Navigation Links
H. pylori vaccine shows promise in mouse studies
Date:12/19/2013

Researchers from Southern Medical University in Guangdong, Guangzhou, China, have developed an oral vaccine against Helicobacter pylori, the bacteria responsible for peptic ulcers and some forms of gastric cancer, and have successfully tested it in mice. The research is published ahead of print in the journal Clinical and Vaccine Immunology.

The investigators constructed a live recombinant bacterial vaccine, expressing the H. pylori antigen, adhesin Hp0410, in the food-grade bacterium, Lactobacillus acidophilus. They then used it to orally vaccinate the mice.

The vaccine elicited specific anti-Hp0410 IgG antibodies in serum, and showed "a significant increase" in the level of protection against gastric Helicobacter infection, according to the report. When assayed, following challenge with H. pylori, immunized mice had significantly lower bacterial loads than non-immunized mice.

H. pylori is a class 1 human carcinogen, according to the World Health Organization. It causes gastritis, peptic ulcers, stomach cancer, and mucosa-associated lymphoid tissue lymphoma. Antibiotic therapy is complex, unsuccessful in some patients (particularly in developing countries) and relapse is common. A vaccine against H. pylori could circumvent these difficulties.

L. acidophilus, a bacterium which is common in yogurt cultures, has distinct advantages as an oral vaccine antigen delivery vehicle. It is safe and nontoxic. It resists the stomach's acidity and tolerates bile, all of which aids in enabling it to survive in the gastrointestinal (GI) tract for more than 72 hours. Additionally, it adheres to, and elicits an immune response from the GI tract mucosa.

The current first-line treatment option for H. pylori infection includes two antibiotics and a proton pump inhibitor, but is ineffective in roughly 20 percent of patients.

"The high cost of treatment,
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ironing out the link between H. pylori infection and gastric cancer
2. Special issue of Gut Microbes on Helicobacter pylori
3. Queens scientists seek vaccine for Pseudomonas infection
4. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
5. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
6. SFU HIV/AIDS vaccine research gets financial boost
7. Researchers identify Achilles heel of dengue virus, target for future vaccines
8. AAPS National Biotechnology Conference to highlight innovative vaccines
9. Army study: DNA vaccine and duck eggs protect against hantavirus disease
10. Sensitive test helps improve vaccine safety
11. Overweight? Theres a vaccine for that
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... One of Australia,s leading coral reef ecologists fears that ... for ecosystem survival that we once thought. , In ... the ARC Centre of Excellence for Coral Reef Studies ... the most important species within reef ecosystems. , In ... are vital jobs that keep the ecosystem safe and ...
(Date:9/15/2014)... professor in the Department of Science and Technology in ... Sciences at Virginia Tech, has won a 2014 National ... the prospects and problems of creating a global nuclear ... Fukushima I Nuclear Power Plant in March 2011 was ... nuclear emergencies, Schmid said. Three of the plant,s six ...
(Date:9/15/2014)... of the cheetah: The big predator is the fastest land ... just a few seconds. As it ramps up to top ... it reaches a full gallop. , Now MIT researchers have ... a robotic cheetah a sleek, four-legged assemblage of gears, ... its feline counterpart. The team recently took the robot for ...
Breaking Biology News(10 mins):Specialized species critical for reefs 2'Nuclear disasters don't respect national boundaries' 2Run, cheetah, run 2Run, cheetah, run 3
... of climate change on the microbial communities of two ... in Alaska, a University of Oklahoma research group has ... According to Jizhong Zhou, OU professor of botany ... Genomics, the results of these studies could potentially contribute ...
... WORCESTER, Mass. Researchers at the University of Massachusetts Medical ... which is implicated in 20 percent of inherited cases of ... a part in sporadic forms of the disease. Discovery of ... edition of Nature Neuroscience . While the SOD1 ...
... 18 October 2010, Singapore A total of 15 world ... in their respective fields at the 6th Decade of the ... 20 October 2010. Jointly organised by A*STAR,s Institute of ... (DRTech) and NUS,s Temasek Laboratories, it is the first such ...
Cached Biology News:UMMS researchers identify protein associated with sporadic ALS 2UMMS researchers identify protein associated with sporadic ALS 3Singapore hosts first 'Decade of the Mind' conference in Asia 2Singapore hosts first 'Decade of the Mind' conference in Asia 3
(Date:9/15/2014)... Hydro Dynamics, Inc. (HDI) of Rome, ... will be partnering with Proteaf Technologies (Proteaf) of ... implementing its Shock Wave Power Reactor (SPR) cavitation ... flow chemistry through process intensification has been widely ... for decades. The continuous chemistry has been ...
(Date:9/14/2014)... wide variety of ways, including by modifying the protein ... another form and perform no or even the "wrong" ... serious diseases such as Alzheimer,s, Parkinson,s or cystic fibrosis. ... "infect" other molecules of the same type and congregate ... can damage cells and tissues and make people ill. ...
(Date:9/13/2014)... Boehringer Laboratories Inc., with a forty year history ... successful broadcast of a live surgery by St. Luke’s ... FAMBS, and Maher El Chaar, MD, FACS, FAMBS, using ... This sleeve gastrectomy surgery was performed and broadcast live ... surgeons from around the world during the 5th International ...
(Date:9/12/2014)... 2014   Arthur Kay , the 23-year-old British ... Postcode Lottery Green Challenge 2014. The jury, chaired by ... USD) at the final in Amsterdam ... Kay,s company uses a patented process to upcycle ... and biomass pellets, used for powering buildings and transport ...
Breaking Biology Technology:Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2Measuring modified protein structures 2Measuring modified protein structures 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3
... is,strengthening its customer-focused biomarker services portfolio to,pharmaceutical, ... Xie will lead those efforts as Battelle,s ... a suite of biomarker services, including biomarker,discovery, ... clients,better define molecular mechanisms of diseases, toxicity, ...
... against management - with six million, votes revoked ... change rules, TORONTO, June 25 /PRNewswire/ - The ... be in court today and will seek a,declaration that ... Meeting,was illegally held and will request that a proper ...
... probiotic ingredient, GanedenBC30, to power new raisin bran probiotic muffins. ... ... Main Street Gourmet, one of the fastest growing manufacturers of gourmet ... muffin fortified with the high-survivability probiotic, GanedenBC30 (Bacillus coagulans ...
Cached Biology Technology:Battelle Selects Xie to Develop Biomarker Services 2Main Street Gourmet Launches New Probiotic Muffins 2Main Street Gourmet Launches New Probiotic Muffins 3
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... The new TC-412 thermal cycler, flexible on your ... is a high performance, high sample throughput instrument ... , Flexible block format: The truly user-friendly ... exchanged in a matter of seconds without the ...
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... which is based on a new flow-through technology, ... in situ hybridization of tissues on microscope slide ... study of gene expression, in situ hybridization (ISH) ... can be used to validate and confirm results ...
Biology Products: