Navigation Links
Gum disease found to worsen infection in animal model of AIDS
Date:1/31/2013

Texas Biomed scientists in San Antonio have found that moderate gum disease in an animal model exposed to an AIDS- like virus had more viral variants causing infection and greater inflammation. Both of these features have potential negative implications in long term disease progression, including other kinds of infections, the researchers say in a new report.

The public health message from the study is that even mild inflammation in the mouth needs to be controlled because it can lead to more serious consequences, said Luis Giavedoni, Ph. D, a Texas Biomed virologist and first author of the study.

"This is important because moderate gum disease is present in more than 50 percent of the world population. It is known that severe gum disease leads to generalized inflammation and a number of other health complications, but the conditions that we created were moderate and they were mainly localized in the mouth," he added.

"After infection with the simian AIDS virus, the generalized acute inflammation induced by the virus was exacerbated in the animals with gingivitis, indicating that even mild localized inflammation can lead to a more severe systemic inflammation," he added.

The study, funded by the National Institutes of Health (NIH) and conducted at Texas Biomed's Southwest National Primate Research Center (SNPRC), appears in the February 2013 issue of the Journal of Virology. Collaborators included scientists at the Dental School at UT Health Science Center San Antonio and at Seattle Biomed in Washington State.

Giavedoni and his colleagues studied whether inflammation of the mouth would increase the susceptibility of the monkeys to becoming infected with the monkey AIDS virus. This was based on epidemiological evidence that shows that infection and inflammation of the genital mucosa increases the chances of becoming infected with HIV by the sexual route.

The scientists induced moderate gum inflammation in a group of monkeys, while a second group without gum inflammation served as a control. After exposing both groups of macaques to infectious SIV, a monkey virus similar to AIDS, in the mouth they did not observe differences in the rate of infection, indicating the moderate gum disease did not increase the chances of getting infected with the AIDS virus.

"However, we did observe that the animals that had gum inflammation and got infected had more viral variants causing infection and they also showed augmented systemic inflammation after infection; both of these findings may negatively affect the progression of the viral infection." Giavedoni said.


'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Parkinsons disease stopped in animal model
2. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
3. U of Alberta researcher steps closer to understand autoimmune diseases
4. Common North American frog identified as carrier of deadly amphibian disease
5. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
6. Genetic research develops tools for studying diseases, improving regenerative treatment
7. Researchers discover novel therapy for Crohns disease
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Low-calorie diet may be harmful for bowel disease patients
10. Key to immune system disease could lie inside the cheek
11. Cell therapy using patients own bone marrow may present option for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016 ... Police deploy Teleste,s video security solution to ensure the safety ... France during the major tournament Teleste, ... communications systems and services, announced today that its video security ... to back up public safety across the country. ...
(Date:6/2/2016)... June 2, 2016 Perimeter Surveillance ... Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... will generate revenues of $17.98 billion in 2016. ... Inc, a leader in software and hardware technologies for ...
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour ... from the Q1 wave of its quarterly wearables survey. ... receptivity to a program where they would receive discounts ... company. "We were surprised to see that ... LaColla , CEO of Troubadour Research, "primarily because there ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...  Sequenom, Inc. (NASDAQ: SQNM ), a ... the development of innovative products and services, announced today ... States denied its petition to review decisions ... U.S. Patent No. 6,258,540 (",540 Patent") are not patent ... Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... NC (PRWEB) , ... June 24, 2016 , ... Researchers ... the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are ... to read it now. , Diagnostic biomarkers are signposts in the blood, lung ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
Breaking Biology Technology: