Navigation Links
H1N1 pandemic points to vaccine strategy for multiple flu strains
Date:1/10/2011

"

When the study began, there was no vaccine for the novel 2009 H1N1 strain. The researchers hoped to use the antibodies from patients who recovered as therapy for those who were severely ill with this emerging virus.

The researchers began by analyzing antibody responses from nine patients recruited through the Hope Clinic, the clinical division of the Emory Vaccine Center. In these patients, ages 21 to 45 years old, the virus caused a range of illness, from mild to life-threatening disease.

The researchers identified white blood cells from the patients that made antibodies against the virus, then isolated antibody genes from individual cells. They used the genes to produce antibodiesa total of 86 varietiesand then tested which flu strains the antibodies reacted against.

Five antibodies isolated by the team could bind all the seasonal H1N1 flu strains from the last decade, the devastating "Spanish flu" strain from 1918, plus a potentially lethal H5N1 avian flu strain.

This indicated that "while the flu changes from year to year, some core elements have been consistent for nearly a century," said Wilson.

The cross-reactive antibodies were produced by highly mutated antibody genes. These antibodies appear to have been produced by white blood cells that had been exposed to influenza in previous years and were reactivated by a new viral infection. As the antibody genes, developed to combat one strain, adapted to a new infection, they continued to mutate, increasing their affinity for certain key targets present on both strains.

Half of the cross-reactive antibodies the team identified attached to the virus's "stalk" region, a sort of biochemical drill-bit the virus uses to enter cells. Because this part of the virus doesn't change as much as other regions, scientists have proposed to make it the basis for a vaccine that could provide broader protection.

"Previously, this type of broadly protective
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rethinking who should be considered essential during a pandemic flu outbreak
2. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
3. New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists
4. Swine flu genes dissimilar to past pandemics
5. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
6. K-State researcher, collaborators study virulence of pandemic H1N1 virus
7. Pandemic flu can infect cells deep in the lungs, says new research
8. Excellence in Paediatrics conference line-up includes WHO and CDC pandemic speakers
9. £7.5 million ($12.6 million) collaborations lead UK research communitys response to H1N1 pandemic
10. Short-term school closures may worsen flu pandemics, Pitt study finds
11. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... over 100 diseases that can attack soybean crops, why ... most wanted list? University of Illinois scientists cite the ... is needed on the fungus that causes charcoal rot. ... growing conditions but Macrophomina phaseolina , the fungus ... conditions. , "As the climate continues to change and ...
(Date:7/9/2014)... cooks are turning to more healthful alternatives to their ... sometimes mean low satisfaction. Now researchers are reporting new ... that are made with olive oil rather than pork ... of Agricultural and Food Chemistry . , Ana M. ... to expect just the right amount of chewiness and ...
(Date:7/9/2014)... global census of Adlie penguins shows that the ... percent larger than previously estimated. Adlie penguins have ... monitor and understand the effects of climate change ... using high-resolution satellite imagery, researchers from Stony Brook ... new method that permits regular monitoring of Adlie ...
Breaking Biology News(10 mins):Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
... in native plants increases, nursery growers are challenged to ... to their collections. Surveys have indicated that landscape architects ... plants, but that a broad palette of native plants ... to capitalize on the native plant market are looking ...
... now shown that adult women with anorexia whose disorder ... an out-patient basis. Even after conclusion of therapy, they ... methods offer improved opportunities for successful therapy. However, one ... not show rapid results. These are the findings of ...
... Institute of Medicine of the National Academies honored members Donald ... outstanding service today at the IOM,s 43rd annual meeting. ... an IOM member for distinguished service over an extended period. ... of Health Care in America, which produced the landmark reports ...
Cached Biology News:New native shrubs show promise for landscape, nursery industries 2Largest therapy trial worldwide: Psychotherapy treats anorexia effectively 2Largest therapy trial worldwide: Psychotherapy treats anorexia effectively 3Largest therapy trial worldwide: Psychotherapy treats anorexia effectively 4Institute of Medicine honors members for outstanding service 2Institute of Medicine honors members for outstanding service 3
(Date:1/15/2014)... (PRWEB) January 15, 2014 More than ... and about 1 in 3 seniors will die with ... ). These jaw-dropping figures have shocked many Americans into ... hopefully, help prevent these tragic age-related cognitive disorders. Jonathan ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company developing ... simulated embryonic conditions, today announced that they have entered ... for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent cell ... an amendment to the existing license between Histogen and ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... May 22, 2012 Genesis Biopharma, Inc. (OTC/BB: ... was mentioned favorably in an article in BioMedReports ... accessed at the following link: ... Inc. Genesis Biopharma, Inc. ...
...  Paratek Pharmaceuticals, Inc. today announced that Dennis ... been appointed President, Chief Executive Officer and Director, ... resignation earlier this year.  In addition, Evan Loh, ... Wyeth and who led regulatory approval for the ...
... of reflective metal can actually make something less visible, engineers ... invisible, light-detecting device that can "see without being seen." ... by a thin cap of gold. By adjusting the ratio ... to as tuning the geometries they capitalize on favorable ...
Cached Biology Technology:Genesis Biopharma Mentioned Favorably in BioMedReports Article 2Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 2Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 3Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 4Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 5Cloak of invisibility: Engineers use plasmonics to create an invisible photodetector 2Cloak of invisibility: Engineers use plasmonics to create an invisible photodetector 3
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
... Expansion Kit - Monolayer is a system designed ... a monolayer in a serum-free environment. The kit ... which has been optimized for neural stem cell ... Genes & Development 10 :3129). Human fibroblast ...
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
... Avian Myeloblastosis Virus Reverse Transcriptase (AMV ... template DNA, RNA or RNA:DNA hybrids (1). ... more efficient than RNA primers) as well ... an intrinsic RNase H activity. Both nonionic ...
Biology Products: