Navigation Links
HATS off to combat asthma
Date:12/4/2007

Two University of Nottingham studies exploring the causes and treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD) could lead to the development of drugs to battle these debilitating conditions.

The Division of Respiratory Medicine at the University has been awarded a total of 1.24m in grants to study respiratory disease. The Wellcome Trust has awarded Prof Alan Knox and Dr Linhua Pang 700,000 to research transcriptional control of inflammatory gene expression in asthma allowing the team to examine the part inflammatory mediators play in the way asthma sufferers react to allergens. A second grant of 540,000 from MRC to Prof Knox and his colleagues Prof Peter Fischer and Prof David Heery will explore histone acetyl transferase (HAT) inhibitors in asthma and COPD. This study will investigate a bank of plant extracts at the University of Strathclyde, seeking compounds that could combat the intercellular processes that result in the symptoms of asthma and COPD inflammation of the airways which can lead to coughing, breathlessness and increased chest infections.

Though they are different diseases, asthma and COPD affect the human body in a similar way. In asthma, allergens irritate the lungs, in COPD, this is done by cigarette smoke. This irritation inflames the sufferers airways, which the muscles then close, creating a narrowing effect.

Research done at the University over the past 15 years has found that the muscle layer in the airway is more complex than has traditionally been thought. As well as going into spasm during asthma and COPD attacks the muscle layer produces a wide range of mediators and cytokines proteins that act as chemical signallers when it comes into contact with allergens or cigarette smoke. In asthma and COPD sufferers, these proteins are produced by stimulation of airway muscle cell walls in the lungs, releasing intracellular signalling proteins called transcription factors which alter the DNA o
'/>"/>

Contact: Alan Knox
alan.knox@nottingham.ac.uk
University of Nottingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural chemical found in broccoli helps combat skin blistering disease
2. UNCCD recognizes importance of satellites for combating desertification
3. Understanding, combating foodborne pathogens E. coli 0157 and salmonella
4. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
5. Study finds a high rate of asthma in college athletes
6. Yale discovery suggests protein may play a role in severe asthma
7. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has ... - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally different ... the first time a fingerprint sensor in its product. ...
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... has identified a mechanism related to a transcription factor ... variant, thereby initiating a genetic programme which enhances prostate ... important new direction in investigating the mechanisms related to ... risk of prostate cancer and other human diseases. Published ...
... Japan joined forces in a quest to correct a faulty ... Nature , used stem cells to correct a defective ... promise to correct chromosome abnormalities that give rise to birth ... future, it may be possible to use this approach to ...
... 2014 -- Scientists have identified a mutated gene that ... can have devastating lifelong effects. Currently, the tumor can ... The discovery, reported in Nature Genetics , ... the tumors with targeted drugs already in use for ...
Cached Biology News:Nature study discovers chromosome therapy to correct a severe chromosome defect 2Nature study discovers chromosome therapy to correct a severe chromosome defect 3Mutation discovery may improve treatment for rare brain tumor type 2
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... SoundConnect’s 2015 next ... edge communication technology, provide continued education and inform ... series demonstrates online communication features and benefits; empowering ... most innovative and powerful tools. , According to ...
(Date:12/24/2014)... 2014 According to Ross Selinger, President of ... ITRA Global, the national office market continues to be strong, ... is evidenced by the third quarter’s surprising 3.9% GDP, unemployment ... energy costs have held inflation down and the Fed is ...
(Date:12/24/2014)... Nashville, Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for Reproductive Medicine ... research in reproductive medicine. In his new role as ... board and will have a voice in furthering the mission ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... health officials may not be saying it, but they are ... the deadly avian flu virus begins quietly in scattered areas ... handle on it - with substantial harm done to public ... and one that is exacerbated by the lack of an ...
... - Last Sunday morning, in the free-wheeling environment ... shared secrets and strategies from her forthcoming book, titled ... she expects to publish next year. , ,In her ... Huber provided advice about maximizing efficiency and minimizing hurt ...
... including one from California, to stem cell patents held ... lack merit and underscore the need for serious patent ... of challenging patents, such as those held by WARF, ... the United States Patent and Trademark Office ...
Cached Biology Technology:UW compound counters Avian flu 2UW compound counters Avian flu 3BarCamp talk turns to Internet dating 2BarCamp talk turns to Internet dating 3WARF challenges show need for patent reform 2WARF challenges show need for patent reform 3WARF challenges show need for patent reform 4
... Immunodepletion Kit specifically removes 20 of the ... serum in preparation for further proteomics analysis. ... plasma proteome whether you use one- or ... go straight to mass spectrometry. This is ...
... • Small design specifically for western ... ,Trays are specifically designed for staining western ... x 25 mm) of the disposable tray ... a significant cost savings to the user. ...
... the industry's first siRNA sequence design software ... keep these tools consistent with new experimental ... field of RNAi. With the introduction ... design tools, OligoEngine is pleased to offer ...
... The Gene Inspector can perform many sophisticated ... software is much more than just another sequence ... an entire suite of analyses to be performed ... to design custom style sheets which specify exactly ...
Biology Products: