Navigation Links
H1N1 influenza adopted novel strategy to move from birds to humans
Date:12/8/2009

The 2009 H1N1 influenza virus used a new strategy to cross from birds into humans, a warning that it has more than one trick up its sleeve to jump the species barrier and become virulent.

In a report in this week's early online edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, researchers show that the H1N1, or swine flu, virus adopted a new mutation in one of its genes distinct from the mutations found in previous flu viruses, including those responsible for the Spanish influenza pandemic of 1918, the "Asian" flu pandemic in 1957 and the "Hong Kong" pandemic of 1968.

Previous influenza strains that crossed from birds into people had a specific point mutation in the bird virus's polymerase gene that allowed the protein to operate efficiently inside humans as well. The polymerase transcribes the virus's RNA, allowing the host to express viral genes, and also copies the viral genome, needed to make new viruses.

The 2009 H1N1 virus retains the bird version of the polymerase, but has a second mutation that seems to suppress the ability of human cells to prevent the bird polymerase from working.

"We were quite shocked when we looked at the swine flu virus, which was clearly replicating in people and other mammalian systems, yet had a polymerase that looked like it was derived from a bird virus, which should not function too well in a human cell type," said UC Berkeley post-doctoral fellow Andrew Mehle of the Department of Molecular and Cell Biology. "The other mutation within the polymerase seems to compensate and allow the enzyme to function."

The researchers also discovered another strategy one not yet adopted by any known flu virus by which influenza virus can increase its virulence even more. When a particular human subunit is substituted for one of the three protein subunits that make up the bird polymerase, the new combination makes the polymerase mo
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. St. Jude influenza survey uncovers key differences between bird flu and human flu
2. New field-deployable biosensor detects avian influenza virus in minutes instead of days
3. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
4. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
5. Getting wise to the influenza virus tricks
6. Tracking influenzas every movement
7. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
8. Genetic evidence for avian influenza movement from Asia to North America via wild birds
9. K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
10. SRI International to screen drugs that fight 2009 H1N1 influenza A
11. The challenges of avian influenza virus: Mechanism, epidemiology and control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... environmental scientists and engineers, led by Clemson University ... $5.25 million grant from the U.S. Department of ... make a direct positive impact on South Carolina ... of radioactive contaminants. , "Understanding the scientific and ... environmental aspects of nuclear technologies is imperative if ...
(Date:9/30/2014)... farm runoff in Hawaii is causing tumors in endangered ... study, published Tuesday in the peer-reviewed open-access journal ... up in algae that the turtles eat, promoting the ... internal organs. , Scientists at Duke University, the University ... (NOAA) conducted the study to better understand the causes ...
(Date:9/30/2014)... news release is available in German . ... in their behavioural response to risky situations such as ... for Ornithology now found in a long-term study on ... with both metabolic rate and ambient temperature. High metabolic ... behaviour, as in these scenarios birds were more likely ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2
... MAYWOOD, Ill. -- Most people know that too much sodium ... suggests that people trying to lower their blood pressure should ... effect to sodium. Researchers found that the ratio of ... cardiovascular disease than sodium or potassium alone. "There ...
... millions of genetic mutations has revealed four new DNA "hotspots" ... researchers led by the University of Michigan and including several ... in a just-published study. Appearing Jan. 25 in ... two other previously identified DNA sites, discovered by researchers at ...
... press release is available in French . ... study conducted by Universit de Montral researchers on ... treatment plant has revealed the presence of chemotherapy ... Bezafibrate (cholesterol reducing medication), enalapril (hypertension medication), methotrexate ...
Cached Biology News:Cutting salt isn't the only way to reduce blood pressure 2Researchers identify 4 genetic hotspots associated with psoriasis 2Researchers identify 4 genetic hotspots associated with psoriasis 3Hypertension and cholesterol medications present in water released into the St. Lawrence River 2
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
(Date:9/30/2014)... 2014 Rainbow Scientific, Inc. (RSI), ... recently opened an online store to add customer ... lines developed and manufactured by Biological Industries, Inc. ... Biological Industries’ Nutristem® serum-free, xeno-free reagents for human ... cell (hESC) culture. , The online store ...
(Date:9/30/2014)... 30, 2014 Back in the 1970’s, many ... feet. per employee, which included space for circulation and file ... Jeff Howell, partner at Nidea Corporate Real Estate / ... “By the year 2000, however, 250 square feet per ... number come down to 175 to 225 square feet, and ...
(Date:9/29/2014)... the start of the military conflicts in Iraq and ... United States with traumatic brain injury caused by exposure ... improvised explosive devices, or IEDs. Symptoms of traumatic brain ... headaches and nausea, to more severe impairments in memory ... of Defense has recognized the critical importance and complexity ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... SAN DIEGO, Sept. 24 Neurocrine Biosciences,Inc. (Nasdaq: ... the UBS Global Life Sciences Conference. The live presentation,will ... Eastern Time,(ET) /5:30 a.m. Pacific Time (PT). The presentation ... Company,s website at, http://www.neurocrine.com If you are ...
... Available Only through Professionals, New Immuno-Skin Complex(TM) Targets ... to Fight the Causes of Skin Aging, EL ... his,credit including professional esthetic treatments utilizing AHA,s, and the,category ... of Medicine at UCLA, founder of Murad Inc. and ...
... Inc., a leading developer of advanced medical devices ... J. Daniel,Cole as the company,s new Chairman of ... partner with Spray Venture Partners, a venture,capital firm ... brings twenty years of medical device operational experience,having ...
Cached Biology Technology:Murad Boosts Skin Immunity With the New Murad(R) Professional Line 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2