Navigation Links
Gum disease found to worsen infection in animal model of AIDS
Date:1/31/2013

Texas Biomed scientists in San Antonio have found that moderate gum disease in an animal model exposed to an AIDS- like virus had more viral variants causing infection and greater inflammation. Both of these features have potential negative implications in long term disease progression, including other kinds of infections, the researchers say in a new report.

The public health message from the study is that even mild inflammation in the mouth needs to be controlled because it can lead to more serious consequences, said Luis Giavedoni, Ph. D, a Texas Biomed virologist and first author of the study.

"This is important because moderate gum disease is present in more than 50 percent of the world population. It is known that severe gum disease leads to generalized inflammation and a number of other health complications, but the conditions that we created were moderate and they were mainly localized in the mouth," he added.

"After infection with the simian AIDS virus, the generalized acute inflammation induced by the virus was exacerbated in the animals with gingivitis, indicating that even mild localized inflammation can lead to a more severe systemic inflammation," he added.

The study, funded by the National Institutes of Health (NIH) and conducted at Texas Biomed's Southwest National Primate Research Center (SNPRC), appears in the February 2013 issue of the Journal of Virology. Collaborators included scientists at the Dental School at UT Health Science Center San Antonio and at Seattle Biomed in Washington State.

Giavedoni and his colleagues studied whether inflammation of the mouth would increase the susceptibility of the monkeys to becoming infected with the monkey AIDS virus. This was based on epidemiological evidence that shows that infection and inflammation of the genital mucosa increases the chances of becoming infected with HIV by the sexual route.

The scientists induced moderate gum inflammation in a group of monkeys, while a second group without gum inflammation served as a control. After exposing both groups of macaques to infectious SIV, a monkey virus similar to AIDS, in the mouth they did not observe differences in the rate of infection, indicating the moderate gum disease did not increase the chances of getting infected with the AIDS virus.

"However, we did observe that the animals that had gum inflammation and got infected had more viral variants causing infection and they also showed augmented systemic inflammation after infection; both of these findings may negatively affect the progression of the viral infection." Giavedoni said.


'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Parkinsons disease stopped in animal model
2. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
3. U of Alberta researcher steps closer to understand autoimmune diseases
4. Common North American frog identified as carrier of deadly amphibian disease
5. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
6. Genetic research develops tools for studying diseases, improving regenerative treatment
7. Researchers discover novel therapy for Crohns disease
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Low-calorie diet may be harmful for bowel disease patients
10. Key to immune system disease could lie inside the cheek
11. Cell therapy using patients own bone marrow may present option for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2018)... , ... August 30, 2018 , ... ... residence times as a component of drug discovery programs. Longer-target engagement can result ... times are low throughput, require expensive instrumentation, or require the alteration of the ...
(Date:8/29/2018)... SAN JOSE, Calif. (PRWEB) , ... August 28, ... ... leader in cluster and cloud infrastructure automation software, announced that Data In Science ... , The HudsonAlpha Institute for Biotechnology is a non-profit genomics and ...
(Date:8/29/2018)... , ... August 29, 2018 ... ... validates first non-invasive technology to identify specific chromosomal abnormalities using morphological assessment ... Ovation Fertility and Australia-based Life Whisperer suggests that artificial ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ARBOR, Mich. (PRWEB) , ... September 06, 2018 , ... ... Directors. Dunbar has spent his career as an executive and leader of numerous biotech ... a private cell therapy and biologics company acquired by Thompson Street Capital in St. ...
(Date:8/29/2018)... ... , ... Cognition Corporation ®, a software company specializing in medical device ... , Ryan Ward, Director of Engineering at Zimmer Biomet, has been announced as ... manager with Zimmer Biomet for almost 15 years, Mr. Ward will focus his talk ...
(Date:8/26/2018)... YORBA LINDA, Calif. (PRWEB) , ... August 23, ... ... interactive virtual events for tech innovators, engineers, and scientists from around the world, ... and Immunology 2018 will cover an array of industries and disciplines, encompassing various ...
(Date:8/21/2018)... EAST HARTFORD, Conn. (PRWEB) , ... August 21, 2018 , ... ... Tech Top 40, an annual recognition of the fastest growing technology companies in Connecticut. ... event to be held on Wednesday, October 3, at the Connecticut Convention Center in ...
Breaking Biology Technology: