Therapeutic Small Molecule Inhibitors to Treat Pulmonary Fibrosis
Investigator: David W.H. Riches, PhD
Dr. Riches has been awarded $91,000 to identify therapeutic molecules capable of blocking molecular pathways that could stop scar-formation in idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no effective treatment that kills approximately 45,000 American every year. Fibroblasts normally secrete collagen to help hold wounds together so that tissue repair can proceed. In IPF, however, fibroblasts in the lung continue producing collagen, which forms scar tissue, long after they should have died. Dr. Riches will search for molecules that will restore a cell suicide pathway. The identification of such molecules could pave the way for an innovative therapeutic approach to the treatment of IPF, and possibly colon and pancreatic cancers. Dr. Riches has a patent pending for his invention.
BCMA-Fc Chimeras as Therapeutics for Autoimmunity
Investigators: Gongyi Zhang, PhD, and John Cambier, PhD
Drs. Zhang and Cambier have been awarded $99,832 to develop proteins that could inactivate B cells involved in B-cell mediated diseases such as lymphoma, leukemia, rheumatoid arthritis, lupus and organ-transplant rejection. The researchers will build on Dr. Zhang's discovery of the crystal structure of the B cell stimulator BAFF bound to cell-surface receptors to rationally design a molecule to disrupt this binding. Dr. Zhang has been awarded two patents (#6,475,987 and #7,825,089) for related inventions.
Generation of Bispecific Antibodies for Targeting Autoimmune-Associated B Cells
Investigators: Philippa Marrack, PhD, and Anatoly Rubtsov, PhD
Drs. Marrack and Rubtsov have been awarded $77,810 to design antibodies that will target
|Contact: William Allstetter|
National Jewish Health