Navigation Links
Growth of new brain cells requires 'epigenetic' switch
Date:1/8/2009

New cells are born every day in the brain's hippocampus, but what controls this birth has remained a mystery. Reporting in the January 1 issue of Science, neuroscientists at the Johns Hopkins University School of Medicine have discovered that the birth of new cells, which depends on brain activity, also depends on a protein that is involved in changing epigenetic marks in the cell's genetic material.

"How is it that when you see someone you met ten years ago, you still recognize them? How do these transient events become long lasting in the brain, and what potential role does the birth of new neurons play in making these memories?" says Hongjun Song, Ph.D., an associate professor of neurology and member of the Johns Hopkins Institute of Cell Engineering's NeuroICE. "We really want to understand how daily life experiences trigger the birth and growth of new neurons, and make long-lasting changes in the brain."

The researchers reasoned that making long-term memories might require long-term changes in brain cells. And one type of cellular change that has long-lasting effects is so-called epigenetic change, which can alter a cell's DNA without changing its sequence but does change how and which genes are turned on or off. So they decided to look at the 40 to 50 genes known to be involved in epigenetics, and see if any of them are turned on in mouse brain cells that have been stimulated with electroconvulsive therapyshock treatment. "It's long been known that ECT induces neurogenesis in rodents and humans, so we used it as our test case to find what is triggered downstream to cause new cells to grow," says Song.

One gene turned on in response to ECT was Gadd45b, a gene previously implicated in immune system function and misregulated in brain conditions like autism. To confirm Gadd45b is turned up in response to brain activity, the researchers also examined mice experiencing a different activity. Exposure to new surroundings, the t
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Aquacultures growth seen as continuing
2. Lack of vitamin D causes weight gain and stunts growth in girls
3. Surface-level ozone pollution set to reduce tree growth 10 percent by 2100
4. Duke study pinpoints potential green collar job growth in US
5. Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age
6. Mayo researchers identify dangerous two-faced protein crucial to breast cancer spread and growth
7. The bonsai effect: Wounded plants make jasmonates, inhibiting cell division, stunting growth
8. Bare bones of crystal growth: Biomolecules enhance metal contents in calcite
9. Making flies sick reveals new role for growth factors in immunity
10. Study links nicotine with breast cancer growth and spread
11. Discovery of natural compounds that could slow blood vessel growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 30, 2015 Genisphere announced ... to help further develop Genisphere,s therapeutics capabilities and portfolio. ... having spent much of the last 25 years in ... Bioscience, and Johnson & Johnson. Tom started his career ... Biotech Corporate Finance. He graduated from Dartmouth College with ...
(Date:6/25/2015)... CITY , June 25, 2015  Imagine a ... steps toward a healthier, happier life. That,s exactly what ... designed to do. The cutting-edge, portable health program provides ... real-life solutions to help improve your lifestyle and nutrition. ... awards dinner and gala Wednesday night, USANA,s THA was ...
(Date:6/24/2015)... , June 24, 2015  Synaptics Inc. ... human interface solutions, today announced that Sharp has ... provide secure authentication for its latest flagship smartphone ... more than 200 million shipments of its fingerprint ... reinforces Synaptics, strength, scalability and leadership in the ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... Technology have developed a computer program that trains itself ... Fungi which range from yeast to mushrooms ... understanding the recently sequenced fungal genomes can help in ... help to identify potential targets for therapeutic intervention and ...
... out of a scrum herpes virus can cause a skin ... studied the spread of the disease among sumo wrestlers in Japan ... be even more pathogenic, according to an article published in the ... "Scrumpox", or herpes gladiatorum , is a skin infection ...
... has established a National Corrosion Center where researchers will ... that is estimated to cost $276 billion a year ... center, Rice is working closely with NACE International, an ... around the world who are involved in virtually every ...
Cached Biology News:Researchers develop new self-training gene prediction program for fungi 2Researchers develop new self-training gene prediction program for fungi 3Researchers develop new self-training gene prediction program for fungi 4Deadly rugby virus spreads in sumo wrestlers 2Rice University establishes National Corrosion Center 2
(Date:6/29/2015)...  MiMedx Group, Inc. (NASDAQ: MDXG ), the ... patent-protected processes to develop and market advanced products and ... Medicine, Ophthalmic and Dental sectors of healthcare, announced that ... been awarded the Lifetime Achievement Award in the EY ... The Entrepreneur Of The Year Program, now in ...
(Date:6/29/2015)... SOUTH SAN FRANCISCO, Calif. , June 29, 2015 ... a molecular diagnostics company pioneering the field of molecular ... the Bay Area News Group,s prestigious Top Workplaces list ... group selects Top Workplace winners based solely on an ... "We are humbled and honored that the degree to ...
(Date:6/26/2015)... , June 26, 2015   Aratana ... a pet therapeutics company focused on the ... products for companion animals, today announced positive ... of capromorelin (AT-002), the company,s innovative therapeutic ... a small molecule that mimics ghrelin, the ...
(Date:6/26/2015)... MUMBAI, India , June 26, 2015 ... a leading global IT services, consulting and business solutions ... Leader in Worldwide Life Sciences R&D Risk-Based Monitoring by ... MarketScape: Worldwide Life Science R&D Risk-Based Monitoring 2015 Vendor ... The report evaluated eight leading IT services vendors with ...
Breaking Biology Technology:EY Entrepreneur Of The Year Program Recognizes Pete Petit, The Chairman & CEO of MiMedx 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 2Aratana Therapeutics Announces Positive Pivotal Results for AT-002 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 5TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4
... businesses will receive funding for technology development projects ... Technology Assistance Grant program. , ,The TAG program ... Wisconsin high-tech companies to offset the cost of ... are: Automated Notification Systems, Inc. , Eau ...
... They can cost as much as buildings and there ... the right people are involved and excited, said presenters at ... , ,"User ownership is absolutely essential," said Peter Strombom, CIO ... the application, if they don't feel they're being heard, you're ...
... - The nightmare of managing liability in identity ... of WTN Media's Digital Healthcare Conference, and healthcare providers ... it would be. , ,Using a hypothetical case of ... Michael Best & Friedrich demonstrated how much trouble ...
Cached Biology Technology:Healthcare leaders tell how they rally stakeholders around IT 2Managing the nightmare of identity theft 2Managing the nightmare of identity theft 3Managing the nightmare of identity theft 4
... formulated specifically for Alkaline Phosphatase conjugates. ... activity for both the enzyme and the ... This product has been chemically engineered ... a longer shelf life, resistance to various ...
... for arraying proteins of interest with ... equipment. DiscoverLight Protein Array Kits allow ... cell lysate or antibody in a ... specially designed nitrocellulose membranes with a ...
... formulated specifically for Alkaline Phosphatase conjugates. ... activity for both the enzyme and the ... This product has been chemically engineered ... a longer shelf life, resistance to various ...
Request Info...
Biology Products: