Navigation Links
Grand Challenge grant awarded to team led by Nationwide Children's researcher
Date:8/26/2013

The Saving Lives at Birth: A Grand Challenge for Development recently shortlisted 53 finalists from around the world from more than 400 entries. Only 22 teams were awarded grants for their bold, new ideas to save the lives of mothers and newborns in developing countries. The Research Institute at Nationwide Children's Hospital was one of the four institutions in the competition to be awarded transition-to-scale grants (up to $2 million for four years) for the development of a low-cost paper-based urine test for early diagnosis of preeclampsia to reduce preeclampsia-related morbidity and mortality in resource-limited areas.

This project is a multidisciplinary team effort led by Irina Buhimschi, MD, director of the Center for Perinatal Research at The Research Institute at Nationwide Children's and a professor of Pediatrics at The Ohio State University College of Medicine. "We developed a method of diagnosing and predicting preeclampsia that is innovative, low cost, sustainable and scalable," says Dr. Buhimschi. The paper-based urine test enables early diagnosis by revealing altered proteins through Congo Reda readily available dye used worldwide in textiles, wood pulp and paper.

Other collaborators include Dr. Catalin Buhimschi (chief of the division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center), Dr. Hemant Tagare and Dr. Michael Choma (Yale University School of Medicine), Dr. Robert Pattinson and Dr. Pedro Mulder (University of Pretoria, South Africa), Dr. Thomas Easterling (University of Washington, Seattle), Dr. Hillary Bracken and Dr. Beverly Winikoff (Gynuity Health Projects).

Proof-of- principle seed funding for the team's idea was provided by the Bill and Melinda Gates Foundation Grand Challenges Explorations (GCE).

In limited-resource settings, morbidity and mortality from preeclampsia results from a delayed or lack of diagnosis of preeclampsia, a hypertensive condition unique to human pregnancy. Drawing upon the team's basic science findings, the team developed the paper-based urine test for diagnosing and predicting preeclampsia, which has the potential to decrease maternal and fetal mortality worldwide.

The innovation is rooted in the team's scientific discovery that preeclampsia is similar to Alzheimer's disease at the molecular level, through derangements in protein structure. The team provided novel evidence that the urine of pre-eclamptic women is highly enriched in these altered proteins. Using the dye Congo red, a prototype dye for identifying Alzheimer plaques, the team could quantify the altered proteins in urine of pregnant women.

Other transition-to-scale award nominees were from Africare of Dakar, Senegal; the Epidemiological Research Center in Sexual and Reproductive Health in Guatemala City, Guatemala; and Massachusetts General Hospital in Boston. The nominees will now enter into final negotiations before awards are issued.


'/>"/>

Contact: Gina Bericchia, Nationwide Children's media relations
Gina.Bericchia@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related biology news :

1. Meeting the grand challenge of a sustainable water supply
2. The State of Spinal Cord Injury Grand Rounds
3. Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more
4. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
5. UConn receives Grand Challenges Explorations Grant for research in global health and development
6. Carnegie Institution for Science receives Grand Challenges Explorations grant
7. BRI receives Grand Challenges Explorations Grant
8. Developing policy on moving threatened species called a grand challenge for conservation
9. Lawson recieves Grand Challenges Explorations grant for groundbreaking research
10. NIH, ONC, and EPA award $100,000 to winner of health and technology challenge
11. Science academies issue G-Science statements to call world leaders attention to global challenges
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita ... miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject of ... now. , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
Breaking Biology Technology: