Navigation Links
Gut microbes in healthy kids carry antibiotic resistance genes
Date:11/13/2013

Friendly microbes in the intestinal tracts (guts) of healthy American children have numerous antibiotic resistance genes, according to results of a pilot study by scientists at Washington University School of Medicine in St. Louis. The genes are cause for concern because they can be shared with harmful microbes, interfering with the effectiveness of antibiotics in ways that can contribute to serious illness and, in some cases, death.

"From birth to age 5, children receive more antibiotics than during any other five-year time span in their lives," said senior author Gautam Dantas, PhD, assistant professor of pathology and immunology. "Frequent exposure to antibiotics accelerates the spread of antibiotic resistance. Our research highlights how important it is to only use these drugs when they are truly needed."

The results appear Nov. 13 in PLOS ONE.

With funding from the Children's Discovery Institute, the International Center for Advanced Renewable Energy and Sustainability, the National Academies Keck Futures Initiative and the National Institutes of Health (NIH), the researchers analyzed fecal samples from 22 infants and children ranging in age from six months to 19 years. The samples were provided by Phillip Tarr, MD, the Melvin E. Carnahan Professor of Pediatrics at Washington University School of Medicine.

Despite the small sample size, the analysis identified 2,500 new antibiotic resistance genes, expanding the list of known antibiotic resistance genes by more than 30 percent.

"Microbes have been battling each other for millennia, regularly inventing new antibiotic synthesis genes to kill off rivals and new antibiotic resistance genes to defend themselves," Dantas said. "That microbial arms race is where this vast array of genetic resources comes from."

The scientists identified the new resistance genes by testing intestinal microbial DNA from the children against 18 antibiotics. The genes they
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Killer silk: Making silk fibers that kill anthrax and other microbes in minutes
2. Breast-fed babies gut microbes contribute to healthy immune systems
3. Honoring the fundamental role of microbes in the natural history of our planet
4. CU-Boulder-led team finds microbes in extreme environment on South American volcanoes
5. AGU: Unique microbes found in extreme environment
6. Waves of Berkeley Lab responders deploy omics to track Deepwater Horizon cleanup microbes
7. Gut microbes battle a common set of viruses shared by global populations
8. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
9. Stanford-Penn State scientists use microbes to make clean methane
10. Microbes make clean methane
11. Roots and microbes: Bringing a complex underground ecology into the lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
(Date:9/30/2014)... to tetrachloroethylene (PCE) in drinking water may increase ... to a new study led by a Boston ... study, published in the journal Environmental Health ... pregnancies among 1,766 women in Cape Cod, Ma., ... to the early 1980s by the installation of ...
(Date:9/30/2014)... reports positive results of a phase 1 clinical trial ... cancer marked by rearrangement of the gene ROS1. In ... cell lung cancer testing positive for ROS1 gene rearrangement, ... responses and 33 partial responses. Median progression-free survival ... its growth after being slowed by treatment is ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Contaminated water linked to pregnancy complications, BU study finds 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... Based on research that reveals new insight into mechanisms ... Mayo Clinic campus in Florida have a new understanding about ... elsewhere in the body, known as metastasis, is the process ... In the March 29 online issue of Nature Cell ...
... PHILADELPHIA - A team of biologists at the University of ... determined that a snail making its home in the northwest ... dramatic increase in the size of its shell during less ... and effectively change can occur. The study is published ...
... Polar 5 belongs to the Alfred Wegener Institute. It ... from the regional airport Bremerhaven on an Arctic measurement ... sea ice thickness and atmospheric variables in an area ... the centre of the project PAM-ARCMIP (Pan-Arctic Measurements and ...
Cached Biology News:Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells 2Penn biologists demonstrate that size matters... in snail shells 2Penn biologists demonstrate that size matters... in snail shells 3Research plane Polar 5 on Arctic campaign 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 The custom ... ISPE Boston Product Show 2014. The Boston Area Chapter ... the 23rd annual, day-long event for Wed., Oct. 1 ... promises to be the largest in ISPE Boston’s long ... upward of 3,000 attendees expected. , HOLLOWAY AMERICA ...
(Date:9/30/2014)... SoundConnect, an award ... dedicated to supporting business communication solutions, including business ... a carrier services specialist has joined ... connected and productive at all times. This growth ... businesses to cloud communications services. On a ...
(Date:9/30/2014)... On September 11, Pharma IQ conducted an ... of a session that he will lead on “Stem Cells” ... February 17-18, 2015 in London. In the interview posted ... Sherley to respond to several questions on the current state ... stem cell toxicity, and future trends in the use of ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Whitehouse ... been chosen by the Parenteral Drug Association (PDA) ... and 19, 2014) on container closure integrity testing. This ... integrity test methods and philosophies detailed in the recently ... Evaluation. The course will span container closure ...
Breaking Biology Technology:HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3SoundConnect Expands Carrier Services Division 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4
... Advise Agendia, AMSTERDAM, October 29 ... evolving field of cancer molecular diagnostics has ... Advisory Board. The newly,established Clinical and Scientific ... research and clinical expertise.,The advisors review early ...
... Oct. 29 /PRNewswire/ - Dalton Medicinal Chemistry ... Services, announces that it,has achieved a targeted ... Ingelheim (Canada) Ltd. The milestone achievement triggered,payment ... Chemistry Partners is utilizing their medicinal,chemistry expertise ...
... JOLLA, Calif., Oct. 29 Immunosyn,Corporation (OTC Bulletin ... Criner as the company,s Chief Financial and Accounting ... A.,McCain, Jr., has been appointed as the company,s ... as Corporate Secretary. "I believe that the ...
Cached Biology Technology:Agendia BV Appoints Clinical and Scientific Advisory Board 2Immunosyn Corporation Names G. David Criner as CFO 2
...
Immunogen: Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Src cDNA Expression Kit (wild type)...
...
Biology Products: