Navigation Links
Grand Challenge grant awarded to team led by Nationwide Children's researcher
Date:8/26/2013

The Saving Lives at Birth: A Grand Challenge for Development recently shortlisted 53 finalists from around the world from more than 400 entries. Only 22 teams were awarded grants for their bold, new ideas to save the lives of mothers and newborns in developing countries. The Research Institute at Nationwide Children's Hospital was one of the four institutions in the competition to be awarded transition-to-scale grants (up to $2 million for four years) for the development of a low-cost paper-based urine test for early diagnosis of preeclampsia to reduce preeclampsia-related morbidity and mortality in resource-limited areas.

This project is a multidisciplinary team effort led by Irina Buhimschi, MD, director of the Center for Perinatal Research at The Research Institute at Nationwide Children's and a professor of Pediatrics at The Ohio State University College of Medicine. "We developed a method of diagnosing and predicting preeclampsia that is innovative, low cost, sustainable and scalable," says Dr. Buhimschi. The paper-based urine test enables early diagnosis by revealing altered proteins through Congo Reda readily available dye used worldwide in textiles, wood pulp and paper.

Other collaborators include Dr. Catalin Buhimschi (chief of the division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center), Dr. Hemant Tagare and Dr. Michael Choma (Yale University School of Medicine), Dr. Robert Pattinson and Dr. Pedro Mulder (University of Pretoria, South Africa), Dr. Thomas Easterling (University of Washington, Seattle), Dr. Hillary Bracken and Dr. Beverly Winikoff (Gynuity Health Projects).

Proof-of- principle seed funding for the team's idea was provided by the Bill and Melinda Gates Foundation Grand Challenges Explorations (GCE).

In limited-resource settings, morbidity and mortality from preeclampsia results from a delayed or lack of diagnosis of preeclampsia, a hypertensive condition unique to human pregnancy. Drawing upon the team's basic science findings, the team developed the paper-based urine test for diagnosing and predicting preeclampsia, which has the potential to decrease maternal and fetal mortality worldwide.

The innovation is rooted in the team's scientific discovery that preeclampsia is similar to Alzheimer's disease at the molecular level, through derangements in protein structure. The team provided novel evidence that the urine of pre-eclamptic women is highly enriched in these altered proteins. Using the dye Congo red, a prototype dye for identifying Alzheimer plaques, the team could quantify the altered proteins in urine of pregnant women.

Other transition-to-scale award nominees were from Africare of Dakar, Senegal; the Epidemiological Research Center in Sexual and Reproductive Health in Guatemala City, Guatemala; and Massachusetts General Hospital in Boston. The nominees will now enter into final negotiations before awards are issued.


'/>"/>

Contact: Gina Bericchia, Nationwide Children's media relations
Gina.Bericchia@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related biology news :

1. Meeting the grand challenge of a sustainable water supply
2. The State of Spinal Cord Injury Grand Rounds
3. Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more
4. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
5. UConn receives Grand Challenges Explorations Grant for research in global health and development
6. Carnegie Institution for Science receives Grand Challenges Explorations grant
7. BRI receives Grand Challenges Explorations Grant
8. Developing policy on moving threatened species called a grand challenge for conservation
9. Lawson recieves Grand Challenges Explorations grant for groundbreaking research
10. NIH, ONC, and EPA award $100,000 to winner of health and technology challenge
11. Science academies issue G-Science statements to call world leaders attention to global challenges
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... findings on what they believe could be a new and helpful biomarker for ... research. Click here to read it now. , Biomarkers are components ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of 8.5 ... end machines that use the more unconventional z-dimension of 20mm. Z-dimension or ... the cuvette holder. , FireflySci has developed several Agilent flow cell product lines ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
Breaking Biology Technology: