Navigation Links
Guidelines needed for creating germ cells in vitro, Cornell, JAX scientists state
Date:6/11/2014

Research aimed at developing germ cellsthe progenitors of eggs and spermin vitro should be held to especially rigorous scientific standards, a distinguished team of reproductive biologists declares in the journal Cell.

In the article, authors John Schimenti, Ph.D., of Cornell University and his Jackson Laboratory colleagues, Mary Ann Handel, Ph.D., and John Eppig, Ph.D., note that because "germ cells are the ultimate stem cells," laboratories are racing to develop these cells in vitro for assisted reproduction.

Yet the researchers claim that no one has yet conclusively demonstrated that meiosis, a critical step in the development of germ cells in mammals, can be replicated in vitro.

"Because the stakes are high when it comes to artificial reproductive technologies involving unprecedented germ cell manipulation, it is imperative that the scientific community applies the highest standards when conducting and evaluating research concerning in vitro gamete generation," they write.

The authors propose a list of benchmarkswhich they dub "gold standards"to substantiate successful in vitro development of germline cells in mouse models. Besides the key events that take place during spermatocyte and oocyte development, the ultimate test is whether a two-celled embryo created from germ cells developed in vitro will grow into a viable offspring when implanted in a host female.

Schimenti is director of Cornell's Center for Vertebrate Genomics and a professor of genetics in the departments of biomedical sciences and molecular biology and genetics. "These guidelines emanate from our combined many years of basic studies on meiosis," he says, "and are a reminder to the 'translational' community of scientists of the hurdles to leap, as well as of the potential of the research for further understanding of meiosis."

With his JAX colleagues Handel and Eppig, Schimenti established a "Reprogenomics" program that has generated the world's most extensive collection of mouse models of infertility. He is a fellow of the American Association for the Advancement of Science.

Eppig, a fellow of the National Academy of Sciences and former president of the Society for the Study of Reproduction, achieved the first complete development of mammalian oocytes in vitro and, in 1996, the birth of the first mammal derived from an in vitro-developed oocyte, a mouse dubbed "Eggbert." Eppig is on the editorial board of the Proceedings of the National Academy of Sciences; he and JAX Senior Research Scientist Handel are former co-editors of the journal Biology of Reproduction.


'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Related biology news :

1. Current guidelines underestimate US cervical cancer incidence and older womens risk
2. New patenting guidelines are needed for biotechnology
3. One size does not fit all: Dietary guidelines for choline may be insufficient
4. Nutrition guidelines needed for full-service restaurant chains
5. EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus
6. Colon cancer screening guidelines may miss 10 percent of colon cancers
7. Weatherization work guidelines launched
8. Medboxs Marijuana Dispensing System Assists Operators in Complying with Federal Governments New Canna-Business Guidelines
9. Feline behavior experts release guidelines to improve the welfare of cats
10. Committee on Publication Ethics launches ethical guidelines for peer reviewers
11. DNA sequences need quality time too - guidelines for quality control published
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), ... published by MarketsandMarkets, the market is expected to be worth USD 18.98 billion ... Continue Reading ... ...      (Logo: ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology ... object recognition technologies, today announced the release of ... (SDK), which provides improved facial recognition using up ... on a single computer. The new version uses ... improve accuracy, and it utilizes a Graphing Processing ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... 2017 , ... Vortex Biosciences , provider of circulating tumor cell (CTC) ... cells using Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. ... Carlo and Dr. Matthew Rettig at the University of California, Los Angeles. The publication ...
(Date:5/23/2017)... Diego, CA (PRWEB) , ... May 23, 2017 , ... ... matrix of polymeric molecules, can cause diverse pathologies ranging from food poisoning and catheter ... impact of biofilms is in the tens of billions of dollars per year, there ...
(Date:5/22/2017)... Boston, MA (PRWEB) , ... May 22, 2017 , ... ... evidence, has expanded to the East Coast. It has opened an office in downtown ... innovative therapies are finding it increasingly more important to generate evidence on the value ...
(Date:5/21/2017)... ... May 19, 2017 , ... ... conference of the American Association of Bioanalysts (AAB) and the College of Reproductive ... The conference reinforces AAB’s commitment to excellence in clinical laboratory services and regulations. ...
Breaking Biology Technology: