Navigation Links
Grand Challenge grant awarded to team led by Nationwide Children's researcher

The Saving Lives at Birth: A Grand Challenge for Development recently shortlisted 53 finalists from around the world from more than 400 entries. Only 22 teams were awarded grants for their bold, new ideas to save the lives of mothers and newborns in developing countries. The Research Institute at Nationwide Children's Hospital was one of the four institutions in the competition to be awarded transition-to-scale grants (up to $2 million for four years) for the development of a low-cost paper-based urine test for early diagnosis of preeclampsia to reduce preeclampsia-related morbidity and mortality in resource-limited areas.

This project is a multidisciplinary team effort led by Irina Buhimschi, MD, director of the Center for Perinatal Research at The Research Institute at Nationwide Children's and a professor of Pediatrics at The Ohio State University College of Medicine. "We developed a method of diagnosing and predicting preeclampsia that is innovative, low cost, sustainable and scalable," says Dr. Buhimschi. The paper-based urine test enables early diagnosis by revealing altered proteins through Congo Reda readily available dye used worldwide in textiles, wood pulp and paper.

Other collaborators include Dr. Catalin Buhimschi (chief of the division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center), Dr. Hemant Tagare and Dr. Michael Choma (Yale University School of Medicine), Dr. Robert Pattinson and Dr. Pedro Mulder (University of Pretoria, South Africa), Dr. Thomas Easterling (University of Washington, Seattle), Dr. Hillary Bracken and Dr. Beverly Winikoff (Gynuity Health Projects).

Proof-of- principle seed funding for the team's idea was provided by the Bill and Melinda Gates Foundation Grand Challenges Explorations (GCE).

In limited-resource settings, morbidity and mortality from preeclampsia results from a delayed or lack of diagnosis of preeclampsia, a hypertensive condition unique to human pregnancy. Drawing upon the team's basic science findings, the team developed the paper-based urine test for diagnosing and predicting preeclampsia, which has the potential to decrease maternal and fetal mortality worldwide.

The innovation is rooted in the team's scientific discovery that preeclampsia is similar to Alzheimer's disease at the molecular level, through derangements in protein structure. The team provided novel evidence that the urine of pre-eclamptic women is highly enriched in these altered proteins. Using the dye Congo red, a prototype dye for identifying Alzheimer plaques, the team could quantify the altered proteins in urine of pregnant women.

Other transition-to-scale award nominees were from Africare of Dakar, Senegal; the Epidemiological Research Center in Sexual and Reproductive Health in Guatemala City, Guatemala; and Massachusetts General Hospital in Boston. The nominees will now enter into final negotiations before awards are issued.


Contact: Gina Bericchia, Nationwide Children's media relations
Nationwide Children's Hospital

Related biology news :

1. Meeting the grand challenge of a sustainable water supply
2. The State of Spinal Cord Injury Grand Rounds
3. Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more
4. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
5. UConn receives Grand Challenges Explorations Grant for research in global health and development
6. Carnegie Institution for Science receives Grand Challenges Explorations grant
7. BRI receives Grand Challenges Explorations Grant
8. Developing policy on moving threatened species called a grand challenge for conservation
9. Lawson recieves Grand Challenges Explorations grant for groundbreaking research
10. NIH, ONC, and EPA award $100,000 to winner of health and technology challenge
11. Science academies issue G-Science statements to call world leaders attention to global challenges
Post Your Comments:
(Date:6/21/2016)... 2016 NuData Security announced today that Randy ... principal product architect and that Jon Cunningham ... development. Both will report directly to Christopher ... reflect NuData,s strategic growth in its product and ... demand and customer focus values. ...
(Date:6/9/2016)... innovation leader in attendance control systems is proud to announce the introduction of fingerprint ... sure the right employees are actually signing in, and to even control the opening ... ... ... Photo ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... Dollar project, for the , Supply and Delivery ... IT Infrastructure , to Decatur ... Identity Management Solutions. Numerous renowned international vendors participated in the ... was selected for the most compliant and innovative solution. The ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking ... Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity as ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
(Date:6/23/2016)... Windsor, Connecticut (PRWEB) , ... June 23, 2016 ... ... will introduce a new line of intelligent tools designed, tuned and optimized exclusively ... place September 12–17 in Chicago. The result of a collaboration among several companies ...
Breaking Biology Technology: