Navigation Links
Grape consumption may offer benefits for symptomatic knee osteoarthritis
Date:5/9/2014

Fresno, CA New research presented last week at the Experimental Biology conference in San Diego, California, suggests that regular grape consumption may help alleviate pain associated with symptomatic osteoarthritis of the knee, and improve joint flexibility and overall mobility. Researchers attribute these potential benefits to the polyphenols found in grapes.

The sixteen week clinical study, undertaken by Texas Woman's University, was designed to investigate the benefits of grape consumption on inflammation and osteoarthritis outcomes. 72 men and women with knee osteoarthritis (OA) were assigned to either consume grapes in the form of a whole grape freeze-dried powder, or a placebo powder.

The study results, presented by lead investigator Shanil Juma, Ph.D., showed that both men and women consuming a grape-enriched diet had a significant decrease in self-reported pain related to activity and an overall decrease in total knee symptoms. This beneficial effect was more pronounced in females. Additionally, age-related differences were observed: there was a 70% increase in very hard activity for those under 64 years of age consuming the grape powder, while those receiving the placebo reported a significant decrease in very hard activity. Participants over 65 years, whether consuming grapes or the placebo, reported a decline in moderate to hard activities.

Evidence of increased cartilage metabolism was observed in men consuming the grape-enriched diet; they had higher levels of an important cartilage growth factor (IGF-1) than those on placebo. This protective effect was not observed in the females. The researchers noted that no difference in range of motion was observed for either the grape group or the placebo group. The serum marker for inflammation (IL1-β) measured was increased in both placebo and grape groups, although much less of an increase was observed in the grape group.

"These findings provide promising data that links grape consumption to two very important outcomes for those living with knee osteoarthritis: reduced pain and improvements in joint flexibility," said Dr. Juma. "More research is needed to better understand the results of the serum biomarkers, as well as the age and gender differences observed."

Dr. Juma also shared results from a recent cell study that looked at the effects of whole grape polyphenols on cartilage cell integrity and markers of cartilage health. Cartilage cells were first treated with various doses of whole grape polyphenols, and then stimulated with an inflammatory agent. Cell proliferation significantly increased in a dose dependent manner in the grape polyphenol treated cells in the presence of an inflammatory agent. Additionally a marker for cartilage degradation was significantly lower with the three highest doses of the whole grape polyphenols when compared to control cells and cells treated with the inflammatory agent, suggesting a possible protective effect of grapes on cartilage cells.

Osteoarthritis is a condition where the natural cushioning between joints the cartilage wears away. Millions of Americans are affected by osteoarthritis: according to the Arthritis Foundation, more than 27 million people have osteoarthritis and knees are an area most commonly affected. Osteoarthritis is more likely to occur in people over 45 years of age, and women are more likely to have osteoarthritis than men.


'/>"/>

Contact: Courtney Romano
courtneyromano@comcast.net
425-889-8817
California Table Grape Commission
Source:Eurekalert

Related biology news :

1. Grape skin extract may soon be answer to treating diabetes
2. New tool to unlock genetics of grape-growing
3. Geography has impact on grapevine moths success in French vineyards
4. Grape consumption associated with healthier eating patterns in US children and adults
5. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
6. Grape intake may protect against metabolic syndrome-related organ damage
7. Even in same vineyard, different microbes may create variations in wine grapes
8. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
9. A digital portrait for grapes indicates their ripeness
10. Compound in grapes, red wine could be key to fighting prostate cancer
11. Selective grazing and aversion to olive and grape leaves achieved in goats and sheep
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... , ... July 20, 2017 , ... ... Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering and Computer Science ... Award winner. Presented annually, the award recognizes an individual who has made ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... Dr. Asher ... the winning recipients of the 2017 IAC Awards at the 22nd World Congress on ... committee also named four faculty to receive the Distinguished Fellowship Awards. , Dr. Asher ...
(Date:7/20/2017)... ... 20, 2017 , ... VIC Technology Venture Development™ (VIC™), is pleased ... This addition continues to strengthen and diversify VIC’s board. , "We are excited ... is a highly accomplished business executive with a broad range of experience directly relevant ...
(Date:7/20/2017)... Minn., July 20, 2017   KCNQ2 Cure ... genetic evaluations company, today announced that they have ... a genetic mutation implicated in KCNQ2 epileptic encephalopathy. ... for a second case involving an additional KCNQ2 ... Cure Alliance and Pairnomix entered into a collaboration ...
Breaking Biology Technology: