Navigation Links
Grasshopper mice are numb to the pain of the bark scorpion sting
Date:10/24/2013

ered that the bark scorpion toxin acts as an analgesic by binding to sodium channels in the mouse pain neurons, and this blocks the neuron from firing a pain signal to the brain.

Pain neurons have a couple of different sodium channels, called 1.7 and 1.8, and research has shown that when toxins bind to 1.7 channels, the channels open, sodium flows in and the pain neuron fires.

By sequencing the genes for both the 1.7 and 1.8 sodium channels, the scientists discovered that channel 1.8 in the grasshopper mice has amino acids different from mammals that are sensitive to bark scorpion stings, such as house mice, rats and humans. They then found that the scorpion toxin binds to one of these amino acids to block the activation of channel 1.8 and thus inhibit the pain response.

"Incredibly, there is one amino acid substitution that can totally alter the behavior of the toxin and block the channel," said Zakon.

The riddle hasn't been completely solved just yet, though, Rowe said.

"We know the region of the channel where this is taking place and the amino acids involved," she said. "But there's something else that's playing a role, and that's what I'm focusing on next."

Some resistance to prey toxins in mammals has been found in other species. The mongoose, for example, is resistant to the cobra. And naked mole rats' eyes do not burn in pain when carbon dioxide builds up in their underground tunnels.

This study, however, is the first to find that an amino acid substitution in sodium channel 1.8 can have an analgesic effect.

Rowe said studies such as this could someday help researchers target these sodium channels for the development of analgesic medications for humans.


'/>"/>

Contact: Ashlee Rowe
roweashl@msu.edu
517-432-4468
University of Texas at Austin
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New scorpion discovery near metropolitan Tucson, Arizona
2. Clemson hosting scientists who study devastating diseases
3. Paper-based device could bring medical testing to remote locales
4. Neuron claws in the brain enable flies to distinguish 1 scent from another
5. New Brain Supplement Focus Boost Launches, Boosting Alertness, Memory and Focus
6. Finally mapped: The brain region that distinguishes bits from bounty
7. FPC Awarded new Smartphone DW From Existing Prominent Asian OEM Customer for Launch With Leading US Operator
8. Funding for animal testing alternative
9. First update in a century in testing drugs for elemental impurities
10. CCNY chemists devise new way to prepare molecules for drug testing
11. With early, obvious benefit of a targeted cancer drug, should expensive clinical testing continue?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grasshopper mice are numb to the pain of the bark scorpion sting
(Date:6/16/2015)... /CNW Telbec/ - handyem Inc. and FlowMetric Diagnostics ... of handyem,s HPC-150 portable flow cytometer within FlowMetric ... unprecedented model of mobile laboratory platform is presented ... Pennsylvania Convention Center, ... to 18 th 2015.  By virtue of ...
(Date:6/15/2015)... June 15, 2015 A new report ... reveals the majority of US consumers using mobile banking applications ... such as fingerprint and voiceprint, instead of having to prove ... to Telstra,s " Mobile Identity   -   The Fusion ... with smartphones now the primary channel used by Gen X ...
(Date:6/9/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... will be providing demonstrations of its iMedNet ... Information Association (DIA) Annual Meeting in Washington ... include previews of many exciting new enhancements that will ... 2015 Feature 1 Release. MedNet ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 3
... their marriage gain weight in the early years after ... various health problems related to being overweight. That ... satisfaction and weight gain, according to psychologist Andrea L. ... Methodist University in Dallas. "On average, spouses who ...
... body, called "angiogenesis," is usually discussed in connection with healing ... the female reproductive tract, where the growth and breaking of ... But abnormal growth of blood vessels can have painful consequences ... research associate Dr. Dana Chuderland of Tel Aviv University,s Sackler ...
... US$11.5 billion worth of fish from beyond their country,s own ... according to a new study led by fisheries scientists at ... in the journal Fish and Fisheries , estimates that ... it reports to the United Nation,s Food and Agriculture Organization, ...
Cached Biology News:Marriage can threaten health: Study finds satisfied newlyweds more likely to gain weight 2New relief for gynecological disorders 2New relief for gynecological disorders 3Chinese foreign fisheries catch 12 times more than reported: UBC research 2
(Date:6/29/2015)... , June 29, 2015  MiMedx Group, Inc. ... utilizing human amniotic tissue and patent-protected processes to develop ... Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental ... Parker H. "Pete" Petit, has been awarded the Lifetime ... 2015 Southeast Program. The Entrepreneur Of ...
(Date:6/29/2015)... 2015   Veracyte, Inc . (Nasdaq: VCYT ... molecular cytology, today announced that it has been named ... list for the second year in a row. The ... an annual survey of Bay Area-company employees. ... to which Veracyte values our employees and their individual ...
(Date:6/26/2015)... KANSAS CITY, Kan. , June 26, ... (NASDAQ: PETX ), a pet therapeutics ... commercialization of innovative biopharmaceutical products for companion ... pivotal field effectiveness study of capromorelin (AT-002), ... in dogs.  Capromorelin is a small molecule ...
(Date:6/26/2015)... and MUMBAI, India , June 26, ... TCS) a leading global IT services, consulting and business ... a Leader in Worldwide Life Sciences R&D Risk-Based Monitoring ... IDC MarketScape: Worldwide Life Science R&D Risk-Based Monitoring 2015 ... The report evaluated eight leading IT services vendors ...
Breaking Biology Technology:EY Entrepreneur Of The Year Program Recognizes Pete Petit, The Chairman & CEO of MiMedx 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 2Aratana Therapeutics Announces Positive Pivotal Results for AT-002 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 5TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4
... Industry Readiness and Questions Fiscal ... Delaying Biogenerics -, WASHINGTON, Sept. 6 Expensive ... patents,expire, and generic companies stand ready to add biogenerics ... legislation enabling the U.S.,Food and Drug Administration (FDA) to ...
... BSX ) today announced that the Company,s Board ... Mr. Elliott, 58, is Chairman of the Board of ... Chief Executive Officer of,Zimmer from 2001 to 2007 and ... and director experience in medical devices,orthopaedics and other industries. ...
... on September 13, 2007 at the 14th, International Symposium on Hepatitis ... ... in Glasgow, Scotland, VALLEY COTTAGE, New York, September 6 ... today,that a late breaker abstract, entitled "Potent Small Molecule HCV,Inhibitors Affecting ...
Cached Biology Technology:Biogenerics Will Save Billions, Says Hospira CEO 2Biogenerics Will Save Billions, Says Hospira CEO 3Biogenerics Will Save Billions, Says Hospira CEO 4Boston Scientific Announces Election of Ray Elliott to Its Board of Directors 2Boston Scientific Announces Election of Ray Elliott to Its Board of Directors 3XTL Biopharmaceuticals Announces Presentation of Novel Pre-Clinical Inhibitors of Hepatitis C at an Upcoming International Scientific Conference 2
... Amplification Kit, 100 reactions. Prepare circular ... 4-6 h.Generate microgram quantities of template ... material.Use amplified DNA directly for cycle ... or M13 liquid cultures, colonies, plaques, ...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
For quantitative determination of Aldolase in Serum (an indicator of muscle damage). Ready-to-use liquid stable reagent. Formulated to eliminate interference from pyruvates. Application sheets are ...
This Universal 24" X 18" (61 X 45.7cm.) shaker platforms will accept any Thermo Forma shaker flask clip....
Biology Products: