Navigation Links
H7N9 influenza strain resistant to antivirals, but tests fail to identify resistance
Date:7/15/2013

testing gave misleading results, says Webster, because the functioning wild-type enzymes masked the presence of the non-functioning mutant enzymes.

Using NA inhibitors to treat a patient infected with a resistant strain of H7N9 only encourages the virus to proliferate and can lead to enhanced spread of the resistant strain. The authors write that these results prove that it is crucial to use a gene-based surveillance technique that can detect these resistant influenza strains in a mixed infection.

H7N9 first emerged in China in early 2013, in some cases infecting individuals who had been in contact with poultry or with places where poultry are housed. The virus has since been detected in poultry at live markets near where human infections have been reported. After the closure of many live poultry markets in China and with the start of the warm season, which is not conducive to influenza spread, the infection rate appears to have slowed. As of July 12, the number of infections stands at 132 and the number of deaths at 43.

A recent study found that antiviral treatment failed in two patients infected with a strain of H7N9 influenza that carries a mutation called R292K, and that these patients had a poor clinical outcome. The mutation causes a change in the neuraminidase gene and makes the virus resistant to neuraminidase (NA) inhibitors, including Tamiflu and Relenza. NA inhibitors have been the front line therapeutic option for treating H7N9 influenza because the virus is already resistant to M2 ion channel blockers Amantadine (Symmetrel) and its methyl derivative Rimantadine (Flumadine). Considering the severity of H7N9 flu infection and the fact that so few options exist for treatment, it is important to continue to evaluate the sensitivity of clinical isolates to NA inhibitors and to monitor for the emergence of resistant variants.

If the recent history of H5N1 influenza is a guide, says Webster, then H7N9 could rapidly evolv
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Target for potent first-strike influenza drugs identified
2. Climate change could increase levels of avian influenza in wild birds
3. Harnessing anticancer drugs for the future fight against influenza
4. Influenza research: Can dynamic mapping reveal clues about seasonality?
5. Pandemic controversies: The global response to pandemic influenza must change
6. Influenza study: Meet virus new enemy
7. Cleverly designed vaccine blocks H5 avian influenza in models
8. Source identification of H7N9 influenza virus causing human infections
9. University of Maryland School of Medicine researchers find potential novel treatment for influenza
10. Evidence of host adaptation of avian-origin influenza A virus
11. Saliva proteins may protect older people from influenza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... DUBLIN , Mar. 20, 2015 Research ... announced the addition of the "India Sensors ... their offering. The sensor market is ... through 2020 Consumer electronics, automotive, industrial ... for sensors in the country. In addition, adoption ...
(Date:3/18/2015)... Florida , March 18, 2015 ... as businesses, new revolutionary smart wallets and apps continue to ... Companies currently entrenched in the mobile payment industry in focus ... Group Holding Ltd. (NYSE: BABA ), Apple Inc. ... GOOG ) and Facebook Inc. (NASDAQ: FB ) ...
(Date:3/12/2015)... -- IriTech, a leading iris based identity management technology ... Design Network, announced today that the Chief Minister ... MK2120U device during a launching event of Andhra Pradesh ... The iris scanner is manufactured by U.S. based ... India through its Indian partner, Biometronic Technology, ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3
... Disease Models & Mechanisms, one-day symposium entitled Protein-Folding ... one-day Symposium will focus on how misfolded proteins ... cellular and whole-organism level, highlighting the diverse biological ... issue. It is becoming increasingly clear that protein ...
... birds and fish use the Earth,s magnetic field to ... with internal compass needles for the perception of the ... the magnetic orientation. Although many animal species can ... orientation, efforts to pinpoint the cells that detect the ...
... twists and turns of rivers can easily be seen. In ... vessels is difficult, but important. Vessel "bendiness" can indicate the ... UNC scientists to a new method of using a high-resolution ... method, based on vessel bendiness or "tortuosity," potentially offers an ...
Cached Biology News:The magnetic sense 2Preclinical studies use specialized ultrasound to detect presence of cancer 2
(Date:3/26/2015)... 2015 The Market Element LLC, a ... alliance with Designing Gig LLC to provide website design, ... , “Forging this alliance with Designing Gig represents a ... extend a comprehensive, end-to-end, digital solution for our clients, ... said Chuck Miller, president of The Market Element. “For ...
(Date:3/26/2015)... LANSING, Mich., March 26, 2015 Neogen Corporation ... income for the third quarter of fiscal 2015, which ... to the prior year,s $6,575,000. Earnings per share in ... year ago. Current year-to-date net income increased 17% over ... to $20,621,000, or $0.56 per share, for the same ...
(Date:3/26/2015)... "In America," the popular news television program that ... hosted by legendary film actor James Earl Jones, has announced ... upcoming segment. , Botany is commonly described as the ... quite a bit more complicated than that. Scientists and other ... organisms, from the smallest bacteria known to man to the ...
(Date:3/25/2015)... pharmaceutical market is one of the most ... its absolute size, plus a growing economy and increasing ... Business Monitor International. The Russian market is set to ... market, with growth estimates around 10-15% annually reaching an ... About Green Cross Green Cross provides ...
Breaking Biology Technology:The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8
... , ... Researchers in New Brunswick Scientific's ... high antibiotic expression levels in a pilot-scale fermentation process ... with,touchscreen interface augmented by the powerful supervisory capabilities of ...
... , ... new cell-growth matrix that dramatically increase yields in packed-bed reactors, and,have ... bags. New Brunswick,Scientific offers two new devices that use FibraCel disks ... system that outperforms spinners, T-flasks and roller bottles, and the CelliGen ...
... , Many of ... application in cell culture and fermentation. ... or antigen from a sample (from,serum, for example) by adding the corresponding antigen or ... of substances in solution or suspension, to ...
Cached Biology Technology:Rapamycin Optimized in 100 Liter Fermentor Using BioCommand Control Strategys 2Rapamycin Optimized in 100 Liter Fermentor Using BioCommand Control Strategys 3A technique for increasing yields in bioreactors and disposable cell-culture systems 2A technique for increasing yields in bioreactors and disposable cell-culture systems 3A technique for increasing yields in bioreactors and disposable cell-culture systems 4Glossary for The BioPharm Guide to Fermentation and Cell Culture 2Glossary for The BioPharm Guide to Fermentation and Cell Culture 3Glossary for The BioPharm Guide to Fermentation and Cell Culture 4Glossary for The BioPharm Guide to Fermentation and Cell Culture 5Glossary for The BioPharm Guide to Fermentation and Cell Culture 6Glossary for The BioPharm Guide to Fermentation and Cell Culture 7Glossary for The BioPharm Guide to Fermentation and Cell Culture 8Glossary for The BioPharm Guide to Fermentation and Cell Culture 9Glossary for The BioPharm Guide to Fermentation and Cell Culture 10Glossary for The BioPharm Guide to Fermentation and Cell Culture 11Glossary for The BioPharm Guide to Fermentation and Cell Culture 12Glossary for The BioPharm Guide to Fermentation and Cell Culture 13Glossary for The BioPharm Guide to Fermentation and Cell Culture 14Glossary for The BioPharm Guide to Fermentation and Cell Culture 15Glossary for The BioPharm Guide to Fermentation and Cell Culture 16
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
... HT, 1 kit. Facilitates the simple, phenol-free ... and hard tissue requiring proteinase K digestion.Each ... DNA from 50 preparations of up to ... Synthesis & Purification, Purification and Amplification of ...
... For rapid and efficient purification of DNA ... 15 minutes by gravity flow.Prepacked with Sephadex ... 0.15% Kathon CG/ICP Biocide.Available in three sizes ... (NAP-5), 1 ml (NAP-10) or 2.5 ml ...
Human ROR1 Affinity Purified Polyclonal Ab...
Biology Products: