Navigation Links
Good news for nanomedicine: Quantum dots appear safe in pioneering study on primates
Date:5/20/2012

BUFFALO, N.Y. -- A pioneering study to gauge the toxicity of quantum dots in primates has found the tiny crystals to be safe over a one-year period, a hopeful outcome for doctors and scientists seeking new ways to battle diseases like cancer through nanomedicine.

The research, which will appear on May 20 in Nature Nanotechnology online, is likely the first to test the safety of quantum dots in primates. The study and information in this press release are embargoed until Sunday, May 20, 2012 at 1 p.m. U.S. Eastern Standard Time.

In the study, scientists found that four rhesus monkeys injected with cadmium-selenide quantum dots remained in normal health over 90 days. Blood and biochemical markers stayed in typical ranges, and major organs developed no abnormalities. The animals didn't lose weight.

Two monkeys observed for an additional year also showed no signs of illness.

Quantum dots are tiny luminescent crystals that glow brightly in different colors. Medical researchers are eyeing the crystals for use in image-guided surgery, light-activated therapies and sensitive diagnostic tests. Cadmium selenide quantum dots are among the most studied, with potential applications not only in medicine, but as components of solar cells, quantum computers, light-emitting diodes and more.

The new toxicity study -- completed by the University at Buffalo, the Chinese PLA General Hospital, China's ChangChun University of Science and Technology, and Singapore's Nanyang Technological University -- begins to address the concern of health professionals who worry that quantum dots may be dangerous to humans.

The authors caution, however, that more research is needed to determine the nanocrystals' long-term effects in primates; most of the potentially toxic cadmium from the quantum dots stayed in the liver, spleen and kidneys of the animals studied over the 90-day period.

"This is the first study that uses primates as animal models for in vivo studies with quantum dots," said paper coauthor Paras Prasad, UB professor of chemistry and medicine, and executive director of UB's Institute for Lasers, Photonics and Biophotonics (ILPB). "So far, such toxicity studies have focused only on mice and rats, but humans are very different from mice. More studies using animal models that are closer to humans are necessary."

The cadmium build-up, in particular, is a serious concern that warrants further investigation, said Ken-Tye Yong, a Nanyang Technological University assistant professor who began working with Prasad on the study as a postdoctoral researcher at UB.

Because of that concern, the best in-vivo applications for cadmium-selenide quantum dots in medicine may be the ones that use the crystals in a limited capacity, said Mark Swihart, a third coauthor and a UB professor of chemical and biological engineering. Image-guided surgery, which could involve a single dose of quantum dots to identify a tumor or other target area, falls into this category.


'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert

Related biology news :

1. Nanomedicine: Ending hit and miss design
2. Strained quantum dots show new optical properties
3. New technique is quantum leap forward in understanding proteins
4. Rice eyes risks of quantum dots
5. Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
6. Diamonds may be the ultimate MRI probe, say Quantum physicists
7. Scientists find quantum mechanics at work in photosynthesis
8. Digging deep into diamonds, applied physicists advance quantum science and technology
9. Untangling the quantum entanglement behind photosynthesis
10. Zeroing in on quantum effects
11. Multicolor quantum dots aid in cancer biopsy diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... Canada , February 1, 2016 ... technological advancements to drive global touchfree intuitive gesture control ... --> Rising sales of consumer electronics coupled ... gesture control market size through ... consumer electronics coupled with new technological advancements to drive ...
(Date:2/1/2016)... 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces the launch ... Joey Fatone . Las Vegas , where Joey ... --> Las Vegas , where Joey appeared at the ... new video ad was filmed at the Consumer Electronics Show (CES2016) in ... booth to meet and greet fans. --> ...
(Date:1/27/2016)... CHESTER, Ohio , Jan. 27, 2016  Rite ... supplier based in West Chester, Ohio ... their award winning service staff, based in ... technical capacity and ability to provide modifications, installations and ... John Dovalina , CEO of PLUS, commented, "PLUS has ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... 08, 2016 , ... Net-Translators, an industry-leading provider of translation, ... revamped and improved website. In an on-going effort to further educate customers and ... communicate how the company designs and delivers thorough, high-quality results for its growing ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... for Public Policy for the National Organization for Rare Disorders (NORD). Dorman will ... ensure their voices are heard throughout the drug regulatory review process. , “Adding ...
(Date:2/9/2016)... BERG, a biopharmaceutical company uncovering health ... announced the appointment of Jason Haddock ... Haddock brings to BERG over 20 years of ... senior financial functions at pharmaceutical companies, as well ... Niven R. Narain , BERG,s ...
(Date:2/8/2016)... , February 8, 2016 ... Private Limited, an innovation-driven oncology company developing next ... less toxic, today announced that chairman emeritus of ... invested in the company as part of the ... joining existing investors Navam Capital and Aarin Capital. ...
Breaking Biology Technology: