Navigation Links
Growth factor predicts poor outcome in breast cancer
Date:8/29/2008

The response to insulin-like growth factor 1 (IGF-I) in breast cancer cells predicts an aggressive tumor that is less likely to respond to treatment, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of Clinical Oncology. The finding gives impetus to the movement to tailor cancer treatments to attributes of the various tumors.

"These findings come at a critical time," said Dr. Adrian Lee, associate professor in the Lester and Sue Smith Breast Center at BCM. "Our goal is to identify biomarkers that will help predict which patients will respond to therapy against insulin-like growth factor. Several inhibitors of the IGF pathway are in patient studies right now. There's a large movement to understand which patients will respond to these drugs. This is a step toward that goal"

In this study, Lee and his colleagues stimulated breast cancer cells with IGF-I in the laboratory and defined how more than 800 genes in the cells responded to the growth factor. They then examined samples of patient breast tumors with this "gene signature" and correlated the gene signatures with the fate of the patients.

"We have technology now to allow us to globally assess what IGF is doing in breast cancer at the whole gene expression level," said Lee. "This is one of the first studies to do that. We know that IGF is bad in cancer, but now we can globally understand it in a more comprehensive manner. It could lead to finding biomarkers for patients response" to breast cancer treatments.

"We found that IGF-I is a major regulator of cell growth and cell survival," said Lee. "It also regulates DNA repair."

This has major implications for anti-cancer treatments that seek to cause DNA damage and tumor cell death.

"If you have something regulating DNA repair, you want that turned off," said Lee.

They found that tumors in which IGF (insulin-like growth factor) affe
'/>"/>

Contact: Kimberlee K. Norton
kknorton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Heavy metal link to mutations, low growth and fertility among crustaceans in Sydney Harbor tributary
2. Hydrogels provide scaffolding for growth of bone cells
3. Zebra Technologies Enters Into Revolving Credit Agreement to Support Company Growth
4. Old growth giants limited by water-pulling ability
5. BIO-key(R) Reports Profitability on Strong Revenue Growth for Second Quarter 2008
6. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
7. BIO-key(R) Reports Profitability on Strong Revenue Growth for Second Quarter 2008
8. Embryo biopsy does not affect early growth and risk of congenital malformations in PGD/PGS babies
9. Growth hormones link to starvation may be clue to increasing life span, researchers find
10. Blue light used to harden tooth fillings stunts tumor growth
11. Scientists find potential protein biomarkers for growth hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... in the Amazon help create tinderbox conditions for ... widespread forest loss during drought years, according to ... forests in the Amazon could reach a "tipping ... lead to large-scale loss of trees, making recovery ... geography, Penn State. , "We documented one of ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
(Date:4/17/2014)... genetic information of DNA is used to manufacture ... different functions in living organisms. Messenger RNA (mRNA) ... by relating the genetic information of DNA to ... , By examining the different types and amounts ... a given time, researchers can determine which specific ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Methane climate change risk suggested by proof of redox cycling of humic substances 2Rapid and accurate mRNA detection in plant tissues 2
... ARBORResearchers at the University of Michigan,s School of Natural ... study of disparities in access to healthy food across ... study data in 18 small to mid-sized cities to ... term that defines easy access to safe and healthy ...
... one of the experts who are currently working in ... Change (IPCC) assessment report on climate change. The report ... response strategies in the area of climate change mitigation ... Sterner is one of 281 experts from 56 different ...
... factors responsible for symptoms such as headaches, gastro-intestinal disorders, ... unconsciousness and cardiac arrhythmia in severe cases. Histamine, one ... cause serious physical problems. Biogenic amines can be produced ... also ingested in larger quantities with food. They play ...
Cached Biology News:U-M researchers to study 'food security' across Michigan 2Development of measures to prevent wine indispositions 2
(Date:1/15/2014)... 15, 2014 ­ RedBrick Health , a fast-growing ... today announces that EmblemHealth , the ... is now providing the RedBrick Compass health assessment, combined ... all of its members. EmblemHealth is among the first ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... BURLINGAME, Calif. , Jan. 14, 2014 As pet owners ... no doubt many of them wrote: "Take better care of my ... and even designer clothes and top-brand carrying cases to take the ... Pet parents might also feel compelled to buy some pricey toys ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... , , , ... 28 Avid Bioservices, Inc., a leading provider of cGMP contract manufacturing ... strengthened its executive team with the appointments of Truc Le as chief ... These additions reflect Avid,s recent successes in expanding its customer base and ...
... , Strategic Examination and Consolidation of Services ... Aug. 27 Little uniformity exists in the structure or functions ... according to Clinical Trials Offices: What,s New in Research ... Centers (AAHC). Emerging centralized clinical trial offices (CTOs) are among ...
... , , , , BETHLEHEM, ... , (Logo: http://www.newscom.com/cgi-bin/prnh/200 8 1022 ... from two Lehigh Valley healthcare leaders, Good S h epherd ... nc. (B. Braun), which are combining their knowledge, expertise and innovative ...
Cached Biology Technology:Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 2Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 3Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 4Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 5Clinical Trials Offices Changing Academic Health Center Research Infrastructure 2Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community 2Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community 3Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community 4
Human Legumain Affinity Purified Polyclonal Ab...
Human beta IG-H3 MAb (Clone 348506) Keywords: BIGH3, betaIG-H3 Protein Family: Extracellular Matrix Molecules...
Human Cystatin F MAb (Clone 292103)...
Rat CNTF R alpha Affinity Purified Polyclonal Ab...
Biology Products: