Navigation Links
Growth factor predicts poor outcome in breast cancer
Date:8/29/2008

The response to insulin-like growth factor 1 (IGF-I) in breast cancer cells predicts an aggressive tumor that is less likely to respond to treatment, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of Clinical Oncology. The finding gives impetus to the movement to tailor cancer treatments to attributes of the various tumors.

"These findings come at a critical time," said Dr. Adrian Lee, associate professor in the Lester and Sue Smith Breast Center at BCM. "Our goal is to identify biomarkers that will help predict which patients will respond to therapy against insulin-like growth factor. Several inhibitors of the IGF pathway are in patient studies right now. There's a large movement to understand which patients will respond to these drugs. This is a step toward that goal"

In this study, Lee and his colleagues stimulated breast cancer cells with IGF-I in the laboratory and defined how more than 800 genes in the cells responded to the growth factor. They then examined samples of patient breast tumors with this "gene signature" and correlated the gene signatures with the fate of the patients.

"We have technology now to allow us to globally assess what IGF is doing in breast cancer at the whole gene expression level," said Lee. "This is one of the first studies to do that. We know that IGF is bad in cancer, but now we can globally understand it in a more comprehensive manner. It could lead to finding biomarkers for patients response" to breast cancer treatments.

"We found that IGF-I is a major regulator of cell growth and cell survival," said Lee. "It also regulates DNA repair."

This has major implications for anti-cancer treatments that seek to cause DNA damage and tumor cell death.

"If you have something regulating DNA repair, you want that turned off," said Lee.

They found that tumors in which IGF (insulin-like growth factor) affe
'/>"/>

Contact: Kimberlee K. Norton
kknorton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Heavy metal link to mutations, low growth and fertility among crustaceans in Sydney Harbor tributary
2. Hydrogels provide scaffolding for growth of bone cells
3. Zebra Technologies Enters Into Revolving Credit Agreement to Support Company Growth
4. Old growth giants limited by water-pulling ability
5. BIO-key(R) Reports Profitability on Strong Revenue Growth for Second Quarter 2008
6. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
7. BIO-key(R) Reports Profitability on Strong Revenue Growth for Second Quarter 2008
8. Embryo biopsy does not affect early growth and risk of congenital malformations in PGD/PGS babies
9. Growth hormones link to starvation may be clue to increasing life span, researchers find
10. Blue light used to harden tooth fillings stunts tumor growth
11. Scientists find potential protein biomarkers for growth hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 08, 2014 Research and Markets ... the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of ... rural banking and upgradation of the driver,s license ... the market. Besides the aforementioned projects, biometrics is ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin Test ... innovative test solutions for military, aerospace, and manufacturing ... of its successful TS-900 PXI semiconductor test ... features of high-end systems to customers at a ... compared to traditional ATE. "Our ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... announced the end of the Human Genome Project, the ... thymine, cytosine, and guanineis unique to homo sapien DNA. ... genes coded in the human genome, but as time ... genes are controlled. Now, Harvard Stem Cell Institute ...
... Societies for Experimental Biology (FASEB) is proud to announce the ... were unveiled on FASEB,s web site and will be ... main campus. "The competition provides a glimpse into the exciting ... Margaret K. Offermann, MD, PhD. "The winning images and videos ...
... at The University of Texas at San Antonio (UTSA) ... investing $200,000 in new research to develop a low-cost ... the next year, the researchers will optimize an inexpensive ... It will be tested on water samples from the ...
Cached Biology News:HSCI researchers extend human epigenomic map 2FASEB announces BioArt image and video competition winners 2UTSA, Southwest Research Institute to develop low-cost method to treat fracking water 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 According to Ross ... Island Affiliate of ITRA Global, the national office market continues ... recovery. This is evidenced by the third quarter’s surprising ... market. Low energy costs have held inflation down and ... negative is the housing market remaining soft. , This solid ...
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... their #HolidayInTheLab pictures for a chance to win pipette-themed ... those struggling to think of a holiday gift for ... Lab Contest provides the ideal holiday presents. The #HolidayInTheLab ... pictures of their chemistree, holiday sweaters, as well as ...
(Date:12/24/2014)... Dec. 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... on December 22, 2014, thereby completing the U.S. ... the acquisition of the Company by Merck KGaA, ... satisfies another condition to closing the transaction, which ...
(Date:12/22/2014)... Dec. 22, 2014   Synthetic Biologics, ... of pathogen-specific therapies for serious infections and ... microbiome, today announced positive topline safety and ... trial of SYN-004, the Company,s investigational oral ... Clostridium difficile (C. difficile) infection, antibiotic-associated ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5
... MILWAUKEE Merge eFilm , a Wisconsin-based ... announced the release of FUSION PACS version 1.2.7. ... additional image manipulation tools, image viewer plug-in and ... drive toward an electronic medical record makes provision ...
... transformation. Such a dramatic change has not ... brewing, automotive and agriculture industries were beginning to ... agriculture and manufacturing-based state economy to a knowledge ... finds itself competing in a global marketplace and ...
... sat down with Tom Still, the president of the ... tenets of the organization and initiatives Still and others ... Read Part One. , , Wisconsin ... Technology Council has encountered and what are your greatest ...
Cached Biology Technology:Educate, innovate and execute: Wisconsins model for success 2Educate, innovate and execute: Wisconsins model for success 3WTN exclusive interview with Tom Still, Wisconsin Technology Council - Part 2 2WTN exclusive interview with Tom Still, Wisconsin Technology Council - Part 2 3WTN exclusive interview with Tom Still, Wisconsin Technology Council - Part 2 4