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Growth hormone's link to starvation may be clue to increasing life span, researchers find
Date:6/27/2008

has been shown to increase life span in mice, Dr. Kliewer said.

"In addition, intermittent fasting which increases FGF21 concentrations also extends life span in mice. This raises the intriguing possibility that FGF21 might be a longevity factor," Dr. Kliewer said.

"This is something that we're beginning to test in the lab," he said. "But our genetically engineered mice have all the classic hallmarks of extended life span: growth hormone resistance, low concentrations of IGF-1, increased insulin sensitivity and small size."

FGF21 is already being tested in human clinical trials for treatment of obesity and diabetes in adults, but the new findings linking FGF21 to interference with growth hormone might indicate that caution is needed before using it in children or teens, Dr. Kliewer said.


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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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