Navigation Links
Green gel
Date:4/18/2008

This release is available in German.

Researchers at the University of California, Berkeley (USA) have now developed a new strategy for the formation of hybrid materials from synthetic polymers and proteins. They have thus been able to fuse the specific biological functions of proteins with the advantageous bulk and processing properties of plastics. Polymer-protein hybrid materials may be of use in the manufacture of sensors, nanomachine parts, or drug-delivery systems. As Aaron P. Esser-Kahn and Matthew B. Francis report in the journal Angewandte Chemie, they have successfully synthesized a green-fluorescing biodegradable gel that responds to changes in pH value and temperature.

Previous processes for the production of hybrid materials depended on very specific coupling techniques that could not be used for some protein side-chains. In contrast, the new method developed by the Berkeley researchers is broadly applicable because in principle it is suitable for any protein. The coupling occurs at both ends of the protein chainand these are the same for all proteins: one amino acid group and one carboxylic acid group. Initially, two parallel but mutually independent (orthogonal) reactions are used to activate the two ends of the chain. These are then attached to special chemical anchor points on the polymer. The proteins thus cross-link the individual polymer chains into a three-dimensional network, forming what is known as a hydrogel. A hydrogel is a solid, gelatinous mass consisting of water incorporated in a polymer network. A well-known example of a hydrogel is the soft contact lens.

Francis and Esser-Kahn chose to use a protein that fluoresces green to cross-link their polymer chains. Because the protein maintains its normal folding pattern even after attachment to the polymer, the fluorescence is also maintained: The entire gel fluoresces green.

This hybrid material has a special trait: the cross-linking of the polymer chains is achieved exclusively by means of the proteins. Because proteins can be attacked by proteases, enzymes that disintegrate proteins, these gels are biodegradable. The green fluorescence of the protein is pH-dependent. The gel correspondingly also reacts to changes in pH. It only fluoresces in the basic range; in a lightly acidic medium, the gel no longer fluoresces. Raising the temperature also elicits a response from the gel. The protein denatures at about 70 C, which quenches the fluorescence and causes the gel to shrink.


'/>"/>

Contact: Matthew B. Francis
francis@cchem.berkeley.edu
510-643-9915
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. New study shows greenback cutthroat trout involved in recovery effort misidentified
3. American Chemical Society calls green chemistry bill a smart step
4. Salmon garnish points the way to green electronics
5. Using green chemistry to deliver cutting-edge drugs
6. Green skies: Engineers work may reduce jet travels role in global warming
7. A greenhouse in order to study the impact of climate change on plants
8. Green leather is in this season
9. Study involving more than 100 scientists provides new insights on green algae
10. Green alga genome project catalogs carbon capture machinery
11. Green algae -- the nexus of plant/animal ancestry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/21/2016)... Columbia , June 21, 2016 ... to the new role of principal product architect ... named the director of customer development. Both will ... chief technical officer. The moves reflect NuData,s strategic ... in response to high customer demand and customer ...
(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in ... Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio ... practical tips, tools, and strategies for clinical researchers. , “The landscape of how ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... ... 2016 , ... In a new case report published today in STEM CELLS ... developed lymphedema after being treated for breast cancer benefitted from an injection of stem ... with this debilitating, frequent side effect of cancer treatment. , Lymphedema refers ...
Breaking Biology Technology: