Navigation Links
Groundbreaking discovery may lead to stronger antibiotics
Date:10/1/2008

CHARLOTTESVILLE, Va., Oct. 1, 2008 The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world. A new breakthrough by University of Virginia researchers provides physicians and patients a potential new approach toward the creation of less resistant and more effective antibiotics.

"As bacteria become more resistant to our current classes of antibiotics, there also has been a general lack of new targets for developing novel antibiotics," says John H. Bushweller, Ph.D., who led a new study appearing in the September 26, 2008, issue of Molecular Cell. "This is a dangerous situation, but our discovery provides a starting point for a completely novel class of antibiotics, acting via a different mechanism."

What Dr. Bushweller, professor of molecular physiology and biological physics, and fellow researchers at the UVA Health System and Harvard Medical School have determined is the structure of a particular integral membrane enzyme, called DsbB one of the many proteins that reside in cell membranes. These so-called integral membrane proteins are important, because they account for roughly one-third of any genome in the human body and are the targets of more than half of all currently used drugs.

Until now, scientists have been unable to acquire much structural information about these types of proteins; yet determining a protein's structure is vital in order to understand how it functions and how it can potentially operate as a drug target.

The study led by Dr. Bushweller represents the first time scientists have cracked the code required to solve a certain class of membrane protein structure by using nuclear magnetic resonance (NMR) spectroscopy, the preeminent technique for determining the structure of organic compounds. This novel NMR approach now gives the scientific community a brand new platform for attempting to determine structures of other important membrane proteins.

"What this means is that not only did we establish NMR spectroscopy as a potent tool for the characterization of the structure, dynamics and function of integral membrane proteins, but we also discovered that the DsbB enzyme is an exciting potential new target agent for the creation of novel antibiotics," says Dr. Bushweller. "This could give us the roadmap to an entirely new class of antibiotics."


'/>"/>

Contact: Sally Jones
sallyhjones@virginia.edu
434-924-9241
University of Virginia Health System
Source:Eurekalert

Related biology news :

1. Groundbreaking Canada-US study proves link between emissions and mercury pollution in fish
2. Groundbreaking Canada-US study proves link between emissions and mercury pollution in fish
3. BGSU undergraduates to pilot groundbreaking genome project
4. Discovery may help defang viruses
5. Stomach stem cell discovery could bring cancer insights
6. Symposium marks 30th anniversary of discovery of third domain of life
7. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
8. Natural product discovery by Cleveland medical researchers blocks tissue destruction
9. Researchers discovery may lead to hypertension treatment
10. Yale discovery suggests protein may play a role in severe asthma
11. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
(Date:3/11/2016)... Germany , March 11, 2016 http://www.apimages.com ... - Cross reference: Picture is available at AP Images ( http://www.apimages.com ... from DERMALOG will be used to produce the new refugee identity ... other biometric innovations, at CeBIT in Hanover ... scanner from DERMALOG will be used to produce the new refugee ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... May 27, 2016 , ... Weeks after hosting a carpal tunnel syndrome workshop ... hand surgeon and founder of the Fitzmaurice Hand Institute, has announced the addition of ... a state-of-the-art technology and only 1 of about 3 currently available in the United ...
(Date:5/26/2016)... LINDEN, Mich. , May 26, 2016  Agriculture ... Des Moines, Iowa is running ... in Lake Erie and coastal ... is key to preventing this widespread issue. ... Michigan,s Upper Peninsula, developed a new, easy ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... company, today announced several positive developments that position the Company for the future. ... of the transaction, Craig F. Kinghorn has been appointed Chairman of the Board, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Founder ... double board-certified in surgery and surgery of the hand by the National Board ... stranger to going above and beyond in his pursuit of providing the most ...
Breaking Biology Technology: