Navigation Links
H1N1 influenza adopted novel strategy to move from birds to humans
Date:12/8/2009

re efficient in human cells.

"This is an extremely rare mutation and a rare combination, which suggests that there may be other ways that haven't emerged yet that these viruses are going to continue to evolve," said Jennifer Doudna, UC Berkeley professor of molecular and cell biology and an investigator in the Howard Hughes Medical Institute.

"As mechanistic biologists, we are hoping that by understanding how the virus works at the molecular level, we will be able to predict with more accuracy how it will evolve."

She suggested that those monitoring influenza outbreaks around the world in search of new variants be on the lookout for this recombination of polymerase subunits, which could herald an uptick in swine flu virulence. The findings also could help scientists develop better antiviral treatments, Mehle and Doudna said.

"The more we can understand the biochemistry and the particular structure of these polymerase complexes, the better we can make rational decisions about drug development," Mehle said.

H1N1, which appeared on the scene earlier this year, was dubbed swine flu because it emerged from pigs, in which human, bird and pig influenza viruses mixed, swapped genes and gave rise to a variant that could infect human cells and reproduce.

While mutations in the surface protein hemagglutinin indicated by the H in H1N1 are key to allowing the virus to enter human cells, mutations in the polymerase enzyme are key to the virus's ability to replicate inside human cells. All previous flu strains that entered and were transmitted in humans had a single mutation in the second subunit of the bird polymerase gene, which apparently allowed the enzyme to operate in human cells.

Last year, Mehle and Doudna showed that human cells apparently prevent the three subunits of bird virus polymerases from assembling into a functioning enzyme. A single amino acid switch at position 627 on the second subunit of
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. St. Jude influenza survey uncovers key differences between bird flu and human flu
2. New field-deployable biosensor detects avian influenza virus in minutes instead of days
3. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
4. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
5. Getting wise to the influenza virus tricks
6. Tracking influenzas every movement
7. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
8. Genetic evidence for avian influenza movement from Asia to North America via wild birds
9. K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
10. SRI International to screen drugs that fight 2009 H1N1 influenza A
11. The challenges of avian influenza virus: Mechanism, epidemiology and control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... , July 30, 2014 ... mitigation and liveness detection solutions for the biometric ... an industry consortium revolutionizing online authentication with standards ... Mark Cornett , "The decision to join FIDO ... biometric authentication pervasive in use. We believe the ...
(Date:7/30/2014)... Portland Press Limited today announced an across-the-board increase ... , The 2013 InCites Journal Citation Reports (Thomson ... Biochemical Journal , Essays in Biochemistry ... Bioscience Reports all received increases in their ... Biochemical Society and published by Portland Press Limited. ...
(Date:7/30/2014)... Americans make better decisions about what they eat, the ... significant changes to the Nutrition Facts label found on ... in Chemical & Engineering News (C&EN), the ... the suggested updates and the fight that has ... points out that while the Nutrition Facts label has ...
Breaking Biology News(10 mins):NexID Biometrics Joins the FIDO Alliance 2Across-the-board Impact Factor increases for Portland Press Limited 2
... locations with central nervous system infections may well be suffering ... a study to be published in mBio , the ... have detected the virus in spinal fluid from 4 percent ... cause, and in an average of 58 percent of fecal ...
... LOUIS -- In research published in Biochemical and ... a technology that can detect new, previously unknown viruses. ... viruses even when doctors have not identified a particular ... In the new approach, scientists use blood ...
... research associate has received a prestigious fellowship to support ... spread of malaria. Bart Bryant, research associate in ... Research Service Award Individual Postdoctoral Fellowship, which provides $113,000 ... University researcher to receive the award and is the ...
Cached Biology News:New virus discovered in patients with central nervous system infections 2New virus discovered in patients with central nervous system infections 3Saint Louis University researchers discover a way to detect new viruses 2Saint Louis University researchers discover a way to detect new viruses 3NIH fellowship helps researcher fight malaria, understand mosquito immunity 2
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... These bearings are uniquely suited to prevent loss of ... of the high temperatures . , Recently, a ... design engineers at Graphite Metallizing to overcome problems with ... manufacturing operation, pans containing blocks of powder mixture are ...
(Date:7/31/2014)... , July 31, 2014 Research ... "Global Genomics Market 2014-2018" report to their ... Genomics is the study of the genetic material ... be a strong basis for the discovery and development ... human diseases or health conditions. Genomics is supported by ...
(Date:7/31/2014)...  Smith & Nephew (LSE:SN, NYSE: ... announced its entry into the forefoot market with ... System. Comprised of three separate repair options, the ... repair and reconstruction, a metatarsal osteotomy guide, and ... fusion, also known as hammer toe correction. ...
(Date:7/31/2014)... CA (PRWEB) July 31, 2014 ... today the integration of Omicsoft’s Array Suite with ... platforms will be able to send data in tranSMART ... works with all versions of tranSMART including the new ... art statistics, visualization and storage for the analysis of ...
Breaking Biology Technology:Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3
... Findings Presented at American Academy of Pediatrics National Conference & ... ... and EAST NORRITON, Pa., Oct. 29 Tengion,Inc., a leader in ... today at the American Academy of,Pediatrics (AAP) National Conference and Exhibition ...
... 29 Cliniqa Corporation (San,Marcos, CA), a ... to,announce the acquisition of the primary assets ... a wholly owned subsidiary of Hemagen,Diagnostics, Inc. ... clinical,diagnostic products focusing on clinical chemistry reagents, ...
... American Society of Plastic Surgeons ... ... NBC,s,"Bionic Woman," the notion of a bionic person is thought of ... reality,as reconstructive plastic surgeons perform quality-of-life-enhancing,peripheral nerve surgeries once thought impossible. ...
Cached Biology Technology:Preclinical Efficacy Data Demonstrate Ability of Tengion's Neo-Bladder Augment to Restore Bladder Function 2Preclinical Efficacy Data Demonstrate Ability of Tengion's Neo-Bladder Augment to Restore Bladder Function 3Cliniqa Corporation Completes Asset Acquisition of Reagents Applications, Inc. 2Creating the Bionic Woman: Making Nerves Spring Back to Life 2Creating the Bionic Woman: Making Nerves Spring Back to Life 3
... The AccuSpot automates LC microfractionaction, spotting ... With the AccuSpot system, LC eluent can ... plates, in trace amounts (eg.50nl). Matrix solutions ... automatic preparation of target plated for MALDI-TOF-MS ...
Glycerokinase; from Bacillus stearothermophilus...
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
...
Biology Products: