their Pre-Combine Training Regime 2Pro Football Prospects Training at TEST Sports Clubs(TM) Use SURGEX(TM) as Part of Their Pre-Combine Training Regime 3Pro Football Prospects Training at TEST Sports Clubs(TM) Use SURGEX(TM) as Part of Their Pre-Combine Training Regime 4GelVac(TM) Nasal Powder H5N1 (Bird Flu) Influenza Vaccine Passes Preclinical Toxicology Studies 2GelVac(TM) Nasal Powder H5N1 (Bird Flu) Influenza Vaccine Passes Preclinical Toxicology Studies 3GelVac(TM) Nasal Powder H5N1 (Bird Flu) Influenza Vaccine Passes Preclinical Toxicology Studies 4STALLERGENES: 2007: A Further Year of Strong Growth: Up 16% 2
... Ultrapure ACS Reagent Grade C 19 ... Formula Weight: 691.95 PRODUCT SPECIFICATIONS Form: Powder ... Interval: pH 3.0 - Yellow ... a tracking dye in agarose and acrylamide ...
... reads and processes raw microarray ... data for analysis. ,Package ... 1-year license for Feature Extraction ... CD-ROM containing Feature Extraction software ...
... Feature Extraction Software reads and ... to prepare microarray data for ... one 1-year license for ... accounts , * one ...
... 4 H 10 O 2 S ... SPECIFICATIONS Form: White crystalline powder Assay: ... Identity: By IR Melting Point: greater ... DTT: less than or equal to ...
Biology Products: