Navigation Links
Growth-factor-containing nanoparticles accelerate healing of chronic wounds
Date:1/26/2011

Massachusetts General Hospital (MGH) investigators have developed a novel system for delivery of growth factors to chronic wounds such as pressure sores and diabetic foot ulcers. In their work published in the Jan. 18 Proceedings of the National Academy of Sciences, the team from the MGH Center for Engineering in Medicine (CEM) reports fabricating nanospheres containing keratinocyte growth factor (KGF), a protein known to play an important role in wound healing, fused with elastin-like peptides. When suspended in a fibrin gel, these nanoparticles improved the healing of deep skin wounds in diabetic mice.

"It is quite amazing how just one dose of the fusion protein was enough to induce significant tissue regeneration in two weeks" says the paper's lead author Piyush Koria, PhD, formerly a postdoctoral fellow at the MGH-CEM and now at the University of South Florida. "Previous reports have suggested that KGF can help heal chronic wounds. But in most studies the growth factor was applied to the surface of the wound, limiting its availability to deeper tissues and requiring repeat applications to produce any clinical benefit. Using large quantities of growth factor would make this therapy extremely expensive. Our work circumvents these limitations by more efficiently delivering KFG throughout the wound to stimulate tissue regeneration."

The authors describe developing a fusion protein from recombinant KGF and elastin-like-peptides, which are major constituents of skin and other connective tissues. Laboratory experiments showed that the fusion protein retained the wound-healing properties of both elastin and KGF and that it rapidly and efficiently self-assembled into nanoparticles in response to a simple increase in temperature. When applied to deep skin wounds in genetically diabetic mice, the nanoparticles accelerated healing by stimulating the formation of both surface epithelial tissue and thick fibrous connective tissue.

"This technology has great potential because the fusion protein can be easily manufactured at a relatively low cost, is easy to administer and does not disappear as readily as the growth factor alone," explains Martin Yarmush, MD, PhD, director of the MGH Center for Engineering in Medicine and senior author of the study. "The technology also provides a platform for delivery of any growth factor or combination of factors. One could imagine administering a mixture of nanoparticles, each with a different factor, or a single set of nanoparticles with a mixture of fusion proteins on each."


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related biology news :

1. With chemical modification, stable RNA nanoparticles go 3-D
2. Cinnamon can replace harmful chemicals used to create nanoparticles
3. Drugs encased in nanoparticles travel to tumors on the surface of immune-system cells
4. Probing the nanoparticle: Predicting how nanoparticles will react in the human body
5. How many nanoparticles heat the tumor?
6. NIST nanofluidic multi-tool separates and sizes nanoparticles
7. New catalyst of platinum nanoparticles could lead to conk-out free, stable fuel cells
8. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
9. Researchers use nanoparticles as destructive beacons to zap tumors
10. K-State researchers find gene-silencing nanoparticles may put end to pesky summer pest
11. Researchers use nanoparticles to shrink tumors in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
Breaking Biology Technology: