Navigation Links
Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
Date:4/19/2012

Barcelona, Spain, Thursday 19 April 2012: Exciting new data presented today at the International Liver Congress 2012 shows the gut microbiota's causal role in the development of diabetes and non-alcoholic fatty liver disease (NAFLD), independent of obesity.(1) Though an early stage animal model, the French study highlights the possibility of preventing diabetes and NAFLD with gut microbiota transplantation the engrafting of new microbiota, usually through administering faecal material from a healthy donor into the colon of a diseased recipient.(2)

In the 16 week study, two groups of germ free mice received gut microbiota transplants; one set from donor mice displaying symptoms of insulin resistance and liver steatosis (responders), the other from normal mice (non responders). The donor mice were selected due to their response to being fed a high fat diet.

The germ free group that received microbiota from symptomatic mice (responder receivers - RR) showed higher levels of fat concentration in the liver as well as being insulin resistant. The germ free group that received microbiota from healthy mice (non-responder-receivers NRR) maintained normal glucose levels and sensitivity to insulin.

EASL Scientific Committee Member Dr Frank Lammert said: "The factors leading to Non-Alcoholic Fatty Liver Disease (NAFLD) are poorly understood, but it is known that NAFLD and Type 2 diabetes are characterised, respectively, by liver inflammation and metabolic disorders like insulin resistance."

"This study shows that different microbiota cause different metabolic responses in animals. By implanting microbiota from healthy mice, the study authors prevented the development of liver inflammation and insulin resistance, both indications of liver disease and diabetes. Thus, gut microbiota transplants could have a therapeutic role in the development of these diseases."

The RR mice also showed lower levels of microorganisms than usuall
'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-789-438-6428
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gut microbiota regulates bile acid metabolism
2. New book includes advances in the science and practice of transfusion and transplantation
3. REGiMMUNE presents enhanced efficacy data in preclinical transplantation models
4. Ovarian transplantation: New technique gives greatly improved results in this delicate operation
5. Ovarian transplantation: First baby is born after a new technique
6. Rare genetic disease successfully reversed using stem cell transplantation
7. Novel Parkinsons treatment strategy involves cell transplantation
8. Cell Transplantation reports consistent and successful islet isolations offer diabetes hope
9. Coral transplantation the simple and cheap solution to reef restoration
10. Ovarian transplantation restores fertility to old mice and also lengthens their lives
11. New cell transplantation journal launched
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... that a deficiency in serotonin a chemical messenger ... depression. In the journal ACS Chemical Neuroscience , ... serotonin in their brains (and thus should have been ... , Donald Kuhn and colleagues at the John ... School of Medicine note that depression poses a major ...
(Date:8/27/2014)... have largely succeeded in sidelining the use of ... its potential contributions to Americans, health conditions. But ... best way to assuage the nation,s insatiable sweet ... & Engineering News (C&EN), the weekly news ... the article, Stephen Ritter, a senior correspondent at ...
(Date:8/27/2014)... can be weaned later with no negative effects on ... at the University,s Roseworthy campus, published in the journal ... for pig producers. It allows improvements in piglet health ... usually start their oestrous cycles again during lactation, only ... says Ms Alice Weaver, PhD candidate with the School ...
Breaking Biology News(10 mins):New study throws into question long-held belief about depression 2Piglet weaning age no bar to litter frequency 2
... identify new anti-cancer, anti-infection response control mechanism , ... de recherches cliniques de Montréal (IRCM), and his ... the prestigious journal Nature Immunology of Nature Publishing ... treatment of cancers and infectious diseases. Current treatments ...
... to clone human embryos from eggs that have been ... easier for scientists to create embryonic stem cell lines ... and sperm for infertile couples, the 21st annual conference ... heard today (Monday 20 June). , Until now, scientists ...
... the structure of a crucial human immune system molecule ... an upcoming issue of the journal Science, the protein ... 23 leucine-rich repeats (LRRs). , The structure reveals details ... essential step toward fully understanding the critical role this ...
Cached Biology News:Major breakthrough in the treatment of cancers and infectious diseases 2Scientists succeed in cloning human embryos from eggs matured in the lab 2Scientists succeed in cloning human embryos from eggs matured in the lab 3Scripps research scientists solve structure of a critical innate immune system protein 2Scripps research scientists solve structure of a critical innate immune system protein 3Scripps research scientists solve structure of a critical innate immune system protein 4
(Date:8/27/2014)... 2014 WriteResult, LLC – a premier ... again shown superiority when it comes to meeting the ... ePRO portion of their most recent study closeout on-time ... chose WriteResult’s digital writing platform to collect Patient Reported ... to complete drew data from a number of assessments ...
(Date:8/26/2014)... An analysis by Replikins, Ltd. of Pubmed ... CoV virus strains has revealed extensive conservation and ... conservation and sharing of specific Replikin gene structures has ... as it did for the H5N1 influenza vaccine and ... been found to be effective (1,2). ...
(Date:8/26/2014)... 2014 An analysis by Replikins, Ltd. of ... virus strains in Pubmed, has revealed extensive conservation and ... conservation and sharing of specific Replikin gene structures has ... as it did for the H5N1 influenza vaccine and ... been found to be effective (1,2). ...
(Date:8/26/2014)... Vycom announced today that Modutek Corporation ... equipment, has selected its Flametec materials for a ... Beams (FRIB). This involved the creation of a ... Flametec PVC-C and Kytec PVDF material to clean superconducting ... linear accelerator (known as LINAC). , ...
Breaking Biology Technology:A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Modutek Selects Vycom’s Flametec Materials for Michigan State University’s Superconductor Equipment 2Modutek Selects Vycom’s Flametec Materials for Michigan State University’s Superconductor Equipment 3
... , , NEW YORK, Aug. 13 ... the second quarter ended June 30, 2009. , , Revenues ... in 2008. Net loss for the second quarter of 2009 was $103,330, ... Basic net loss per share for the second quarter of 2009 was $0.01, ...
... , , MANHATTAN, ... around the world hundreds of millions of dollars each year. , ... Hesse and Bob Rowland have been working to create new vaccines ... and its associated diseases continue to emerge around the world," Hesse ...
... FORT LAUDERDALE, Fla., Aug. 13 OmniComm Systems, Inc. ... capture (EDC) solutions for clinical trials, today announced that it ... Organization (CRO) to provide eClinical solutions for a pivotal Phase ... serve to establish the safety and efficacy of investigational new ...
Cached Biology Technology:Cadus Reports Second Quarter 2009 Results 2Cadus Reports Second Quarter 2009 Results 3Cadus Reports Second Quarter 2009 Results 4Cadus Reports Second Quarter 2009 Results 5K-State's Biosecurity Research Institute Gives Researchers the Tools Needed to Study Diseases That Cost Pig Producers Hundreds of Millions of Dollars Each Year 2K-State's Biosecurity Research Institute Gives Researchers the Tools Needed to Study Diseases That Cost Pig Producers Hundreds of Millions of Dollars Each Year 3Leading European Contract Research Organization Selects OmniComm to Provide eClinical Solutions for Important Phase III Study 2