Navigation Links
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
Date:1/25/2013

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.2 million from the National Institute of General Medical Sciences of the National Institutes of Health to identify, test and develop a series of drug candidates for a number of diseases, including rheumatoid arthritis, heart disease and several neurodegenerative disorders.

Derek R. Duckett, associate scientific director in TSRI's Translational Research Institute, and Peter S. Hodder, senior director of lead identification at the Translational Research Institute, will act as co-principal investigators for the three-year grant.

The project will focus on an enzyme known as ASK1, which is part of a larger family of mitogen-activated protein kinases (MAP kinases) that help control how cells respond to stress and is involved in mediating cell survival and programmed cell death (apoptosis). Genetic target validation studies have demonstrated that loss of this kinase shows remarkable efficacy in animal models of various diseases.

"While ASK1 is a highly druggable target, no tool compounds are currently available to probe its biology," Duckett pointed out. "This award will help us remedy the situation."

The new grant will allow the Scripps Florida scientists to perform a high-throughput screening campaign of the TSRI compound collection at their state-of-the-art screening facility. "Our team approach will identify the best lead molecules that will help define the roles that ASK1 plays in normal physiological processes as well as in disease states," Duckett said. "Such leads will also serve as good starting material for chemistry optimization efforts for future therapeutics."

"A very exciting prospect of this research effort is that Scripps's drug discovery compound collection will be assayed for novel inhibitors of ASK1 activity," said Hodder. "Past screening efforts with this collection yielded the antecedents o
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. USDA grant advancing deadly plant disease, insect research
2. Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust
3. Childrens Hospital of Philadelphia receives federal grant to improve health care decision-making
4. AgriLife Research gets grant to crack biofuel production waste issue
5. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
6. Italian immigrants live longer
7. Grant funded to improve mothers nutrition before pregnancy and impact on baby
8. Researchers and company from Luxembourg awarded a grant from Michael J. Fox Foundation
9. University of Illinois receives grant to study ozone resistance in corn
10. Grant furthers Mercyhurst research for human pathogens in Great Lakes
11. MSU uses grant to help students master scientific mumbo jumbo
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
(Date:8/20/2014)...  The second annual Biometrics UnPlugged Executive Summit, ... Florida on September 15, 2014, will ... and Strategy at Samsung, and Philippe de Raet, Vice ... this year,s event is Mobility at the Crossroads ... UnPlugged: Mobility at the Crossroads of Commerce & ...
(Date:8/19/2014)... 19, 2014 To improve students, chances of ... the University of Houston (UH) implemented a comprehensive ... at risk for failure. , Through a ... (THECB), the Department of Biology and Biochemistry embarked ... taking "General Biology" for non-majors and "Introductory Biology" ...
(Date:8/19/2014)... German . ... If a large amount of electricity is to be produced ... have to be stored during productive periods so that these ... far from adequate for the purpose. Science and industry are ... on battery systems that used to be too expensive or ...
Breaking Biology News(10 mins):Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3
... Boston, MA Using 120 years of feathers ... University researchers have been able to track increases in ... nigripes ), an endangered seabird that forages extensively throughout ... the observed increase in methylmercury levels, most likely from ...
... University of the Negev software engineering students have developed ... computer without using a keyboard or mouse only ... to develop devices to read brainwaves and operate specific ... a laboratory setting. The BGU ...
... April 18, 2011 Mention vitamin D-fortified foods and ... with the sunshine vitamin since the 1930s. A new ... Challenges/Chemistry Solutions" podcast series says that vitamin D-fortified bread ... essential nutrient that is difficult to get naturally in ...
Cached Biology News:Mercury on the rise in endangered Pacific seabirds 2
(Date:8/20/2014)... Francisco, CA (PRWEB) August 20, 2014 ... Conference is being held on October 29-30 in ... perspectives from industry, academic and government researchers and clinicians ... in the space. , In the twelve years ... one hundred therapies have been introduced with pharmacogenetic information ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... Research and Markets  has announced the addition of ... Report" report to their offering. This report ... US$ Thousands by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , ... Latin America . Annual estimates and forecasts are provided ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Robin Williams’ ... disease can take on an individual. Symptoms range ... facial expression, problems swallowing and severe depression. Parkinson’s ... dying off of dopamine producing neurons of the brain. ... a disease that slowly and progressively gets worse, they ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2EQ-5D™ Assessment Now Available for iPad 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3
... 22 Edwards Lifesciences,Corporation (NYSE: EW ... of heart valves,today announced the opening of ... North Crescent, Singapore. The state-of-the-art facility produces,Edwards, ... also serves as the headquarters for Edwards, ...
... 22 Celldex,Therapeutics (a wholly-owned subsidiary of AVANT,Immunotherapeutics)(Nasdaq: ... product,candidate, CDX-110, being developed for the treatment of ... oral presentation at the 44th,Annual Meeting of the ... will be held at McCormick Place in Chicago ...
... to Add Valuable Clinical Development Expertise, SAN ... company focused on the development of novel Toll-Like,Receptor ... respiratory and,autoimmune diseases, announced today the appointment of ... "We are pleased to have Elliott join our ...
Cached Biology Technology:Edwards Lifesciences Opens New Singapore Heart Valve Facility 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 3VentiRx Pharmaceuticals Appoints Dr. Elliott Grossbard to Board of Directors 2
WASF2 Immunogen: WASF2 (NP_008921, 73 a.a. ~ 173 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
...
Sheep polyclonal to Malate Dehydrogenase ( Abpromise for all tested applications). Antigen: Full length protein - Pig heart malate dehydrogenase. Entrez Gene ID: 4190 Swiss Protein ID: P...
Biology Products: