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Grapes may aid a bunch of heart risk factors, animal study finds
Date:10/28/2008

the diet (by weight) for rats that received grapes as part of either a low-salt or high-salt diet. The rats that received hydrazine were fed it through their water supply in a dose that has been previously shown to be effective in reducing blood pressure.

The rats in the high-salt grape and high-salt hydrazine groups did develop high blood pressure over time, but they had lower systolic blood pressures than the high-salt rats that did not receive grapes.

The researchers also measured the distortion of the heart size, weight and function that occurred over time characteristics of heart failure and found that the high-salt grape group had less of a change than the high-salt hydrazine group. Parameters related to the diastolic blood pressure an important factor in human heart failure and to the heart's relaxation during the diastolic phase also changed in just the high-salt grape group. Finally, the grape-fed rats had improved cardiac output, or more blood pumped per unit of time.

The researchers also looked for signs of inflammation, oxidative damage and other molecular indicators of cardiac stress. Again, the rats that received the high-salt grape diet had lower levels of these markers than rats that received the high-salt diet with hydrazine and even the low-salt grape-eating rats had lower levels than the rats that received a low-salt diet alone.

In all, the researchers say, the study demonstrates that a grape-enriched diet can have broad effects on the development of hypertension and the risk factors that go along with it. Whether the effect can be replicated in humans, they say, remains to be seen.


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Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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