Navigation Links
Gut microbiota regulates bile acid metabolism
Date:4/19/2012

A new study presented today at the International Liver Congress 2012 demonstrates that the gut microbiota has a profound systemic effect on bile acid metabolism.(1)

Bile acids are synthesised from cholesterol in the liver and further metabolised by the gut microbiota into secondary bile acids. The main function of bile acid is to promote processing of dietary fat. In addition, hepatic synthesis of bile acids is a major mechanism of cholesterol breakdown in the body. Farnesoid-x-receptor (FXR) is known to play a key role in the regulation of bile acid synthesis and homeostasis.

The authors propose that the gut microbiota modulates bile acid synthesis by changing the bile acid pool composition and, hence, reducing FXR inhibition in the small intestine.

The study found that germ-free mice (without any gut microbiota) had elevated muricholic bile acid levels, in particular TβMCA (tauroconjugated β-muricholic acid), while conventionally housed mice (with gut microbiota) had reduced levels of muricholic acids. TβMCA blocks the activation of FXR.

The results demonstrate the gut microbiota's suppression of biosynthetic genes in the liver cholesterol-7α-hydroxylase (CYP7A1) was consistent with increased FXR-dependent activation of FGF15 (ileal fibroblast growth factor-15) in the small intestine, due to reduced TβMCA mediated inhibition of FXR.

The gut microbiota performs unique digestive functions that cannot be performed by a germ-free intestinal tract. The cells constituting the microbial organ form metabolic and signalling networks with each other and their host.


'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-789-438-6428
European Association for the Study of the Liver
Source:Eurekalert

Page: 1

Related biology news :

1. Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
2. Montana State University researchers find gene that regulates molds resistance to drugs
3. Protein that regulates hormones critical to womens health found in pituitary
4. DREAM: 1 gene regulates pain, learning and memory
5. System that regulates blood pressure is amiss in some healthy, young blacks
6. Heart protein regulates blood vessel maintenance
7. Protein regulates movement of mitochondria in brain cells
8. Pitt team finds molecule that regulates heart size by using zebrafish screening model
9. STAT3 gene regulates cancer stem cells in brain cancer
10. Plant hormone regulates nectar production
11. Protein regulates enzyme linked to Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:7/20/2017)... -- Delta (NYSE: DAL ) customers now can use fingerprints ... Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National ... Delta,s biometric boarding pass experience that launched ... into the boarding process to allow eligible Delta SkyMiles Members who are ...
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Rosalindâ„¢, the first-ever genomics analysis platform specifically designed for life science researchers ... honor of pioneering researcher Rosalind Franklin, who made a major contribution to ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... Palo Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... is set to take place on 7th and 8th June 2018 in San Francisco, ... and policy influencers as well as several distinguished CEOs, board directors and government officials ...
(Date:10/11/2017)... a leading provider of patient support solutions, has announced the ... which will launch this week. The VMS CNEs will address ... enhance the patient care experience by delivering peer-to-peer education programs ... to help women who have been diagnosed and are being ... ...
Breaking Biology Technology: