Navigation Links
HATS off to combat asthma
Date:12/4/2007

f the cell and activate messenger RNA. It is these transcription factors which activate the inflammation by causing release of mediators and cytokines.

The activation status of these transcription factors is determined by the balance between two competing groups of enzymes called histone acetyl transferase (HATs) and histone deacetylases (HDACs). In asthma and COPD sufferers the balance is altered so that the HATs are activated and HDACs suppressed with the result that inflammation is switched on. The investigators at the University think that if the balance could be restored by inactivating HATs then the mediators and cytokines will be switched off and inflammation dampened down.

By exploring plant extracts that may reduce the activation of HATs within airway cells, the researchers may isolate compounds that could be used to suppress inflammation in respiratory disease. Any drug successfully synthesised from such compounds could potentially revolutionise the treatment of respiratory disease. There is also the potential to treat other inflammatory diseases, such as rheumatoid arthritis and Inflammatory Bowel Disease.

Professor Alan Knox, of the Division of Respiratory Medicine at the University, said: The majority of people with asthma have access to reasonably good anti-inflammatory treatments that can keep their conditions under control. But up to 20 per cent of sufferers dont respond well to the treatments currently available. And when it comes to COPD, anti-inflammatory drugs arent very effective.

By tracking the process which triggers the inflammation and then identifying the compounds that inhibit or activate these crucial enzymes, we could put into motion the development of a drug which could have a huge impact on the lives of those suffering from respiratory and other inflammatory diseases.


'/>"/>

Contact: Alan Knox
alan.knox@nottingham.ac.uk
University of Nottingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. UNCCD recognizes importance of satellites for combating desertification
3. Understanding, combating foodborne pathogens E. coli 0157 and salmonella
4. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
5. Study finds a high rate of asthma in college athletes
6. Yale discovery suggests protein may play a role in severe asthma
7. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... (NASDAQ: NXTD and NXTDW) ("NXT-ID" or the ... commerce market, announces it has retained famous pickpocket, entertainer and ... CES debut of the Wocket™ biometric smart wallet.  ... booth January 6th and 7 th , 2015, demonstrating some ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has ... Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of ... feature with the iPhone 5S. It is currently the ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... -- typically a full meter across, with a bud the ... plants whose blossoms are nearly all tiny, botanists write this ... reveals that it is closely related to a family that ... plants, and the tropical root crop cassava. , The team ...
... A surprising technique to concentrate, manipulate, and separate ... identified through a collaboration between researchers at Argonne ... Arizona at Tucson, and Cambridge University, UK. This ... biomedical engineering including use in miniaturized medical diagnostic ...
... an enzyme that responds to a buildup of fatty ... in the biochemical pathway that breaks down these fatty ... Hospital. This breakdown of fatty acids, in turn, provides ... fatty acids will accumulate. , The St. Jude ...
Cached Biology News:World's largest flower evolved from family of much tinier blooms 2World's largest flower evolved from family of much tinier blooms 3Researchers develop technique for bacteria crowd control 2Protein sensor for fatty acid buildup in mitochondria 2
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer Experience ... Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and ... of revenues. , Browse 152 market data tables, ... on “Service Quality Management (SQM) and Telco Customer Experience ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... St. Louis, Missouri (PRWEB) December 23, 2014 ... Swiss biotechnology company, Syngenta, are in the process of being ... consolidated case is In Re: Syngenta AG MIR 162 Corn ... the District of Kansas. , Management of the Syngenta GMO ...
(Date:12/24/2014)... On Friday, December 19, 2014, President ... Continuing Resolution Appropriations Act of 2015, which for the ... funding through the Congressionally Directed Medical Research Programs (CDMRP) ... Association (HA), working in conjunction with its allies on ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... over Internet Protocol, or VoIP, may have found the missing ... a lot of telephone companies go into a state of ... ,The telcos and cable companies are both trying to figure ... voice over the Internet and to be able to connect ...
... YellowTop battery. Courtesy of Optima Batteries. Milwaukee ... Milwaukee-based Johnson Controls , has announced the latest ... introduction of the dual-purpose Group 75/25 and 35 models. ... on vehicles by a growth of in-car electronics. , ...
... magazines recently released list of the top 100 ... A. Graham, vice president and CIO of Church Mutual ... to religious organizations, including churches as well as schools, camps ... 50 states. , , Herman Nell, senior vice president and ...
Cached Biology Technology:The day the old telephony died 2The day the old telephony died 3Computerworld: Three Wisconsin CIOs among top 100 IT leaders 2
Potassium Channel kv3.2...
200 μg per ml DNA in 10 SSPE, 2 Denhardt's...
MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
MAb to Vasopressin Preservative: NaN3...
Biology Products: