Navigation Links
H1N1 influenza adopted novel strategy to move from birds to humans
Date:12/8/2009

re efficient in human cells.

"This is an extremely rare mutation and a rare combination, which suggests that there may be other ways that haven't emerged yet that these viruses are going to continue to evolve," said Jennifer Doudna, UC Berkeley professor of molecular and cell biology and an investigator in the Howard Hughes Medical Institute.

"As mechanistic biologists, we are hoping that by understanding how the virus works at the molecular level, we will be able to predict with more accuracy how it will evolve."

She suggested that those monitoring influenza outbreaks around the world in search of new variants be on the lookout for this recombination of polymerase subunits, which could herald an uptick in swine flu virulence. The findings also could help scientists develop better antiviral treatments, Mehle and Doudna said.

"The more we can understand the biochemistry and the particular structure of these polymerase complexes, the better we can make rational decisions about drug development," Mehle said.

H1N1, which appeared on the scene earlier this year, was dubbed swine flu because it emerged from pigs, in which human, bird and pig influenza viruses mixed, swapped genes and gave rise to a variant that could infect human cells and reproduce.

While mutations in the surface protein hemagglutinin indicated by the H in H1N1 are key to allowing the virus to enter human cells, mutations in the polymerase enzyme are key to the virus's ability to replicate inside human cells. All previous flu strains that entered and were transmitted in humans had a single mutation in the second subunit of the bird polymerase gene, which apparently allowed the enzyme to operate in human cells.

Last year, Mehle and Doudna showed that human cells apparently prevent the three subunits of bird virus polymerases from assembling into a functioning enzyme. A single amino acid switch at position 627 on the second subunit of
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. St. Jude influenza survey uncovers key differences between bird flu and human flu
2. New field-deployable biosensor detects avian influenza virus in minutes instead of days
3. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
4. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
5. Getting wise to the influenza virus tricks
6. Tracking influenzas every movement
7. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
8. Genetic evidence for avian influenza movement from Asia to North America via wild birds
9. K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
10. SRI International to screen drugs that fight 2009 H1N1 influenza A
11. The challenges of avian influenza virus: Mechanism, epidemiology and control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
(Date:4/1/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces the second shipment of ... to early access pre-order customers. Feedback ... outlets including Walmart, Target, AT&T, Dunkin, Donuts, Stop & ... at all outlets and very easy to use. Several ...
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... the "Global Gesture Recognition Market in Automotive Sector ... analysts forecast the Global Gesture Recognition market in Automotive ... the period 2013-2018. Gesture recognition is the ... different gestures of an individual. Gesture recognition technology can ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... I'd like to see how they calculated that, and their standard ... yet! Still, if it's a real trend, it could be alarming. ... change its pH, I guess! , A report issued by ... world's oceans. "If CO2 from human activities continues to rise, the ...
... from a study on a promising new vaccine against ... cervical pre-cancers and non-invasive cervical cancer, according to a ... Research's 4th Annual Frontiers in Cancer Prevention Research meeting ... phase III study, originally published in early October, confirmed ...
... Science University researchers have identified some of the key ... by multiple sclerosis (MS), complications of premature birth, and ... about why the nervous system fails to repair itself ... brain damage could be reversed. The research is published ...
Cached Biology News:Oceans turning to acid from rise in CO2 2Updated data on novel HPV vaccine confirms efficacy in large population 2Molecular Partners Required For Appropriate Neuronal Gene Repression 2Molecular Partners Required For Appropriate Neuronal Gene Repression 3Molecular Partners Required For Appropriate Neuronal Gene Repression 4
(Date:4/16/2015)... Miami, FL (PRWEB) April 16, 2015 ... therapy cap distribution and physician network in Europe ... marketing company has appointed Fernando Bermúdez, former Business ... Director. , An industry veteran, Mr. Bermúdez’s professional ... by 75% in Spain, while also penetrating the ...
(Date:4/16/2015)... 16, 2015  Schulman Associates IRB, Inc., the industry-leading ... a long-term lease on Laboratory Drive in the heart ... . The location will house review board and service ... quality reviews and customer service to clients. ... Schulman in the deal, while Capital Associates Management, LLC ...
(Date:4/16/2015)... 2015 According to the 2014 ... outside source was ranked first among the leading ... to lifting, pushing, pulling, holding, carrying, or throwing ... The David Round Company takes statistics like this ... hard to develop and design equipment that prevents ...
(Date:4/16/2015)... April 16, 2015 The Council ... the prestigious 2015 Borlaug CAST Communication Award goes ... at Tuskegee University in Alabama. Award nominees must ... public presentations; and/or the use of television, radio, ... three areas. As a specialist in the field ...
Breaking Biology Technology:Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2
... SyntheMed, Inc. (OTC,Bulletin Board: SYMD), a biomaterials ... drug delivery products and other,surgical implants, announced today ... 2008 MedTech conference being held in Washington, D.C. ... CEO of SyntheMed, is scheduled,to present on Wednesday, ...
... Keck Graduate Institute,(KGI) today announced that it will ... the latest developments in mammalian cell culture,from November ... explosive growth over the,last 25 years," said Matt ... and director of the Amgen Bioprocessing Center at ...
... results of implant operations., SAN CLEMENTE, Calif., ... to orthopedic surgeons being able to immediately gauge ... LifeModeler, Inc.,The company, a leading global provider of ... $400,000 of software and,services to InMotion Musculoskeletal Institute ...
Cached Biology Technology:SyntheMed To Present at the AdvaMed 2008 MedTech Conference 2KGI Offers Mammalian Cell Culture Program for Biotech Industry Professionals 2LifeModeler, Inc. Provides $400,000 Grant to InMotion Musculoskeletal Institute 2
Mouse monoclonal [164-12-2] to Ampicillin ( Abpromise for all tested applications)....
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
... Rabbit polyclonal to Kv4.2 Immunogen ... KLH, corresponding to amino acids 23-43 of ... Cross-reacts with Rat.Expected to cross-react with Human ... with immunogen), Rabbit (100% identity with immunogen) ...
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
Biology Products: