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Grafted limb cells acquire molecular 'fingerprint' of new location, UCI study shows
Date:10/24/2013

n her study, McCusker found that signals from nerve fibers played a crucial role in sustaining the cells' ability to change their identity to suit a new environment throughout the course of regeneration. She hypothesizes that it's important for the nerve fibers to maintain positional plasticity in the blastema until a complete blueprint of the new limb is formulated.

These findings also have potential implications in cancer biology, as cancer cells too are strongly influenced by the surrounding tissue environment.

"Our study shows that the blueprint, which drives the behavior of cells, can be manipulated," McCusker noted. "Thus, understanding how differing environments affect blastema cell behavior will provide valuable insight into how to control the behavior of cancer cells."


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Contact: Andrea Burgess
andrea.burgess@uci.edu
949-824-6282
University of California - Irvine
Source:Eurekalert

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