Navigation Links
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
Date:1/25/2013

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.2 million from the National Institute of General Medical Sciences of the National Institutes of Health to identify, test and develop a series of drug candidates for a number of diseases, including rheumatoid arthritis, heart disease and several neurodegenerative disorders.

Derek R. Duckett, associate scientific director in TSRI's Translational Research Institute, and Peter S. Hodder, senior director of lead identification at the Translational Research Institute, will act as co-principal investigators for the three-year grant.

The project will focus on an enzyme known as ASK1, which is part of a larger family of mitogen-activated protein kinases (MAP kinases) that help control how cells respond to stress and is involved in mediating cell survival and programmed cell death (apoptosis). Genetic target validation studies have demonstrated that loss of this kinase shows remarkable efficacy in animal models of various diseases.

"While ASK1 is a highly druggable target, no tool compounds are currently available to probe its biology," Duckett pointed out. "This award will help us remedy the situation."

The new grant will allow the Scripps Florida scientists to perform a high-throughput screening campaign of the TSRI compound collection at their state-of-the-art screening facility. "Our team approach will identify the best lead molecules that will help define the roles that ASK1 plays in normal physiological processes as well as in disease states," Duckett said. "Such leads will also serve as good starting material for chemistry optimization efforts for future therapeutics."

"A very exciting prospect of this research effort is that Scripps's drug discovery compound collection will be assayed for novel inhibitors of ASK1 activity," said Hodder. "Past screening efforts with this collection yielded the antecedents of clinically relevant compounds, and the research plan we have in place bodes well for a similar outcome from this effort."


'/>"/>
Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. USDA grant advancing deadly plant disease, insect research
2. Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust
3. Childrens Hospital of Philadelphia receives federal grant to improve health care decision-making
4. AgriLife Research gets grant to crack biofuel production waste issue
5. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
6. Italian immigrants live longer
7. Grant funded to improve mothers nutrition before pregnancy and impact on baby
8. Researchers and company from Luxembourg awarded a grant from Michael J. Fox Foundation
9. University of Illinois receives grant to study ozone resistance in corn
10. Grant furthers Mercyhurst research for human pathogens in Great Lakes
11. MSU uses grant to help students master scientific mumbo jumbo
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
(Date:6/22/2016)... Research and Markets has announced the addition ... their offering. The global ... billion in 2013. The market is expected to grow at a ... 2020, increasing from $50.6 billion in 2015 to $96.6 billion in ... forecast period (2015 to 2020) are discussed. As well, new products ...
Breaking Biology Technology: