Navigation Links
'Grow your own transplant' may be possible for men with type 1 diabetes
Date:12/12/2010

PHILADELPHIA Men with type 1 diabetes may be able to grow their own insulin-producing cells from their testicular tissue, say Georgetown University Medical Center (GUMC) researchers who presented their findings today at the American Society of Cell Biology 50th annual meeting in Philadelphia.

Their laboratory and animal study is a proof of principle that human spermatogonial stem cells (SSCs) extracted from testicular tissue can morph into insulin-secreting beta islet cells normally found in the pancreas. And the researchers say they accomplished this feat without use of any of the extra genes now employed in most labs to turn adult stem cells into a tissue of choice.

"No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know SSCs have the potential to do what we want them to do, and we know how to improve their yield," says the study's lead investigator, G. Ian Gallicano, Ph.D., an associate professor in the Department of Cell Biology and Director of the Transgenic Core Facility at GUMC.

Given continuing progress, Gallicano says his strategy could provide a unique solution to treatment of individuals with type 1 diabetes (juvenile onset diabetes). Several novel therapies have been tried for these patients, but each has drawbacks. Transplanting islet cells from deceased donors can result in rejection, plus few such donations are available. Researchers have also cured diabetes in mice using induced pluripotent stem (IPS) cells adult stem cells that have been reprogrammed with other genes to behave like embryonic stem cells but this technique can produce teratomas, or tumors, in transfected tissue, as well as problems stemming from the external genes used to create IPS cells, Gallicano says.

Instead of using IPS cells, the researchers turned to a readily available source of stem cells, the SSCs that are the early precursors to sperm cells. They retrieved these cells from dec
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UGA researchers identify key enzyme that regulates the early growth of breast cancer cells
2. Researchers grow Rett syndrome in a Petri dish
3. Nanoengineers aim to grow tissues with functional blood vessels
4. Microsensors offer first look at whether cell mass affects growth rate
5. Gene discovery suggests way to engineer fast-growing plants
6. This faster-growing E. coli strains a good thing
7. Common diabetes drug may halt growth of cysts in polycystic kidney disease
8. Growing sorghum for biofuel
9. Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero
10. Radically simple technique developed to grow conducting polymer thin films
11. Microfluidics-imaging platform detects cancer growth signaling in minute biopsy samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... OXFORD, Conn. , Apr. 27, 2015 ... "Company"), a biometric authentication company focused on the growing ... will commence shipping to pre-order customers the first week ... pre-orders through the month of May. ... is a significant milestone for the company as Wocket® ...
(Date:4/17/2015)... Canada , April 17, 2015 ... growing security concerns, and technological advancement to drive ... until 2020   According ... Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems ... is projected to register growth at CAGR of ...
(Date:4/10/2015)... , April 10, 2015 Research ... of the "Security Competitive Profiles - NEC" ... , NEC will continue to supply a ... the market, with a company focus on the development ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NEC Security Competitive Profile 2015 2
... To promote the health of at-risk teenagers in Newark and ... The Horizon Foundation for New Jersey. ... to teach middle and high school students about nutrition, physical ... carried out by the Consortium for Pre-College Education in Greater ...
... of Anatomists has chosen Springer to publish its official ... issue will be published at Springer in April 2009. ... Anatomical Science International focuses on the morphological ... cellular, histological and gross anatomical studies. In addition ...
... world, nitrogen compounds are released to the atmosphere ... These pollutants are deposited to ecosystems as precipitation, ... downwind of their release point. The Catskill Mountains ... pointthough they contain little in the way of ...
Cached Biology News:Anatomical Science International joins Springer's publishing program 2Tree species composition influences nitrogen loss from forests 2
(Date:5/1/2015)... , May 1, 2015 ... equities: Genetic Technologies Ltd (NASDAQ: GENE ), ... Fisher Scientific Inc. (NYSE: TMO ), Sequenom ... (NYSE: PKI ). Free research report on ... . On Thursday, April 30, 2015, the NASDAQ ...
(Date:5/1/2015)... and RESEARCH TRIANGLE PARK, N.C. , May ... announced today that Roger Jeffs , Ph.D., President and ... and update on the company,s business at the Deutsche Bank ... Boston, Massachusetts . The presentation will take ... Time, and can be accessed via a live webcast on ...
(Date:4/30/2015)... 2015   Tamir Biotechnology , a leading developer ... its Ebola antiviral therapy program. Clinical ... currently being evaluated and considered by a number of ... During the first quarter of 2015, the company participated ... The Evaluation of Potential Treatments and Vaccines For Ebola ...
(Date:4/30/2015)... Nitto Avecia, a leading biotechnology ... capacity and production capability to serve biotechnology pharmaceutical ... service fulfillment continues to drive Nitto Avecia to ... capacities. , In Fall 2014, Nitto ... equipment at its Milford, MA facility, which is ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2
... supercomputer relies on off-the-shelf chips, open-source OS , ,Chippewa ... (SGI) in more ways than one. , ,As the companys ... back door in the final days of its fiscal first ... latest flagship product, the Altix 3000 family of servers and ...
... Madison , ,MADISON, WI- The University of Wisconsin ... eWeek, a weekly magazine for information technology executives, to ... enterprise computing solutions. , ,The testing took place ... the University of Wisconsin-Extension Pyle Center. The testing criteria ...
... Tucked away in a basement at Menasha Advantage, ... center its staff affectionately calls The Skunkworks. There, a ... of Radio Frequency Identification technology, Menasha Advantage is building ... a supply chain to another. The Internet-based system will ...
Cached Biology Technology:SGI banking on Altix to pay the freight 2SGI banking on Altix to pay the freight 3Six Spam Fighters Face Off in Madison 2Six Spam Fighters Face Off in Madison 3Six Spam Fighters Face Off in Madison 4E-Commerce Skunkworks in Menhasa 2E-Commerce Skunkworks in Menhasa 3
... 75 x ... recommended for immunohistochemistry of paraffin-embedded sections, ... at one end, markings ... normal procedures, precleaned, ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Donor feline serum and plasma...
Request Info...
Biology Products: