Navigation Links
Gut microbes affect MicroRNA response to bacterial infection
Date:12/9/2013

cules like miRNA - pieces of genetic material that are used to selectively regulate the creation of proteins. Here, the researchers used conventional mice and germ-free mice to address the question of whether - and how - the gut microbiota has an effect on the course of infection and on the production of these regulatory miRNA molecules.

When it comes to susceptibility to infection, the results were unequivocal: 24 hours after infection, germ-free mice harbored 10,000 times more L. monocytogenes bacteria in their small intestines and about 1,000 times more Listeria in their mesenteric lymph nodes than did the conventional mice.

At the level of miRNA, however, the differences were not immediately evident: the most highly expressed miRNAs were produced at the same levels in both types of mice and they didn't change much after infection. Nevertheless, the production of five miRNAs decreased after infection only in the conventional mice, indicating that the presence of the microbiota influences the level of miRNA expression.

"We found that even though the intestinal miRNA signature is globally stable, Listeria infection can affect the host miRNA response in a microbiota-dependent manner," says Cossart. When paralleled with the lower susceptibility of the conventional mice to infection, these down-regulated regulatory molecules present an intriguing result, write the authors.

Cossart says that this study and others indicate that miRNA may be involved in protecting the host from infection, but their precise role isn't yet clear. She notes that although this study was conducted in mice, miRNA and the protein coding gene targets they regulate may be very similar in mice and in humans. Cossart and her colleagues are planning to follow up on the work to try and figure out what impacts the changes in miRNA expression mean for the networks of protein-coding genes they regulate.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. At AGU: Shale sequestration, water for energy & soil microbes
2. Special issue of Gut Microbes on Helicobacter pylori
3. Gut microbes in healthy kids carry antibiotic resistance genes
4. Montana State team overcomes challenges, proves that microbes swim to hydrogen gas
5. UNH, UC Davis launch network to study environmental microbes
6. Network to study environmental microbes
7. Microbes in the gut help determine risk of tumors
8. Penn researchers identify molecular link between gut microbes and intestinal health
9. Gut microbes closely linked to proper immune function, other health issues
10. Toxic methylmercury-producing microbes more widespread than realized
11. Scientists discover thriving colonies of microbes in ocean plastisphere
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... selection for traits that are attractive to the opposite ... to mate, the tail of male peacocks being an ... Riverside have now found that sexual selection and "placentation" ... Describing the life histories of more than 150 species ... that species with placentas tend to have males that ...
(Date:7/9/2014)... nature,s ability to split the water molecule during ... artificial photosynthesis for clean, green and renewable energy ... scientists led by researchers with the Lawrence Berkeley ... Accelerator Laboratory. , Working at SLAC,s Linac ... x-ray laser, the researchers were able to take ...
(Date:7/9/2014)... traumatic injuries have identified an immune marker that ... hospital-acquired infection. The study, led by clinician-scientists at ... in the journal Shock , is part ... the clinical implementation of quick-turnaround immune function tests ... damage following critical illness or injury in pediatric ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3
... took place in Florence last week. It provided us with some ... Did life begin on Mars rather than on earth?, ... "Terror Bird", was probably a herbivore Goldschmidt2014 is ... June, 2014, so if you want to attend, put the dates ...
... estimate that there is a minimum of 320,000 viruses in ... a majority of them, they say, could provide information critical ... This undertaking would cost approximately $6.3 billion, or $1.4 billion ... fraction of the economic impact of a major pandemic like ...
... Candida albicans is a common fungus found living in, ... species causes no harm to humans unless it can breach ... or death. It is known as an opportunistic pathogen that ... New research, presented today at the Society for General Microbiology,s ...
Cached Biology News:First estimate of total viruses in mammals 2First estimate of total viruses in mammals 3First estimate of total viruses in mammals 4Research identifies how mouth cells resist Candida infection 2
(Date:1/14/2014)... MD (PRWEB) January 14, 2014 ... to developing innovative information technology solutions for patients, ... health care stakeholders, announced today the signing of ... US Food and Drug Administration (FDA). This ...
(Date:1/14/2014)... Washington, USA, and Cardiff, UK (PRWEB) January 13, 2014 ... photonics technology development leader with more than 20 years ... society for optics and photonics . Hainsey will serve ... are delighted to have Dr. Hainsey join SPIE as ...
(Date:1/14/2014)... 14, 2014 During the 1600’s through the ... “The Doctor’s Plague.” In this time period, doctors did not ... at times, to the death of vulnerable patients. In the ... that they may be unwittingly transmitting herpes viruses to their ...
(Date:1/14/2014)... 14, 2014 BioMedomics, Inc. , a ... diagnostic platforms and novel disease specific POC tests, announced today ... netting a total of $690,000. The investment is from private ... company. This group of private investors has significant successful experience ...
Breaking Biology Technology:Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3BioMedomics, Inc. Closes $690K Round of Financing 2
... just the expected crowd of educators is congregating at ... Conference that runs through Friday; as the technologies ... fields involved. In addition to K-12 and higher education ... and military organizations. , ,Distance Learning 2005 is addressing ...
... The Centers for Medicare and Medicaid Services plan to officially ... Vista within the next few weeks, according to news accounts ... ,CMS officials hope that providing the new program, known as ... records by private clinicians. , ,Vista, a software program used ...
... Ann Stunden, director of the Division of Information Technology ... 2005 award for information technology leadership from the national ... for "strong and ground-breaking leadership in the information technology ... ago." , ,A co-founder and executive director of ...
Cached Biology Technology:Education conference focusing on importance of integrating technology 2Education conference focusing on importance of integrating technology 3Education conference focusing on importance of integrating technology 4
... Cycler unit is an inexpensive personal or mini ... PCR process. Lightweight, with a small footprint, it ... including the researcher's desk. , The Gene Cycler ... do not have access to a large laboratory ...
... Select Immunophosphatase Secondary Detection System is intended ... Prediluted Primary Antibody reagents, which contain rat ... of antigens by light microscopy in paraffin-embedded ... System may also be used with other ...
... RNA stain is used to stain and ... agarose gels and does not interfere with ... nm transilluminator, the stain emits a red-orange ... film or with a CCD camera-based gel ...
... efficient interfacing with mass spectrometry. Improved ... demands for benefits like these have ... routine applications. Standard HPLC systems, however, ... to operate with smaller bore columns ...
Biology Products: