Navigation Links
'Good' prion-like proteins boost immune response, UT Southwestern scientists report
Date:8/8/2011

DALLAS Aug. 8, 2011 A person's ability to battle viruses at the cellular level remarkably resembles the way deadly infectious agents called prions misfold and cluster native proteins to cause disease, UT Southwestern Medical Center researchers report.

This study marks the first discovery of so-called "good" prion-like proteins in human cells and the first to find such proteins involved in innate immunity: the way the body recognizes and responds to threats from viruses or other external agents, said Dr. Zhijian "James" Chen, professor of molecular biology and senior author of the study in the Aug. 5 print edition of the journal Cell.

"An understanding of how cells maintain good prion-like proteins called MAVS [mitochondrial antiviral signaling] protein may help us understand how some prions turn bad," said Dr. Chen, a Howard Hughes Medical Institute investigator at UT Southwestern. Moreover, the research may also deepen our knowledge of innate immunity and host defense, he said.

Prions are misfolded, self-perpetuating proteins responsible for fatal brain infections such as bovine spongiform encephalopathy so-called mad cow disease in cattle and the extremely rare variant Creutzfeldt-Jakob Disease (vCJD) in some people who eat beef from infected cattle. Currently all prion-related diseases are untreatable and are fatal.

The MAVS prion-like proteins usually are scattered on the membranes of the energy-producing organelles called the mitochondria that reside inside cells throughout the body, he explained.

UT Southwestern researchers, investigating the cellular response to invasion by a member of the family of viruses that includes influenza and hepatitis, discovered that the MAVS proteins change shape and recruit other MAVS proteins to misfold and aggregate [cluster] in tough clumps on the surface of the mitochondrial membranes to defend against viral assault, Dr. Chen said.

The researchers create
'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Your mother was right: Study shows good posture makes you tougher
2. The truth about cats and dogs: Pets are good for mental health of everyday people
3. Can gulls smell out a good partner?
4. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
5. Betting on good luck and 4-leaf clovers
6. Eating dirt can be good for the belly, researchers find
7. Good guy or bad guy? Diagnosing stomach disease in pet reptiles
8. Clubbers can smell a good nightspot
9. As good as gold
10. Scorpion venom -- bad for bugs, good for pesticides
11. Study finds routine periodic fasting is good for your health, and your heart
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Good' prion-like proteins boost immune response, UT Southwestern scientists report
(Date:8/21/2014)... significant reduction in smog-producing toxins in past decade, ... new study shows that while the Greater Toronto ... toxins that contribute to smog, the city continues ... pollution., Smog, which can cause or aggravate health ... is produced by a set of complex photochemical ...
(Date:8/21/2014)... dandruff, eczema and other itchy, flaky maladies in humans ... Hawaiian coral reefs and the extreme environments of arctic ... the scientific journal PLOS Pathogens considers the ... genus Malassezia in light of new insights ... world. , University of Hawai,i at Mānoa scientist Anthony ...
(Date:8/21/2014)... AWI geologist Juliane Mller the Fram Strait is a key ... of this passage between Greenland and Svalbard warm Atlantic water ... the west side cold Arctic water masses and sea ice ... Atlantic. A considerable portion of the Atlantic water cools here ... layers. The circulation of the water caused in this manner ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3
... Fifty-nine leading life scientists from Europe and around the ... Organization (EMBO) for their proven excellence in research. Fifty-one ... Europe and neighbouring countries, while eight equally respected scientists ... as Associate Members, bringing the current membership total to ...
... herbicide that is effective at killing broadleaf weeds in ... Illinois and other Midwestern states, may finally have a ... developed a new grape called Improved Chancellor which is ... 1946, 2,4-Dichlorophenoxyacetic or 2, 4-D was introduced. It was ...
... is available in Spanish . An ... the Institute for Research in Biomedicine (IRB Barcelona) and ... (ICIQ, Tarragona), have discovered a substance with the capacity ... certain mutations that promote the appearance of cancer. Giralt, ...
Cached Biology News:EMBO honors 59 leading life scientists 2Herbicide-resistant grape could revitalize Midwest wine industry 2Herbicide-resistant grape could revitalize Midwest wine industry 3Design of a compound that stabilizes the main natural suppressor of tumors 2
(Date:8/22/2014)... The AMA is pleased to share with ... that Alaska Governor Sean Parnell has signed House Bill ... use of Unmanned Aircraft Systems and the continuation of ... that it is, “An Act relating to unmanned aircraft ... aircraft system.” It defines State of Alaska laws regarding ...
(Date:8/21/2014)... 2014 DNA vaccine pioneer Immunomic ... development of JRC-LAMP-vax, an innovative and safe potential treatment ... studies began this month in Hawaii, moving the world ... The Japanese red cedar releases pollen that causes devastating ... Cedar pollen wreaks similar havoc in Colorado, New Mexico ...
(Date:8/21/2014)... August 21, 2014 His Majesty Willem-Alexander, ... , The Court of His Majesty Willem-Alexander, King of ... the Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY ... 3. , The King will take part in the ... scheduled for 11 a.m.-12:20 p.m. and tour the plant. ...
(Date:8/21/2014)... 21, 2014 OTC Markets Group ... a biotechnology company, on its approval to list ... on OTCQX®, the best marketplace for established U.S. ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... execution of its growth strategy and achievement of ...
Breaking Biology Technology:State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... March 10 Campbell Alliance, the leading ... industry, today announced that Ashwin Dandekar, Vice President, Brand ... Summit USA on March 30 and 31, 2009 at ... Dr. Dandekar will also present a workshop at EyeForPharma,s ...
... Off-Label Use of Avastin Will Take Market Share ... to a New Report from Decision ResourcesWALTHAM, Mass., ... world,s leading research and advisory firms for pharmaceutical ... percent growth in the age-related macular degeneration (AMD) ...
... NxStage Medical, Inc. (Nasdaq: NXTM ), a ... Jeffrey H. Burbank, Chief Executive Officer, will be presenting ... on Monday, March 16, 2009 at the Marriot Copley ... for Monday, March 16th at 4:40 p.m. ET. ...
Cached Biology Technology:Campbell Alliance Brand Management Practice to Present at EyeForPharma's Oncology Summit USA and Oncology Market Access Europe Conference 2Campbell Alliance Brand Management Practice to Present at EyeForPharma's Oncology Summit USA and Oncology Market Access Europe Conference 3Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe 2Robust Annual Growth Through 2012 in the Age-Related Macular Degeneration Market Will Be Driven by Expanding Use of Lucentis in Europe 3NxStage to Present at the Cowen and Company 29th Annual Healthcare Conference 2
Anti-human C3a/C3a des-Arg (neo-epitope), Clone 2991, Monoclonal Antibody...
Phospho-FADD (Ser194) Antibody (Human Specific)...
... polyclonal to FANCM ( Abpromise for ... Synthetic peptide derived from within residues ... (Note: the amino acid sequence is ... ab27787 .) Entrez ...
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Biology Products: