Navigation Links
H1N1 pandemic points to vaccine strategy for multiple flu strains
Date:1/10/2011

, stalk-reactive antibody was thought to be very rare," Wrammert said. "In contrast, in the patients we studied, these stalk-reactive antibodies were surprisingly abundant."

The team tested whether three of their cross-reactive antibodies could protect mice against the 2009 strain or two other common lab strains. Two antibodies protected mice against an otherwise lethal dose of any of the three strains, even when the antibody was given 60 hours after infection.

One antibody, from the patient with the most severe illness, only protected against the 2009 H1N1 strain. The antibody genes from that patient suggest that the patient had a complete lack of preexisting immunity to H1N1 viruses. In cases where patients experienced a milder illness, it appears that immune cells that developed in response to previous seasonal flu shots or infections formed a foundation of response to 2009 H1N1 strain.

Although relatively few patients could be analyzed in detail at the antibody level, the authors conclude that "with the proper immunogen, the long-sought development of a pan-influenza vaccine might be possible."

Next, the research team is planning to examine the immune responses of people who were vaccinated against the 2009 H1N1 strain but did not get sick to see if they also produce antibodies that protect against many influenza strains.


'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rethinking who should be considered essential during a pandemic flu outbreak
2. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
3. New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists
4. Swine flu genes dissimilar to past pandemics
5. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
6. K-State researcher, collaborators study virulence of pandemic H1N1 virus
7. Pandemic flu can infect cells deep in the lungs, says new research
8. Excellence in Paediatrics conference line-up includes WHO and CDC pandemic speakers
9. £7.5 million ($12.6 million) collaborations lead UK research communitys response to H1N1 pandemic
10. Short-term school closures may worsen flu pandemics, Pitt study finds
11. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... in your popcorn or soap might not be ape friendly, ... to an analysis in the Cell Press journal Current ... vegetable oil has already led to the conversion of Southeast ... in particular. If guidelines are not put in place very ... from Asia into Africa will be bad news for great ...
(Date:7/10/2014)... Marshall Institute for Interdisciplinary Research (MIIR) and the ... today announced they will be partnering with an ... , Under the agreement with Shanghai-based HD Biosciences ... costs and risks of discovery and development of ... any intellectual property and commercialization rights to products ...
(Date:7/10/2014)... Amidst the astounding complexity of the billions of ... brain, how do nerve cells decide how far to ... they coordinate these events within the developing brain? , ... of The Scripps Research Institute (TSRI) have shed new ... protein plays a far more sophisticated role in neuron ...
Breaking Biology News(10 mins):Hunger for vegetable oil means trouble for Africa's great apes 2Marshall University to partner with international company in drug development venture 2Scripps Florida scientists shed new light on nerve cell growth 2
... researchers have identified the neurocircuit that controls the brain's ... be possible to understand psychiatric disorders, such as anxiety ... brain. , They accomplished this using an adapted version ... that enables analysis of function in the brain. , ...
... the January/February 2007 issue of Physiological and Biochemical Zoology, ... may respond to water diversion and climate change. Endangered ... spawn, and a lake in Western China, where they ... and becoming increasingly more saline--leading to surprising adjustments to ...
... blood oxygen levels of a baby during labor--expected to ... benefit, report researchers in a National Institutes of Health ... saturation monitoring, was designed for use along with electronic ... measure changes in fetal oxygen levels. Designers of ...
Cached Biology News:Emotional control circuit of brain's fear response discovered 2Emotional control circuit of brain's fear response discovered 3Climate change has surprising effect on endangered naked carp 2Technology for monitoring fetal oxygen during labor offers no apparent benefit 2Technology for monitoring fetal oxygen during labor offers no apparent benefit 3
(Date:7/10/2014)... D.C., April 15, 2014 -- According to the ... to nuclear security comes from terrorists acquiring sufficient ... to construct a crude nuclear explosive device. The ... nuclear trafficking have involved gram-level quantities, which can ... , According to a new study appearing this ...
(Date:7/10/2014)... fractional quantum Hall effect in bilayer graphene and shown ... by an electric field. , The fractional quantum ... thin sheets are exposed to large magnetic fields, is ... individual electrons behave as a single system. However, while ... many details of this collective behavior remain not well ...
(Date:7/10/2014)... will see the two universities and NPL collaborate to ... and industry and their complementary academic strengths., Working with ... shape the scientific priorities of the UK. The establishment ... 300 high-calibre PhD students, will provide a pipeline of ... potential of the Laboratory will be grown through the ...
(Date:1/15/2014)... 15, 2014   Niagara Thermal Products is proud ... BioBlower Technologies LLC ("B3") as the critical thermal component ... from the Army Corps of Engineers.  B3 has developed ... biological contaminants and destroys VOCs and other chemical pollutants, ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
... QUEBEC CITY, Oct. 23 /PRNewswire-FirstCall/ - AEterna Zentaris ... "Company") a global biopharmaceutical company focused on endocrine ... completed its previously announced registered direct offering of ... and common share purchase warrants to certain institutional ...
... A team of engineers from the University of ... and circuits, demonstrating a novel, self-assembling method for ... to grow or obtain otherwise. The research ... into a variety of useful, nanoscale materials including ...
... Tolerx, Inc., a biopharmaceutical company developing novel therapies intended ... specifically modulating T-cell activity, today presented dose optimization data ... subjects with type 1 diabetes. Otelixizumab is a targeted ... 3 clinical study in subjects with new-onset autoimmune type ...
Cached Biology Technology:AEterna Zentaris Receives US$5.5 Million from Institutional Investors 2AEterna Zentaris Receives US$5.5 Million from Institutional Investors 3Penn study: Transforming nanowires into nano-tools using cation exchange reactions 2Penn study: Transforming nanowires into nano-tools using cation exchange reactions 3Tolerx Presents Otelixizumab Phase 2 Dose Optimization Data At The IDF's 20th World Diabetes Congress 2Tolerx Presents Otelixizumab Phase 2 Dose Optimization Data At The IDF's 20th World Diabetes Congress 3
KRIT1 Immunogen: KRIT1 (NP_004903, 637 a.a. ~ 737 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Evolutionarily conserved signaling intermediate in Toll pathway...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Sheep polyclonal to Streptomycin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule: Streptomycin conjugated to BSA....
Biology Products: