Navigation Links
Growth-factor-containing nanoparticles accelerate healing of chronic wounds
Date:1/26/2011

Massachusetts General Hospital (MGH) investigators have developed a novel system for delivery of growth factors to chronic wounds such as pressure sores and diabetic foot ulcers. In their work published in the Jan. 18 Proceedings of the National Academy of Sciences, the team from the MGH Center for Engineering in Medicine (CEM) reports fabricating nanospheres containing keratinocyte growth factor (KGF), a protein known to play an important role in wound healing, fused with elastin-like peptides. When suspended in a fibrin gel, these nanoparticles improved the healing of deep skin wounds in diabetic mice.

"It is quite amazing how just one dose of the fusion protein was enough to induce significant tissue regeneration in two weeks" says the paper's lead author Piyush Koria, PhD, formerly a postdoctoral fellow at the MGH-CEM and now at the University of South Florida. "Previous reports have suggested that KGF can help heal chronic wounds. But in most studies the growth factor was applied to the surface of the wound, limiting its availability to deeper tissues and requiring repeat applications to produce any clinical benefit. Using large quantities of growth factor would make this therapy extremely expensive. Our work circumvents these limitations by more efficiently delivering KFG throughout the wound to stimulate tissue regeneration."

The authors describe developing a fusion protein from recombinant KGF and elastin-like-peptides, which are major constituents of skin and other connective tissues. Laboratory experiments showed that the fusion protein retained the wound-healing properties of both elastin and KGF and that it rapidly and efficiently self-assembled into nanoparticles in response to a simple increase in temperature. When applied to deep skin wounds in genetically diabetic mice, the nanoparticles accelerated healing by stimulating the formation of both surface epithelial tissue and thick fibrous connective tissue.


'/>"/>
Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. With chemical modification, stable RNA nanoparticles go 3-D
2. Cinnamon can replace harmful chemicals used to create nanoparticles
3. Drugs encased in nanoparticles travel to tumors on the surface of immune-system cells
4. Probing the nanoparticle: Predicting how nanoparticles will react in the human body
5. How many nanoparticles heat the tumor?
6. NIST nanofluidic multi-tool separates and sizes nanoparticles
7. New catalyst of platinum nanoparticles could lead to conk-out free, stable fuel cells
8. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
9. Researchers use nanoparticles as destructive beacons to zap tumors
10. K-State researchers find gene-silencing nanoparticles may put end to pesky summer pest
11. Researchers use nanoparticles to shrink tumors in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... BOSTON and TELTOW, Germany ... the 2015 Siggraph Conference, SensoMotoric Instruments (SMI) ... augmented reality , based on Epson,s Moverio ... eye tracking platform. With this new solution, unprecedented quality ... multi-modal, hands-free interaction with context-sensitive displays. For the first ...
(Date:8/4/2015)... 2015 Research ... the addition of the "Digital Forensics ... Sub-Segment (Computer Forensics, Network Forensics, Mobile Device ... Vertical and Region - Global Forecast to ... By Component (Hardware, Software, and Service), ...
(Date:7/31/2015)... 2015 A 10 a. Conferência Internacional ... BGI de 22-25 de outubro de 2015, em ... está celebrando seu 10 o. aniversário este ano. Desde ... das reuniões mais influentes do mundo no ramo das ... e prazerosos. A ICG-10 se concentra ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... at the University of California, Riverside has received an education fellowship ... encourage more Hispanic students to take an interest in and perform ... professor in the Department of Botany and Plant Sciences ... has been selected to participate in the 2011 USDA E. ...
... BOSTON (April 29, 2011) A gene therapy approach ... in slowing the signs of age-related macular degeneration (AMD), ... at Tufts University School of Medicine. Led by senior ... first time that CD59 delivered by a gene therapy ...
... , , , , , ... , , ... Several fish can be heard in... , Click here for more information. ... , , , , , , ...
Cached Biology News:Fellowship to UC Riverside botanist encourages Hispanic students to take up research 2Fellowship to UC Riverside botanist encourages Hispanic students to take up research 3Gene therapy shows promise against age-related macular degeneration 2Jump in communication skills led to species explosion in electric fishes 2Jump in communication skills led to species explosion in electric fishes 3Jump in communication skills led to species explosion in electric fishes 4Jump in communication skills led to species explosion in electric fishes 5Jump in communication skills led to species explosion in electric fishes 6Jump in communication skills led to species explosion in electric fishes 7
(Date:8/27/2015)... ... August 27, 2015 , ... The Kansas City Animal ... and animal health companies to hear from animal health companies with the newest ... received licensing agreements or distribution contracts. This meeting is one of the ...
(Date:8/27/2015)... Aug. 27, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: ... of regenerative medicine, today announced that executives from the ... month of September.  , Pedro ... & Renshaw,s 17th Annual Global Investment Conference on Wednesday, ... St. Regis Hotel in New York City ...
(Date:8/27/2015)... , ... August 27, 2015 , ... ... weighing needs and expertly narrows down the product choices to a manageable shortlist ... pares down the list to models that fit best with the customer’s industry ...
(Date:8/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... the detection of foodborne pathogens, today announced that Paul ... Company Emerging Growth Conference on September 2 at 9:20am ... York Marriott Marquis. A live webcast ... relations section of Roka Bioscience,s website at http://rokabio.investorroom.com/ ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2METTLER TOLEDO Updates Online Scale Selection Tool 2
... CHAPEL HILL, N.C., Nov. 5 As ... market, considerable efforts,are placed on strategy and ... largely focus on revenue growth and little ... launch excellence, a recent study,was conducted by ...
... Assay Designs, Inc., a leading,provider of ... life science,and translational research markets, has announced ... The agreement enables Assay Designs to,distribute approximately ... their U.S. and Canadian customers. This major ...
... N.Y., Nov. 5 Misonix, Inc.,(Nasdaq: MSON ... device,technology, which in Europe is used for the ... conditions, has entered into a new, three,year, exclusive ... Rotterdam, The Netherlands, for the distribution of the,SonaStar(TM) ...
Cached Biology Technology:New Study Provides Key Findings for Biopharma Product Launch Evaluation 2Assay Designs(TM), Inc. Announces Agreement with Abnova Corp. of Taiwan 2Misonix Announces New Distribution Agreement for The Netherlands 2Misonix Announces New Distribution Agreement for The Netherlands 3
... is a bovine protein-free alternative to ... an aqueous solution that contains non-toxic ... (3-(N-Morpholino) propanesulfonic acid), pH 6.0 - ... 0.02% methylisothiazolone and 0.02% bromonitrodioxane as ...
These 96-well 0.2 ml thin-wall PCR plate caps are caps that are used to seal 96-well, 0.2 ml thin-wall PCR plates. Supplied as 300 caps....
... software with the DeCypher Engine accelerator cards to ... perform searches like these from your desktop: ... under 6 days Align BAC-sized queries ... HMM analysis to compare 100,000 sequences to PFAM ...
Mouse monoclonal antibody to FMN2 - formin 2...
Biology Products: