Navigation Links
Growth hormone helps repair the zebrafish ear

Loud noise, especially repeated loud noise, is known to cause irreversible damage to the hair cells inside the cochlea and eventually lead to deafness. In mammals this is irreversible, however both birds and fish are able to re-grow the damaged hair cells and restore hearing. New research published in BioMed Central's open access journal BMC Neuroscience shows that growth hormone is involved in this regeneration in zebrafish.

Researchers from Western Kentucky University and the University of Louisville worked together to see which genes were switched on or off after acoustic trauma and found distinct patterns of gene expression. Two days after noise injury, inner ear cells were busy dividing to repair and replace the damaged hair cells. This repair was associated with an alteration in the regulation of 839 genes and many of the cellular pathways involved were the same as those involved in cancer. This included a massive 64 fold increase in the transcription of growth hormone.

MHC I ZE (a gene involved in regulating immune responses) is down-regulated. But, since a strong inflammatory response to tissue damage can interfere with wound healing, it is probably a good idea to locally inhibit the immune response while repairing injury. Four days after trauma, these levels had begun to return to normal.

Dr. Michael Smith commented, "Injecting growth hormone into zebrafish stimulated cell proliferation in their inner ears, especially cells of the utricle, a vestibular organ involved in balance. There are many homologs between zebrafish and human genes and we are beginning to work on the function of these genes within the ear. Understanding how fish are able to repair their hair cells may eventually help us to understand ear injury in people and provide treatments for hair cell loss."


Contact: Guy Melzack
BioMed Central

Page: 1

Related biology news :

1. Growth in the global carbon budget
2. Discovery of natural compounds that could slow blood vessel growth
3. Study links nicotine with breast cancer growth and spread
4. Making flies sick reveals new role for growth factors in immunity
5. Bare bones of crystal growth: Biomolecules enhance metal contents in calcite
6. The bonsai effect: Wounded plants make jasmonates, inhibiting cell division, stunting growth
7. Mayo researchers identify dangerous two-faced protein crucial to breast cancer spread and growth
8. Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age
9. Duke study pinpoints potential green collar job growth in US
10. Surface-level ozone pollution set to reduce tree growth 10 percent by 2100
11. Lack of vitamin D causes weight gain and stunts growth in girls
Post Your Comments:
(Date:10/4/2017)... Solutions, a global clinical research organization (CRO), announces the launch of ... 4, 2017. Shadow is designed to assist medical writers and biometrics ... the European Medicines Agency (EMA) in meeting the requirements for de-identifying ... ... ...
(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... Disappearing forests and ... lives of over 5.5 million people each year. Especially those living in larger cities ... Treepex - based in one of the most pollution-affected countries globally - decided to ...
(Date:10/10/2017)... Los Angeles, CA (PRWEB) , ... ... ... Pharmaceuticals, Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) ... all uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed ...
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population ... challenge of how to continue to feed a growing nation. At the same time, ...
Breaking Biology Technology: