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Growing without cell division
Date:11/1/2011

e mathematically modeled the behavior of molecules known to control this special type of cell cycle and the progression to polyploidy. We then made certain predictions about how these molecules were regulated during the endocycle that we tested in fruit flies."

Duronio said the study demonstrated that genes turned on and off in a cyclical manner was important for cells to continue endocycling and become polyploid. "We showed that one particular perturbation, or mutation, of this mechanism blocked the ability of cells to do that."

The UNC researcher said further research will determine if the findings " take us one step closer to being able manipulate cells becoming polyploid. And that might be important for, say, liver regeneration or liver diseases, where it's thought that polyploidy in liver cells may be important for liver function, either for liver detoxification or other aspects of liver biology."


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Contact: Les Lang
llang@med.unc.eu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

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