Navigation Links
Green tea extract interferes with the formation of amyloid plaques in Alzheimer's disease
Date:3/5/2013

ANN ARBORResearchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.

The aggregation of these proteins, called metal-associated amyloids, is associated with Alzheimer's disease and other neurodegenerative conditions.

A paper published recently in the Proceedings of the National Academy of Sciences explained how U-M Life Sciences Institute faculty member Mi Hee Lim and an interdisciplinary team of researchers used green tea extract to control the generation of metal-associated amyloid-β aggregates associated with Alzheimer's disease in the lab.

The specific molecule in green tea, ()-epigallocatechin-3-gallate, also known as EGCG, prevented aggregate formation and broke down existing aggregate structures in the proteins that contained metalsspecifically copper, iron and zinc.

"A lot of people are very excited about this molecule," said Lim, noting that the EGCG and other flavonoids in natural products have long been established as powerful antioxidants. "We used a multidisciplinary approach. This is the first example of structure-centric, multidisciplinary investigations by three principal investigators with three different areas of expertise."

The research team included chemists, biochemists and biophysicists.

While many researchers are investigating small molecules and metal-associated amyloids, most are looking from a limited perspective, said Lim, assistant professor of chemistry and research assistant professor at the Life Sciences Institute, where her lab is located and her research is conducted.

"But we believe you have to have a lot of approaches working together, because the brain is very complex," she said.

The PNAS paper was a starting point, Lim said, and her team's next step is to "tweak" the molecule and then test its ability to interfere with plaque formation in fruit flies.

"We want to modify them for the brain, specifically to interfere with the plaques associated with Alzheimer's," she said.

Lim plans to collaborate with Bing Ye, a neurobiologist in the LSI. Together, the researchers will test the new molecule's power to inhibit potential toxicity of aggregates containing proteins and metals in fruit flies.


'/>"/>

Contact: Laura J. Williams
laurajw@umich.edu
734-615-4862
University of Michigan
Source:Eurekalert

Related biology news :

1. New method for greenhouse gas predictions
2. Gene discovery reveals importance of eating your greens
3. Experts to calculate potential of Greenlandic mineral wealth
4. Colorado Marijuana Task Force Gives Green Light To "Pot Tourism"
5. What green algae are up to in the dark
6. Cities can reduce greenhouse gas emissions by 70 percent, says U of T researcher
7. New guide will allow electric utilities to develop Green Button Web tools
8. Aarhus University builds research station in North Greenland
9. In beef production, cow-calf phase contributes most greenhouse gases
10. Analysis of Greenland ice cores adds to historical record and provide glimpse into climates future
11. Toward reducing the greenhouse gas emissions of the Internet and telecommunications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
Breaking Biology News(10 mins):
(Date:6/16/2017)... Lexington, Massachusetts (PRWEB) , ... June 16, 2017 ... ... in medical device compliance and commercialization, has just announced two more sessions of ... of the series will focus on the world of online templates for design ...
(Date:6/16/2017)... CT (PRWEB) , ... June 16, 2017 , ... ... night’s Entrepreneur Innovation Awards (EIA), held at The LOFT at Chelsea Piers in Stamford. ... project ideas to a panel of judges for an opportunity to secure $10,000 awards ...
(Date:6/15/2017)... ... June 15, 2017 , ... Cybrexa Therapeutics, a ... round of financing in the amount of $6 million. An investment vehicle affiliated ... the round. , The Series B funding will enable Cybrexa to complete the ...
(Date:6/15/2017)... (PRWEB) , ... June 15, 2017 , ... ... Saranas, a promising new medical device startup. Dan Parsley, angelMD’s SVP of Corporate ... angelMD members, and this angelMD syndicate is part of Saranas’ recently announced $4 ...
Breaking Biology Technology: