Navigation Links
Groundbreaking discovery may lead to stronger antibiotics
Date:10/1/2008

CHARLOTTESVILLE, Va., Oct. 1, 2008 The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world. A new breakthrough by University of Virginia researchers provides physicians and patients a potential new approach toward the creation of less resistant and more effective antibiotics.

"As bacteria become more resistant to our current classes of antibiotics, there also has been a general lack of new targets for developing novel antibiotics," says John H. Bushweller, Ph.D., who led a new study appearing in the September 26, 2008, issue of Molecular Cell. "This is a dangerous situation, but our discovery provides a starting point for a completely novel class of antibiotics, acting via a different mechanism."

What Dr. Bushweller, professor of molecular physiology and biological physics, and fellow researchers at the UVA Health System and Harvard Medical School have determined is the structure of a particular integral membrane enzyme, called DsbB one of the many proteins that reside in cell membranes. These so-called integral membrane proteins are important, because they account for roughly one-third of any genome in the human body and are the targets of more than half of all currently used drugs.

Until now, scientists have been unable to acquire much structural information about these types of proteins; yet determining a protein's structure is vital in order to understand how it functions and how it can potentially operate as a drug target.

The study led by Dr. Bushweller represents the first time scientists have cracked the code required to solve a certain class of membrane protein structure by using nuclear magnetic resonance (NMR) spectroscopy, the preeminent technique for determining the structure of organic compounds. This novel NMR approach now gives the scientific community a brand new platform for attempting to determine structure
'/>"/>

Contact: Sally Jones
sallyhjones@virginia.edu
434-924-9241
University of Virginia Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Groundbreaking Canada-US study proves link between emissions and mercury pollution in fish
2. Groundbreaking Canada-US study proves link between emissions and mercury pollution in fish
3. BGSU undergraduates to pilot groundbreaking genome project
4. Discovery may help defang viruses
5. Stomach stem cell discovery could bring cancer insights
6. Symposium marks 30th anniversary of discovery of third domain of life
7. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
8. Natural product discovery by Cleveland medical researchers blocks tissue destruction
9. Researchers discovery may lead to hypertension treatment
10. Yale discovery suggests protein may play a role in severe asthma
11. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... During the past few years, Virginia Tech,s Wu Feng ... Microsoft grant from the "Computing in the Cloud" program, ... a $6 million award from the Air Force on ... from NSF and the National Institutes of Health on ... wove together the "parallel computing" aspects from each grant, ...
(Date:8/20/2014)... by researchers at the University of Missouri School of ... life-threatening heart condition caused by muscular dystrophy. , ... Ph.D., the leading author of the study and assistant ... of Molecular Microbiology and Immunology. "This is just a ... a treatment for people with this devastating heart condition, ...
(Date:8/20/2014)... leaves, photosystem 1 (PS1) absorbs light and its ... carbon dioxide to biomass. Photovoltaic devices, mostly build ... but produce electricity. One approach for the development ... the semi-conductor with the isolated membrane protein complexes ... a highly stable PS1 from thermophilic cyanobacteria that ...
Breaking Biology News(10 mins):The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4Gene therapy protects mice from lethal heart condition, MU researchers find 2A semi-artificial leaf faster than 'natural' photosynthesis 2
... Inc. the US branch of Munich (Germany) based Genomatix ... with Pfizer Pharmaceuticals to provide Genomatix software and data ... tools licensed by Pfizer are designed to show how ... scientists will use the software and data content to ...
... Past Emergency Response , In a special session ... learned during past incidents involving emergency evacuations, including ... response (some involving radiation). Presenters use these lessons ... ("Assessment of Emergency Response Planning and Implementation in ...
... America (ESA) will present societal awards to eight distinguished ... Wisconsin on Monday, August 4, 2008. Eminent ... the University of Arizona is the recipient of this ... in recognition of an outstanding body of ecological work ...
Cached Biology News:Emergency response and nanotechnology 2Ecological Society of America announces 2008 award recipients 2Ecological Society of America announces 2008 award recipients 3Ecological Society of America announces 2008 award recipients 4
(Date:8/20/2014)... 20, 2014 Neurotrope, Inc. (OTCQB: NTRP) ... call to provide an update on Company activities. ... timeDial-in numbers:(888) 505-4369 (U.S. and Canada) or (719) ... www.neurotropebioscience.com , under "Investor Relations"The teleconference replay will ... September 2, 2014 at (888) 203-1112 (U.S. and ...
(Date:8/20/2014)... 2014 High performance computing (HPC) ... most complete climate and Earth system model to ... issues. , Eight national laboratories, including Lawrence ... Center for Atmospheric Research, four academic institutions and ... participating national laboratories include Argonne, Brookhaven, Lawrence Berkeley, ...
(Date:8/20/2014)... Group finds that the vascular access device market in ... and China (BRIC) was valued ... of the United States market that year. ... as a result of strong economic expansion, improving access to healthcare ... Resources Group,s coverage of the BRIC vascular access device market: ...
(Date:8/20/2014)... 20, 2014  PAREXEL International Corporation (NASDAQ: ... at the Baird Healthcare Conference in New York.  ... Officer, will be making a presentation on PAREXEL and ... Sept. 3, 2014. A live webcast of ... of PAREXEL,s website at www.PAREXEL.com in the ...
Breaking Biology Technology:Neurotrope To Host Conference Call 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3PAREXEL International To Present At Baird Healthcare Conference 2
... NEW YORK , May 10 /PRNewswire-Asia-FirstCall/ -- American Oriental,Bioengineering, Inc. ... improving health through the development, manufacture and,commercialization of a broad range of prescription ... ended March,31, 2010 . , , ... First Quarter 2010 Financial Performance , ...
... CHAMPAIGN, Ill. , May 7 iCyt, ... announced the introduction of their new flow cytometry products at ... Cytometry (ISAC), held in Seattle . ( http://www.isac-net.org/ ) ... the two companies since iCyt was acquired by Sony in ...
... TOKYO , May 7, 2010 ... March 31, 2010 . Net sales were 104.8 billion yen for ... the same period,last year, mainly due to a recovery in orders in the ... , , , ...
Cached Biology Technology:American Oriental Bioengineering Reports First Quarter 2010 Financial Results 2American Oriental Bioengineering Reports First Quarter 2010 Financial Results 3American Oriental Bioengineering Reports First Quarter 2010 Financial Results 4American Oriental Bioengineering Reports First Quarter 2010 Financial Results 5American Oriental Bioengineering Reports First Quarter 2010 Financial Results 6American Oriental Bioengineering Reports First Quarter 2010 Financial Results 7American Oriental Bioengineering Reports First Quarter 2010 Financial Results 8iCyt Unveils New Flow Cytometry Products in Collaboration with Sony at CYTO2010 2iCyt Unveils New Flow Cytometry Products in Collaboration with Sony at CYTO2010 3Hoya Announces Fourth Quarter and Full-Year Financial Results 2Hoya Announces Fourth Quarter and Full-Year Financial Results 3
... Ac-DEVD-CHO is an inhibitor ... The concentration of inhibitor ... activity must be determined ... Ten micromolar inhibitor is ...
Human RELT/TNFRSF19L MAb (Clone 238104)...
homeo box D3, mRNA...
Human TSLP MAb (Clone 258136)...
Biology Products: