Navigation Links
Grasshopper mice are numb to the pain of the bark scorpion sting
Date:10/24/2013

ered that the bark scorpion toxin acts as an analgesic by binding to sodium channels in the mouse pain neurons, and this blocks the neuron from firing a pain signal to the brain.

Pain neurons have a couple of different sodium channels, called 1.7 and 1.8, and research has shown that when toxins bind to 1.7 channels, the channels open, sodium flows in and the pain neuron fires.

By sequencing the genes for both the 1.7 and 1.8 sodium channels, the scientists discovered that channel 1.8 in the grasshopper mice has amino acids different from mammals that are sensitive to bark scorpion stings, such as house mice, rats and humans. They then found that the scorpion toxin binds to one of these amino acids to block the activation of channel 1.8 and thus inhibit the pain response.

"Incredibly, there is one amino acid substitution that can totally alter the behavior of the toxin and block the channel," said Zakon.

The riddle hasn't been completely solved just yet, though, Rowe said.

"We know the region of the channel where this is taking place and the amino acids involved," she said. "But there's something else that's playing a role, and that's what I'm focusing on next."

Some resistance to prey toxins in mammals has been found in other species. The mongoose, for example, is resistant to the cobra. And naked mole rats' eyes do not burn in pain when carbon dioxide builds up in their underground tunnels.

This study, however, is the first to find that an amino acid substitution in sodium channel 1.8 can have an analgesic effect.

Rowe said studies such as this could someday help researchers target these sodium channels for the development of analgesic medications for humans.


'/>"/>

Contact: Ashlee Rowe
roweashl@msu.edu
517-432-4468
University of Texas at Austin
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New scorpion discovery near metropolitan Tucson, Arizona
2. Clemson hosting scientists who study devastating diseases
3. Paper-based device could bring medical testing to remote locales
4. Neuron claws in the brain enable flies to distinguish 1 scent from another
5. New Brain Supplement Focus Boost Launches, Boosting Alertness, Memory and Focus
6. Finally mapped: The brain region that distinguishes bits from bounty
7. FPC Awarded new Smartphone DW From Existing Prominent Asian OEM Customer for Launch With Leading US Operator
8. Funding for animal testing alternative
9. First update in a century in testing drugs for elemental impurities
10. CCNY chemists devise new way to prepare molecules for drug testing
11. With early, obvious benefit of a targeted cancer drug, should expensive clinical testing continue?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grasshopper mice are numb to the pain of the bark scorpion sting
(Date:9/19/2014)... for the sake of fairness per se but in ... say Frans de Waal, PhD, and Sarah Brosnan, PhD, ... which is defined as a negative reaction to unequal ... , Their conclusion comes after the co-authors reviewed ... that it is the evolution of forestalling partner dissatisfaction ...
(Date:9/18/2014)... PULLMAN, Wash. - Washington State University researchers have developed ... sediment to power waste cleanup in rural areas. ... lead to an inexpensive and quick way to clean ... treatment plants while reducing pollution. , Professor Haluk ... College of Engineering and Architecture discuss the system in ...
(Date:9/18/2014)... 18, 2014 New research into the Crimean-Congo hemorrhagic ... severe hemorrhagic disease in humans similar to that caused ... CCHFV infection. This discovery has the potential to lead ... , The research, reported in a paper ... and conducted by scientists at the Texas Biomedical Research ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3Researchers develop unique waste cleanup for rural areas 2Research milestone in CCHF virus could help identify new treatments 2
... fuel sources are lighting a fire under research to turn ... Bill 20, signed this week by Gov. Rick Perry, compliments ... used. The new law requires more renewable energy to be ... consumer energy needs and agriculture industry trends with the legislation ...
... some day be defeated by a single treatment, according ... University of Georgia's College of Veterinary Medicine. , Their ... and Marburg and includes investigators from Vanderbilt University Medical ... The study is being funded by a grant from ...
... Berkeley, has found that damage to a cell's DNA sets ... of a marker recognized by the body's immune system. , ... advanced online issue of Nature, shed light on a long-standing ... are able to attack tumors - can differentiate cells that ...
Cached Biology News:Researchers find ways to turn manure into power 2Researchers find ways to turn manure into power 3Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases 2New study finds how cells with damaged DNA alert the immune system 2New study finds how cells with damaged DNA alert the immune system 3
(Date:9/19/2014)... September 18, 2014 Scientists at NYU Langone Medical ... the efficiency of the process for turning adult cells ... compounds, including vitamin C. Using the new technique in ... obtained from adult skin cells by more than 20-fold ... is efficient and reliable, and thus should generally accelerate ...
(Date:9/19/2014)... California (PRWEB) September 19, 2014 ... and its potential to revolutionize the world has ... multinational corporations and small start-ups. The early years ... research projects largely due to the high risks ... Government budgets earmarked for this evolving technology have ...
(Date:9/19/2014)... , September 19, 2014 ... technology, development of emerging drug systems and advanced Laboratory ... Dickinson and Company (NYSE: BDX ), Thermo ... Biosciences Inc. (NASDAQ: RGDO ), Sangamo Biosciences ... (NASDAQ: HOLX) Pressure BioSciences, Inc. (OTCQB: PBIO) ...
(Date:9/19/2014)... -- Pfenex Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology ... to manufacture proteins including biosimilar therapeutics, today announced that ... Annual NewsMakers in the Biotech Industry conference in ... chief executive officer of Pfenex, will provide an overview ... Friday, September 26, 2014 at 10:00 a.m. EDT/7:00 a.m. ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Pfenex to Present at Upcoming Industry Conference on September 26 2
... ARAY ), a global leader in ... official journal of the Congress of Neurological,Surgeons, has ... , The supplement, titled ... different countries, focused on brain and spine,treatment using ...
... Inc. (ERT), (Nasdaq: ERES ), ... to provide integrated Cardiac Safety and Ambulatory ... to clinical trial sponsors and managers worldwide.eResearchTechnology ... (ECG), eClinical technology, ePRO, and other services ...
... Cell Technologies, Inc., a leader in adult stem cell production, announced ... Dr. Bayer will be responsible for developing pre-clinical and clinical ... trials using Stemedica products. , ... San Diego, CA ...
Cached Biology Technology:Neurosurgery Journal Issues Supplement Dedicated to CyberKnife Radiosurgery Experience 2Neurosurgery Journal Issues Supplement Dedicated to CyberKnife Radiosurgery Experience 3Neurosurgery Journal Issues Supplement Dedicated to CyberKnife Radiosurgery Experience 4ERT (eResearchTechnology, Inc.) and Integrium, LLC Form Alliance to Deliver Integrated Cardiac Safety and Ambulatory Blood Pressure Monitoring Services 2ERT (eResearchTechnology, Inc.) and Integrium, LLC Form Alliance to Deliver Integrated Cardiac Safety and Ambulatory Blood Pressure Monitoring Services 3ERT (eResearchTechnology, Inc.) and Integrium, LLC Form Alliance to Deliver Integrated Cardiac Safety and Ambulatory Blood Pressure Monitoring Services 4Stemedica Announces the Appointment of Dr. Michael Bayer as Director, Medical Services 2Stemedica Announces the Appointment of Dr. Michael Bayer as Director, Medical Services 3
... Polymerase I Large (Klenow) Fragment, Exonuclease Minus, ... both the 5´→3´ and the 3´→5´ exonuclease ... Polymerase I (1,2). It is used for ... displacement amplification (5). Klenow Fragment, Exonuclease Minus, ...
Goat polyclonal to Duffy / FY / DARC...
... centrifuge offers both high-speed and high-volume ... of rotor options, making it ideal for ... Maximum Versatility , High-speed (up to ... or high-volume (4 x 250mL) swinging bucket ...
... fully licensed, high throughput, water bath thermal cycler ... 24 microplates. This equates to 9,216 reactions per ... robotic arm rapidly transfers a basket of plates ... times that are considerably faster than those of ...
Biology Products: