Navigation Links
Gut microbiota regulates bile acid metabolism
Date:4/19/2012

A new study presented today at the International Liver Congress 2012 demonstrates that the gut microbiota has a profound systemic effect on bile acid metabolism.(1)

Bile acids are synthesised from cholesterol in the liver and further metabolised by the gut microbiota into secondary bile acids. The main function of bile acid is to promote processing of dietary fat. In addition, hepatic synthesis of bile acids is a major mechanism of cholesterol breakdown in the body. Farnesoid-x-receptor (FXR) is known to play a key role in the regulation of bile acid synthesis and homeostasis.

The authors propose that the gut microbiota modulates bile acid synthesis by changing the bile acid pool composition and, hence, reducing FXR inhibition in the small intestine.

The study found that germ-free mice (without any gut microbiota) had elevated muricholic bile acid levels, in particular TβMCA (tauroconjugated β-muricholic acid), while conventionally housed mice (with gut microbiota) had reduced levels of muricholic acids. TβMCA blocks the activation of FXR.

The results demonstrate the gut microbiota's suppression of biosynthetic genes in the liver cholesterol-7α-hydroxylase (CYP7A1) was consistent with increased FXR-dependent activation of FGF15 (ileal fibroblast growth factor-15) in the small intestine, due to reduced TβMCA mediated inhibition of FXR.

The gut microbiota performs unique digestive functions that cannot be performed by a germ-free intestinal tract. The cells constituting the microbial organ form metabolic and signalling networks with each other and their host.


'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-789-438-6428
European Association for the Study of the Liver
Source:Eurekalert

Page: 1

Related biology news :

1. Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
2. Montana State University researchers find gene that regulates molds resistance to drugs
3. Protein that regulates hormones critical to womens health found in pituitary
4. DREAM: 1 gene regulates pain, learning and memory
5. System that regulates blood pressure is amiss in some healthy, young blacks
6. Heart protein regulates blood vessel maintenance
7. Protein regulates movement of mitochondria in brain cells
8. Pitt team finds molecule that regulates heart size by using zebrafish screening model
9. STAT3 gene regulates cancer stem cells in brain cancer
10. Plant hormone regulates nectar production
11. Protein regulates enzyme linked to Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... , April 17, 2015 ... security concerns, and technological advancement to drive biometric ... until 2020   According to ... Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market ... projected to register growth at CAGR of over ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NEC Security Competitive Profile 2015 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... California, Davis , who discovered a novel therapeutic target ... grant from the American Asthma , Foundation to investigate ... chronic disease affecting 300 million people worldwide, including 23 ... to evaluate whether the new field of , metabolomics ...
... process of domestication, humans would still be hunters and ... Fortunately, for all of us who do not relish ... and berries, early civilizations successfully cultivated many species of ... studies of the domestication of various species provide a ...
... Ore. Particulate air pollution during the 2008 Olympic ... the World Health Organization, was far worse than other ... than has been reported by Chinese environmental experts ... problem. The weather, in fact, turned out to ...
Cached Biology News:UC Davis grant zeroes in on novel asthma diagnosis and treatment 2UC Davis grant zeroes in on novel asthma diagnosis and treatment 3Domestication of Capsicum annuum chile pepper provides insights into crop origin and evolution 2Athletes, spectators faced unprecedented air pollution at 2008 Olympic Games 2Athletes, spectators faced unprecedented air pollution at 2008 Olympic Games 3
(Date:5/5/2015)... May 5, 2015 Psyche Systems Corporation and ... offers a first-of-its-kind platform that helps labs comply with ... results, transforms the way patients engage with these results, ... Health provides a HIPAA-compliant digital platform that gives ... and understand their lab results, and uniquely connects labs, ...
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, a ... heart failure and other chronic diseases, has engaged ... analysis designed to reflect the healthcare patterns of ... model will be used to characterize the impact ... have on those groups of patients and the ...
(Date:5/5/2015)... DIEGO , May 5, 2015  A group ... formation of the Coma Research Institute, a non-profit organization ... patients and families suffering from disorders of consciousness.  ... - http://photos.prnewswire.com/prnh/20150504/213779LOGO   ... disorder of consciousness, in which no voluntary actions can ...
(Date:5/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/x5gjj3/clinical ) ... Laboratory, Molecular Diagnostics and Genomic Testing Services Market ... Version" report to their offering. ... molecular diagnostics and pharmacogenics hold the promise of ... is moving out of the national and regional ...
Breaking Biology Technology:Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2
... The neurological system is the most fascinating and complicated ... many amazing tasks on a daily basis that it ... disorders have currently been identified and are being researched ... of Neurology, The Congress of Neurological Surgeons, and Chairman ...
... CARLSBAD, Calif., June 10, 2011 Life ... agreement for novel technology that enables synthetic biologists ... in engineered pathways and organisms. This technology, discovered ... in Germany, provides the ability to target ...
... energy-guru and favourite read of Bill Gates, Vaclav Smil,s gloomy ... Raynolds. "You need a hug," Raynolds said. ... took place on TVO,s The Agenda with Steve Paikan live ... is now archived at http://wgsi.org/events/tvos-agenda-steve-paikin-1 . THE ...
Cached Biology Technology:Mediaplanet Launches Campaign for Awareness of Neurological Issues 2Life Technologies Signs Exclusive License Agreement for TAL Effector Technology That Enables Synthetic Biologists to Precisely Control Gene Expression in Engineered Organisms 2Life Technologies Signs Exclusive License Agreement for TAL Effector Technology That Enables Synthetic Biologists to Precisely Control Gene Expression in Engineered Organisms 3Life Technologies Signs Exclusive License Agreement for TAL Effector Technology That Enables Synthetic Biologists to Precisely Control Gene Expression in Engineered Organisms 4High voltage! Power experts pull out all the stops at international energy meeting 2