Navigation Links
HDAC inhibitor may overcome resistance to common breast cancer drug
Date:11/13/2011

SAN FRANCISCO Researchers have shown how estrogen receptor-positive breast cancer tumors become resistant to tamoxifen, the only approved hormonal therapy for premenopausal patients with this type of breast cancer. They also found that introducing a novel histone deacetylase inhibitor in hormone therapy treatment can overcome resistance to hormonal therapy.

"We always thought that resistance was primarily an inborn or genetic effect," said Pamela N. Munster, M.D., director of the Early-Phase Clinical Trials Program at the University of California, San Francisco. "But this is not the case. Tumors have found a way to modify their genes to become resistant. This process is called 'epigenetics,' where genes are turned on and off, but the sequence of DNA is not altered. We have also found that with this kind of breast cancer, we can prevent that resistance with histone deacetylase (HDAC) inhibitors."

Munster presented the findings at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011.

She and her colleagues found that estrogen receptor (ER)-positive breast cancer tumors alter their genes to create more AKT, a protein that spurs actions within the cell to keep it alive the opposite of what tamoxifen is designed to do.

In a preclinical study, researchers introduced the HDAC inhibitor PCI-24781 at an early phase of tamoxifen treatment and found that it reverses the tumor's survival strategy of increasing production of AKT, thus stopping the tumor cells from developing resistance and leading to higher levels of cell death.

"The HDACs regulate the response of AKT to tamoxifen, and together, the effects of HDAC inhibitors and tamoxifen lead to more cell death if introduced with hormonal therapy," said Munster.

She added that previous attempts to reverse hormone resistance were made later in the course of hormonal therapy treatment, "and we think that introducing these approaches earlier may be more successful," she said.

The next step is to take this drug into clinical trials to investigate whether resistance to therapy can be prevented in patients with ER-positive breast cancer. A new look at AKT as a biomarker may help identify patients who are likely to benefit from this type of treatment.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Team creates genetic GPS system to comprehensively locate and track inhibitory nerve cells
2. Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
3. New growth inhibitors more effective in plants, less toxic to people
4. Scientists discover that a specific enzyme inhibitor may help control lung inflammation
5. A powerful new technology to identify HIV inhibitors
6. TGen finds protein inhibitor revives chemotherapy for ovarian patients
7. Vaginal gel with integrase inhibitor shows promise in monkeys
8. ViroPharma Announces Initiation of Phase 2 Evaluation of Subcutaneous Delivery of Cinryze(TM) (C1 Esterase Inhibitor [Human])
9. KINAXO launches KinAffinity services for efficient profiling of kinase inhibitors in cells or tissue
10. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
11. Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)... , Jan. 4, 2017  CES 2017 – ... sensor technology, today announced the launch of two ... systems, the highly-accurate biometric sensor modules that incorporate ... technology, experience and expertise. The two new designs ... specifically for hearables, and Benchmark BW2.0, a 2-LED ...
(Date:12/20/2016)... and GENEVA, Dec, 20, 2016   Valencell ... sensor technology, and STMicroelectronics (NYSE: STM), a ... of electronics applications, announced today the launch of ... for biometric wearables that includes ST,s compact ... Valencell,s Benchmark™ biometric sensor system. Together, SensorTile ...
(Date:12/15/2016)... and BADEN-BADEN, Germany , December 15, 2016 ... financial services provider, today announced an agreement with NuData Security, ... to join forces. The partnership will enable clients to focus ... compliance with local data protection regulation. ... In order to provide a ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ANGELES , Jan. 23, 2017   Instrument ... Bio-Techne ( Minneapolis, MN ) the ... is the most authoritative newsletter tracking developments in ... market. "Bio-Techne consistently achieved outstanding technical, ... Tanya Samazan, Managing Editor of IBO. "In 2016, ...
(Date:1/24/2017)... 23, 2017 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... underwriting agreement with Rodman & Renshaw, a unit of ... book running manager and representative of several underwriters, under which ... commitment basis a minimum of 2,105,264 shares of common ... a minimum of 1,052,632 shares of common stock of ...
(Date:1/23/2017)... NEW YORK , Jan. 23, 2017  Spherix ... development company committed to the fostering of technology and ... its active patent infringement lawsuits. Anthony ... we enter 2017, we will continue to communicate with ... Equitable IP and our due diligence on other patent ...
(Date:1/23/2017)... CALGARY , Jan. 23, 2017 /PRNewswire/ - Resverlogix ... preliminary results from the New Zealand ... impaired patients. The data showed remarkable results in reducing ... versus healthy control patients. It is believed that this ... direct connection of this type can be made between ...
Breaking Biology Technology: