Navigation Links
Groundbreaking discovery of the cellular origin of cervical cancer
Date:6/12/2012

A team of scientists from A*STAR's Institute of Medical Biology (IMB) and Genome Institute of Singapore (GIS) together with clinicians from Boston's Brigham and Women's Hospital (BWH) have identified a unique set of cells in the cervix that are the cause of human papillomaviruses (HPV) related cervical cancers. Significantly, the team also showed that these cells do not regenerate when excised. These findings have immense clinical implications in the diagnosis, prevention and treatment of cervical cancer. The study was published in the prestigious journal, Proceedings of the National Academy of Sciences (PNAS), this week.

Cervical cancer is the 7th most common female cancer in Singapore and about 200 cases are diagnosed every year. Infection with HPV is the most common cause or risk factor for cervical cancer. HPV infection causes pre-invasive cancer, termed CIN (Cervical Intraepithelial Neoplasia), which are pre-cancerous lesions that can progress and potentially become invasive cancer if left untreated.k

Dr Christopher P. Crum, Director of Women's and Perinatal Pathology in the Department of pathology at BWH, said, "It has been a decades-old mystery why cervical cancers caused by HPV arise only from a discrete region of the cervix, known as the 'squamocolumnar junction', despite the presence of the virus throughout the genital tract. The discovery of these cells finally resolves this mystery and will have wide-ranging impact from developing more meaningful animal models of early cervical carcinogenesis to clinical implications."

The team discovered that this discrete set of cells, located at the squamocolumnar junction of the cervix, uniquely express biomarkers that are seen in all forms of invasive c%rvical cancers linked to HPV. This means that the signature markers of this population of cells can provide a way of distinguishing potentially dangerous precancerous lesions from those with a benign prognosis.

Dr Wa
'/>"/>

Contact: Ong Siok Ming
ong_siok_ming@a-star.edu.sg
65-682-66254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Lawson recieves Grand Challenges Explorations grant for groundbreaking research
2. Astellas and DNDi to collaborate on new drug discovery research for the treatment of NTDs
3. New discovery provides insight on long-standing pregnancy mystery
4. Speeding up drug discovery with rapid 3-D mapping of proteins
5. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
6. A whale of a discovery: New sensory organ found in rorqual whales
7. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
8. Discovery of mechanisms predicting response to new treatments in colon cancer
9. DNA barcoding verified the discovery of a highly disconnected crane fly species
10. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
11. Discovery of plant proteins may boost agricultural yields and biofuel production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... consumption could be as good for your mental as ... conducted by the University of Warwick,s Medical School using ... by BMJ Open focused on mental wellbeing ... consistently associated with an individual,s fruit and vegetable consumption. ... five or more portions of fruit and vegetables a ...
(Date:9/23/2014)... including humans, have parasitic DNA fragments called "jumping genes" ... in the process. And that phenomenon can result in ... University of Rochester now report that the "jumping genes" ... a multi-function protein stops keeping them in check in ... a study published today in Nature Communications , ...
(Date:9/22/2014)... of cut grass in recent years has been identified ... research says the aroma also summons beneficial insects to ... the plant signals the environment via the emission of ... queue for parasitic wasps to come to the plant ... pest insect," said Dr. Michael Kolomiets, Texas A&M AgriLife ...
Breaking Biology News(10 mins):Eating five a day may keep the blues away 2A multi-function protein is key to stopping genomic parasites from 'jumping' 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 3
... found that infants who were fed formula enriched with ... months scored significantly better than a control group on ... three to six years. Specifically, the children ... rule-learning and inhibition between the ages of three to ...
... increased the number of fruits and vegetables eaten and ... children had two secret weapons, according to a University ... and other relatives involved because family togetherness is a ... school, target only the child, but we know that ...
... University of Colorado Cancer Center member recently published in ... that in young, female cancer survivors, quality of life ... 59 cancer survivors to 66 healthy controls and found ... anxiety than the general population. Of note, survivors reported ...
Cached Biology News:DHA-enriched formula in infancy linked to positive cognitive outcomes in childhood 2Latino families in study eat more fruits and veggies, drink less soda 2Latino families in study eat more fruits and veggies, drink less soda 3Perception of fertility affects quality of life in young, female cancer survivors 2
(Date:9/23/2014)... 23, 2014 Texas Fertility Center (TFC) ... South Austin, expanding a Central Texas footprint that includes ... The satellite office for the region’s most established practice ... the South Austin, Buda, Kyle and San Marcos communities. ... fertility treatment directly to individuals and couples living in ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 The ... a developer of cellular modems , platforms ... in the Startup category for the 2014 Tekne ... held at the Minneapolis Convention Center on Thursday, ... and individuals who have shown superior technology innovation ...
(Date:9/22/2014)... CLARA, Calif. , Sept. 22, 2014 ... leading source of health information, today released the findings ... novel insights regarding physician and patient perspectives on health ... Eric Topol , a leading authority in the fields ... Editor-in-Chief of Medscape and Chief Academic Officer of Scripps ...
(Date:9/22/2014)... circulating tumor cells (CTCs) in a mouse model of ... several groups of CTCs, including significant differences from the ... generate metastases. In their study reported in the ... from the Massachusetts General Hospital (MGH) Cancer Center identified ... factors that may prove to be targets for improved ...
Breaking Biology Technology:Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4Massachusetts General study reveals gene expression patterns in pancreatic CTCs 2Massachusetts General study reveals gene expression patterns in pancreatic CTCs 3
... freeze budget proposal? Legislative Republicans voted for it because they ... convinced the freeze was good policy and secretly hoped Doyle ... Democrats and Gov. Jim Doyles proposal to raise the state ... vote for such a populist bill if it reaches the ...
... , ,* * * * * * * * * ... DEMOmobile 2003, and the experience has only strengthened our belief that ... The energy from the 400-plus attendees and 37 demonstrating companies was ... connectivity -- both in our homes and our businesses -- has ...
... - Representatives of the Medical College of Wisconsin, UW-Medical ... on a Milwaukee business television show, Avante's Leaders in ... on WISN. , ,Dr. Jeffrey Smith, clinical assistant professor ... School was joined by Mike Klein, founder and ...
Cached Biology Technology:Doyle and the Legislature Have Much To Agree Upon When It Comes To The Economy 2Doyle and the Legislature Have Much To Agree Upon When It Comes To The Economy 3The News From DEMOmobile 2003 2The News From DEMOmobile 2003 3The Information Age of Healthcare - Leaders featured on local new economy show 2The Information Age of Healthcare - Leaders featured on local new economy show 3
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Anti-DDDDK-Tag (Enterokinase Cleavage Site), Agarose Conjugate Research Focus: tag Storage: 4C Shipping Temperature: 4C...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Rabbit polyclonal to SERHL ( Abpromise for all tested applications). entrezGeneID: 94009 SwissProtID: Q9H4I8...
Biology Products: