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'Guardian of the genome': Protein helps prevent damaged DNA in yeast
Date:7/31/2010

rthologues) to Mec1, other related proteins with similar biological pathways in humans. Also, mutations to the human genes that produce Mec1 and related proteins can lead to cancer predisposition and neurological disorders. At the same time, cancer cells employ their own similar replication repair system, so understanding the process may help researchers design interventions that interrupt replication of cancer DNA.

Recently, other researchers discovered that the human version of Mec1, called ATR, phosphorylates a protein that is the human counterpart to Slx4. The next step, Smolka said, will be to see if after phosphorylation the human Slx4 also anchors to the replication machinery to repair any damaged machinery or DNA.


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Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University
Source:Eurekalert

Page: 1 2

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