Navigation Links
Gut microbiota regulates bile acid metabolism

A new study presented today at the International Liver Congress 2012 demonstrates that the gut microbiota has a profound systemic effect on bile acid metabolism.(1)

Bile acids are synthesised from cholesterol in the liver and further metabolised by the gut microbiota into secondary bile acids. The main function of bile acid is to promote processing of dietary fat. In addition, hepatic synthesis of bile acids is a major mechanism of cholesterol breakdown in the body. Farnesoid-x-receptor (FXR) is known to play a key role in the regulation of bile acid synthesis and homeostasis.

The authors propose that the gut microbiota modulates bile acid synthesis by changing the bile acid pool composition and, hence, reducing FXR inhibition in the small intestine.

The study found that germ-free mice (without any gut microbiota) had elevated muricholic bile acid levels, in particular TβMCA (tauroconjugated β-muricholic acid), while conventionally housed mice (with gut microbiota) had reduced levels of muricholic acids. TβMCA blocks the activation of FXR.

The results demonstrate the gut microbiota's suppression of biosynthetic genes in the liver cholesterol-7α-hydroxylase (CYP7A1) was consistent with increased FXR-dependent activation of FGF15 (ileal fibroblast growth factor-15) in the small intestine, due to reduced TβMCA mediated inhibition of FXR.

The gut microbiota performs unique digestive functions that cannot be performed by a germ-free intestinal tract. The cells constituting the microbial organ form metabolic and signalling networks with each other and their host.


Contact: Travis Taylor
European Association for the Study of the Liver

Page: 1

Related biology news :

1. Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
2. Montana State University researchers find gene that regulates molds resistance to drugs
3. Protein that regulates hormones critical to womens health found in pituitary
4. DREAM: 1 gene regulates pain, learning and memory
5. System that regulates blood pressure is amiss in some healthy, young blacks
6. Heart protein regulates blood vessel maintenance
7. Protein regulates movement of mitochondria in brain cells
8. Pitt team finds molecule that regulates heart size by using zebrafish screening model
9. STAT3 gene regulates cancer stem cells in brain cancer
10. Plant hormone regulates nectar production
11. Protein regulates enzyme linked to Alzheimers disease
Post Your Comments:
(Date:11/12/2015)... Nov. 12, 2015  A golden retriever that stayed ... dystrophy (DMD) has provided a new lead for treating ... the Broad Institute of MIT and Harvard and the ... . Cell, pinpoints a protective ... the disease,s effects. The Boston Children,s lab of ...
(Date:11/11/2015)... Minn. , Nov. 11, 2015   MedNet Solutions ... entire spectrum of clinical research, is pleased to announce that ... in Clinical Trials (PCT) event, to be held November ... be able to view live demonstrations of iMedNet ... and learn how iMedNet has been able to ...
(Date:11/9/2015)... , Nov. 09, 2015 ... the addition of the "Global Law ... their offering. --> ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( ) has ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... The ... newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent ... the last few years. Many AMA members have embraced this type of racing and ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... the remaining 11,000 post-share consolidation (or 1,100,000 pre-share ... "Series B Warrants") subject to the previously disclosed ... 23, 2015, which will result in the issuance ... to the issuance of such shares, there will ...
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh industrial processes, ... for in-line sensors can represent a weak spot where leaking process media is ... retractable sensor housings , which are designed to tolerate extreme process conditions. They ...
Breaking Biology Technology: