Navigation Links
Guidelines needed for creating germ cells in vitro, Cornell, JAX scientists state
Date:6/11/2014

Research aimed at developing germ cellsthe progenitors of eggs and spermin vitro should be held to especially rigorous scientific standards, a distinguished team of reproductive biologists declares in the journal Cell.

In the article, authors John Schimenti, Ph.D., of Cornell University and his Jackson Laboratory colleagues, Mary Ann Handel, Ph.D., and John Eppig, Ph.D., note that because "germ cells are the ultimate stem cells," laboratories are racing to develop these cells in vitro for assisted reproduction.

Yet the researchers claim that no one has yet conclusively demonstrated that meiosis, a critical step in the development of germ cells in mammals, can be replicated in vitro.

"Because the stakes are high when it comes to artificial reproductive technologies involving unprecedented germ cell manipulation, it is imperative that the scientific community applies the highest standards when conducting and evaluating research concerning in vitro gamete generation," they write.

The authors propose a list of benchmarkswhich they dub "gold standards"to substantiate successful in vitro development of germline cells in mouse models. Besides the key events that take place during spermatocyte and oocyte development, the ultimate test is whether a two-celled embryo created from germ cells developed in vitro will grow into a viable offspring when implanted in a host female.

Schimenti is director of Cornell's Center for Vertebrate Genomics and a professor of genetics in the departments of biomedical sciences and molecular biology and genetics. "These guidelines emanate from our combined many years of basic studies on meiosis," he says, "and are a reminder to the 'translational' community of scientists of the hurdles to leap, as well as of the potential of the research for further understanding of meiosis."

With his JAX colleagues Handel and Eppig, Schimenti established a "Reprogenomics" program that has generated the world's most extensive collection of mouse models of infertility. He is a fellow of the American Association for the Advancement of Science.

Eppig, a fellow of the National Academy of Sciences and former president of the Society for the Study of Reproduction, achieved the first complete development of mammalian oocytes in vitro and, in 1996, the birth of the first mammal derived from an in vitro-developed oocyte, a mouse dubbed "Eggbert." Eppig is on the editorial board of the Proceedings of the National Academy of Sciences; he and JAX Senior Research Scientist Handel are former co-editors of the journal Biology of Reproduction.


'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Related biology news :

1. Current guidelines underestimate US cervical cancer incidence and older womens risk
2. New patenting guidelines are needed for biotechnology
3. One size does not fit all: Dietary guidelines for choline may be insufficient
4. Nutrition guidelines needed for full-service restaurant chains
5. EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus
6. Colon cancer screening guidelines may miss 10 percent of colon cancers
7. Weatherization work guidelines launched
8. Medboxs Marijuana Dispensing System Assists Operators in Complying with Federal Governments New Canna-Business Guidelines
9. Feline behavior experts release guidelines to improve the welfare of cats
10. Committee on Publication Ethics launches ethical guidelines for peer reviewers
11. DNA sequences need quality time too - guidelines for quality control published
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... 2016 The rising popularity of mobility ... is stoking significant interest in keyless access systems. ... low energy (BLE), biometrics and near-field communication (NFC) ... of wireless technologies in the automotive industry. This ... access systems opens the market to specialist companies ...
(Date:12/16/2016)... 2016 Research and Markets has announced the ... Forecast to 2021" report to their offering. ... The biometric vehicle access system ... CAGR of 14.06% from 2016 to 2021. The market is estimated ... reach 854.8 Million by 2021. The growth of the biometric vehicle ...
(Date:12/15/2016)... 2016 ... Research and Markets has announced the addition of the ... The report forecasts the global military biometrics market to grow at ... report has been prepared based on an in-depth market analysis with inputs ... prospects over the coming years. The report also includes a discussion of ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... CALABASAS, Calif. , Jan. 19, 2017 /PRNewswire/ ... Mathias Schmidt , Ph.D., as chief executive ... board of directors. Dr. Schmidt brings to ArmaGen more ... on the research and development of biotherapeutics and ... biopharmaceutical executive with the diverse experience and skillset ...
(Date:1/19/2017)... ... January 19, 2017 , ... DaVita Clinical ... spectrum of drug and device development, and Prism Clinical Research , a ... today announced Verified Clinical Trials (VCT) has been selected by both ...
(Date:1/18/2017)... ... January 18, 2017 , ... Opal ... using USB or PCI Express, announced the ZEM5310 USB 3.0 FPGA Module, combining ... a compact business-card sized form factor suitable for prototyping, testing, and production-ready integration. ...
(Date:1/18/2017)... ... January 18, 2017 , ... Executive search firm Slone Partners ... commitment to the advancement of the clinical trials segment. Hosted in Miami, this ... trial planning and management. , As executive talent specialists in the industries ...
Breaking Biology Technology: